公开(公告)号：US08663987B2

公开(公告)日：2014-03-04

申请号：US12994761

申请日：2009-05-26

申请人： Avinoam Kadouri ,  Avihay Bar-Ilan ,  Eldad Melamed ,  Daniel Offen ,  Ofer Sadan ,  Merav Bahat-Stromza

发明人： Avinoam Kadouri ,  Avihay Bar-Ilan ,  Eldad Melamed ,  Daniel Offen ,  Ofer Sadan ,  Merav Bahat-Stromza

IPC分类号： C12N5/071 ,  C12N5/079

CPC分类号： A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

摘要： An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.