REGULATING PROTEIN SPONTANEOUS RUPTURES
    2.
    发明申请

    公开(公告)号:US20200216824A1

    公开(公告)日:2020-07-09

    申请号:US16731648

    申请日:2019-12-31

    Inventor: H. Peter Lu

    Abstract: Protein rupture under compressive forces can be regulated by cations. More specifically, pico-Newton forces can cause rupture of protein molecules, as shown in examples with calmodulin (CaM) and tau proteins, among others. However, rupture does not occur in the presence of various concentrations of cation(s), thus elucidating new targets for disease therapy and providing therapies for neurodegenerative diseases or other conditions involving protein misfolding, dysfunction, or aggregation.

    Materials and methods using Fe3+ coordination to carboxylates

    公开(公告)号:US10517997B1

    公开(公告)日:2019-12-31

    申请号:US15212233

    申请日:2016-07-16

    Abstract: Uronate-containing polysaccharide hydrogels that can be photo-patterned are described. The method involves forming a hydrogel and imetal-coordinating it with a reducible metallic cation and exposing the hydrogel to light in a desired pattern. The exposure to light reduces the metallic cation and results in an irreversible change in the elastic moduli and pore size of the irradiated portions of the patterned hydrogel. The method aha the benefit of allowing the user to produce such a hydrogel in any pattern desired. Patterned hydrogels and cell substrates formed by this method are also described.

    Cancer stem cell survivor lines
    5.
    发明授权
    Cancer stem cell survivor lines 有权
    癌症干细胞幸存者系

    公开(公告)号:US09080154B1

    公开(公告)日:2015-07-14

    申请号:US13855694

    申请日:2013-04-02

    CPC classification number: C12N5/0693 C12N5/0695

    Abstract: A method of determining the relative effectiveness of potential chemotherapeutic agents designed to inhibit neoplasm, growth or metastasis is described. The chemotherapeutic agent may be curcumin. The invention also relates to kits designed to aid in determining the relative effectiveness of potential chemotherapeutic agents. The invention also relates to cancer stem cell survivor lines that can be included in the kits and used in the method.

    Abstract translation: 描述了确定设计用于抑制肿瘤,生长或转移的潜在化学治疗剂的相对有效性的方法。 化疗剂可以是姜黄素。 本发明还涉及旨在帮助确定潜在化学治疗剂的相对有效性的试剂盒。 本发明还涉及可以包含在试剂盒中并用于该方法的癌症干细胞幸存者系。

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