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    Vaccines against HPV and HPV-related diseases
    7.
    发明授权
    Vaccines against HPV and HPV-related diseases 有权

    公开(公告)号：US10286058B2

    公开(公告)日：2019-05-14

    申请号：US15111357

    申请日：2015-01-13

    申请人： BAYLOR RESEARCH INSTITUTE

    发明人： SangKon Oh ,  Sandra Zurawski ,  Gerard Zurawski

    IPC分类号： A61K39/12 ,  A61K39/395 ,  C07K14/025 ,  C07K16/28 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

    摘要： Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV 16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.

    ENHANCEMENT OF PATHOGEN-SPECIFIC MEMORY TH17 CELL RESPONSES
    9.
    发明申请
    ENHANCEMENT OF PATHOGEN-SPECIFIC MEMORY TH17 CELL RESPONSES 审中-公开
    病毒特异性记忆TH17细胞应答的增强

    公开(公告)号：US20150064205A1

    公开(公告)日：2015-03-05

    申请号：US14484599

    申请日：2014-09-12

    申请人： BAYLOR RESEARCH INSTITUTE

    发明人： SangKon Oh ,  Jacques F. Banchereau ,  Gerard Zurawski ,  Hideki Ueno ,  Ling Ni

    IPC分类号： C07K16/28 ,  A61K47/42 ,  A61K47/36

    CPC分类号： C07K16/2851 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K39/39 ,  A61K47/36 ,  A61K47/42 ,  A61K2039/55572 ,  A61K2039/6056 ,  C07K2317/76 ,  C07K2319/035 ,  C12N2760/16134

    摘要： Compositions and methods for enhancing Th1/Th17 cell responses and decreasing Th2 cell responses are disclosed herein. In various embodiments the present invention describes activation of human dendritic cells and enhancement of antigen-specific T cell responses in a Dectin-1-expressing human dendritic cells comprising an anti-Dectin-1-specific antibody or fragment thereof fused with one or more antigens. TLR2 ligands may also be included to enhance the activation and for enhancement of T-cell responses. Further, the invention also includes methods based on the compositions described herein for the treatment of pathogenic infections.

    摘要翻译： 本文公开了用于增强Th1 / Th17细胞应答和降低Th2细胞应答的组合物和方法。 在各种实施方案中，本发明描述了在含有Dectin-1的人树状细胞中激活人树突状细胞的活化和增强抗原特异性T细胞应答，所述树突细胞包含与一种或多种抗原融合的抗Dectin-1特异性抗体或其片段 。 还可以包括TLR2配体以增强T细胞反应的活化和增强。 此外，本发明还包括基于本文所述的用于治疗病原体感染的组合物的方法。