公开(公告)号：US11986384B2

公开(公告)日：2024-05-21

申请号：US16923782

申请日：2020-07-08

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61F2/00 ,  A61L27/14 ,  A61L27/18 ,  A61L27/24 ,  A61L27/26 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58 ,  D06N3/00 ,  A61L27/34 ,  A61L27/50 ,  D04B21/12

CPC分类号： A61F2/08 ,  A61F2/0063 ,  A61L27/14 ,  A61L27/18 ,  A61L27/24 ,  A61L27/26 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58 ,  D06N3/0043 ,  A61F2002/0068 ,  A61F2002/0081 ,  A61F2210/0004 ,  A61F2210/0057 ,  A61F2210/0061 ,  A61F2210/0076 ,  A61F2240/001 ,  A61L27/34 ,  A61L27/50 ,  A61L2430/10 ,  D04B21/12 ,  D10B2509/08 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T442/2484 ,  Y10T442/419

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US20220362004A1

公开(公告)日：2022-11-17

申请号：US17838694

申请日：2022-06-13

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61F2/00 ,  A61L27/48 ,  D06N3/00 ,  A61L27/14 ,  A61L27/26 ,  A61L27/58

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US11116622B2

公开(公告)日：2021-09-14

申请号：US16785512

申请日：2020-02-07

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61F2/00 ,  A61L27/14 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61L27/48 ,  D06N3/00 ,  A61L27/26 ,  A61L27/58 ,  A61L27/34 ,  A61L27/50 ,  D04B21/12

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US20200315773A1

公开(公告)日：2020-10-08

申请号：US16785524

申请日：2020-02-07

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61L27/48 ,  A61L27/56 ,  A61L27/52

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US20200306029A1

公开(公告)日：2020-10-01

申请号：US16730006

申请日：2019-12-30

申请人： BIOREZ, INC.

发明人： Kevin A. Rocco ,  Dale R. Peterson ,  Joseph W. Reilly

IPC分类号： A61F2/08 ,  A61L27/56 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61F2/00 ,  A61L27/14 ,  A61L27/58

摘要： Implantable medical devices and prosthesis for rapid regeneration and replacement of tissues, and methods of making and using the devices, are described. The medical devices include a complex three-dimensional braided scaffold with a polymer composition and structure tailored to desired degradation profiles and mechanical properties. The composite three-dimensional braided scaffolds are braided from yarn bundles of biodegradable and bioresorbable polymeric fibers and/or filaments. Monofilament fibers and/or multifilament fibers can be twisted/plied in different combinations to form multifilament yarns, composite multifilament yarns, or composite yarns. The medical devices are useful as both structural prosthetics taking on the function of the tissue as it regenerates and as in vivo scaffolds for cell attachment and ingrowth.

公开(公告)号：US20170273775A1

公开(公告)日：2017-09-28

申请号：US15470619

申请日：2017-03-27

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Dale R. Peterson ,  Joseph W. Reilly

IPC分类号： A61F2/08 ,  A61L27/58 ,  A61L27/14 ,  A61F2/00

CPC分类号： A61F2/08 ,  A61F2/0077 ,  A61F2250/0023 ,  A61F2250/003 ,  A61L27/14 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/64 ,  A61L2430/10 ,  C08L67/04

摘要： Implantable medical devices and prosthesis for rapid regeneration and replacement of tissues, and methods of making and using the devices, are described. The medical devices include a complex three-dimensional braided scaffold with a polymer composition and structure tailored to desired degradation profiles and mechanical properties. The composite three-dimensional braided scaffolds are braided from yarn bundles of biodegradable and bioresorbable polymeric fibers and/or filaments. Monofilament fibers and/or multifilament fibers can be twisted/plied in different combinations to form multifilament yarns, composite multifilament yarns, or composite yarns. The medical devices are useful as both structural prosthetics taking on the function of the tissue as it regenerates and as in vivo scaffolds for cell attachment and ingrowth.

公开(公告)号：US11701217B2

公开(公告)日：2023-07-18

申请号：US17838694

申请日：2022-06-13

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61F2/00 ,  A61L27/48 ,  D06N3/00 ,  A61L27/14 ,  A61L27/26 ,  A61L27/58 ,  A61L27/34 ,  A61L27/50 ,  D04B21/12

CPC分类号： A61F2/08 ,  A61F2/0063 ,  A61L27/14 ,  A61L27/18 ,  A61L27/24 ,  A61L27/26 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58 ,  D06N3/0043 ,  A61F2002/0068 ,  A61F2002/0081 ,  A61F2210/0004 ,  A61F2210/0057 ,  A61F2210/0061 ,  A61F2210/0076 ,  A61F2240/001 ,  A61L27/34 ,  A61L27/50 ,  A61L2430/10 ,  D04B21/12 ,  D10B2509/08 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T442/2484 ,  Y10T442/419

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US11672646B2

公开(公告)日：2023-06-13

申请号：US17473571

申请日：2021-09-13

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61F2/00 ,  A61L27/14 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61L27/48 ,  D06N3/00 ,  A61L27/26 ,  A61L27/58 ,  A61L27/34 ,  A61L27/50 ,  D04B21/12

CPC分类号： A61F2/08 ,  A61F2/0063 ,  A61L27/14 ,  A61L27/18 ,  A61L27/24 ,  A61L27/26 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58 ,  D06N3/0043 ,  A61F2002/0068 ,  A61F2002/0081 ,  A61F2210/0004 ,  A61F2210/0057 ,  A61F2210/0061 ,  A61F2210/0076 ,  A61F2240/001 ,  A61L27/34 ,  A61L27/50 ,  A61L2430/10 ,  D04B21/12 ,  D10B2509/08 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T442/2484 ,  Y10T442/419

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US11357613B2

公开(公告)日：2022-06-14

申请号：US17379093

申请日：2021-07-19

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61F2/00 ,  A61L27/48 ,  D06N3/00 ,  A61L27/14 ,  A61L27/26 ,  A61L27/58 ,  A61L27/34 ,  A61L27/50 ,  D04B21/12

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US20210361407A1

公开(公告)日：2021-11-25

申请号：US17372999

申请日：2021-07-12

申请人： Biorez, Inc.

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61F2/00 ,  A61L27/48 ,  D06N3/00 ,  A61L27/14 ,  A61L27/26 ,  A61L27/58

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.