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    METHODS, COMPOSITIONS, KITS, AND USES FOR ANALYSIS OF NUCLEIC ACIDS COMPRISING REPEATING A/T-RICH SEGMENTS
    1.
    发明申请
    METHODS, COMPOSITIONS, KITS, AND USES FOR ANALYSIS OF NUCLEIC ACIDS COMPRISING REPEATING A/T-RICH SEGMENTS 有权

    公开(公告)号：US20220136044A1

    公开(公告)日：2022-05-05

    申请号：US17456204

    申请日：2021-11-23

    申请人： Asuragen, Inc.

    发明人： Gary J. Latham ,  Sachin Sah

    IPC分类号： C12Q1/6844

    摘要： Described herein are methods, compositions, kits, and uses thereof for analysis of nucleic acid segments comprising a repeating A/T-rich segment, wherein the repeating A/T-rich segment is: (i) a homopolymeric segment comprising at least 10 A residues, at least 10 T residues, or at least 10 U residues, wherein the at least 10 A, T, or U residues are consecutive or interrupted once by one to three other nucleotides; or (ii) a segment comprising (TnA)m, (ATn)m, (TAn)m, or (AnT)m, wherein n is 2 or greater and m is such that the length of the repeating A/T-rich segment is 10 or more residues.

    PCR METHODS FOR CHARACTERIZING THE 5' UNTRANSLATED REGION OF THE FMR1 AND FMR2 GENES
    3.
    发明申请
    PCR METHODS FOR CHARACTERIZING THE 5' UNTRANSLATED REGION OF THE FMR1 AND FMR2 GENES 审中-公开
    用于表征FMR1和FMR2基因的5'未翻译区的PCR方法

    公开(公告)号：US20140248625A1

    公开(公告)日：2014-09-04

    申请号：US14191128

    申请日：2014-02-26

    申请人： Asuragen, Inc.

    发明人： Gary J. LATHAM ,  Liangjing CHEN ,  Sachin SAH

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6876 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q2565/125 ,  C12Q2531/113 ,  C12Q2525/151

    摘要： This disclosure relates to methods of determining the presence and position of AGG or interruptor elements within a trinucleotide (for example, CGG) repeat region, and to methods of determining the number of repeats present in this region, by amplifying a set of products with a set of primers of which at least one comprises a portion of the CGG repeat region, and resolving the products to produce a representation of product size and abundance.

    摘要翻译： 本公开内容涉及确定三核苷酸（例如，CGG）重复区域内的AGG或干扰子元件的存在和位置的方法以及确定存在于该区域中的重复次数的方法，通过用 一组引物，其至少一个包含CGG重复区域的一部分，并且解析产物以产生产物尺寸和丰度的表示。