公开(公告)号：US07351735B2

公开(公告)日：2008-04-01

申请号：US10501689

申请日：2003-02-21

Applicant: Chengzhi Zhang ,  Michael Burke ,  Zhi Chen ,  Jacques Dumas ,  Dongping Fan ,  Jianmei Fan ,  Holia Hatoum-Mokdad ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips

Inventor： Chengzhi Zhang ,  Michael Burke ,  Zhi Chen ,  Jacques Dumas ,  Dongping Fan ,  Jianmei Fan ,  Holia Hatoum-Mokdad ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips

IPC: A61K31/343 ,  A61K31/381 ,  C07D307/80 ,  C07D333/56

CPC classification number: C07D307/82 ,  C07D307/92 ,  C07D307/93 ,  C07D333/66 ,  C07D333/74 ,  C07D333/78 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D407/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D493/04

Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders

Abstract translation: 本发明涉及一般表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途

公开(公告)号：US07144885B2

公开(公告)日：2006-12-05

申请号：US10501690

申请日：2003-02-21

Applicant: Chengzhi Zhang ,  Michael Burke ,  Zhi Chen ,  Jacques Dumas ,  Dongping Fan ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips ,  Scott M. Wilhelm ,  Qian Zhao

Inventor： Chengzhi Zhang ,  Michael Burke ,  Zhi Chen ,  Jacques Dumas ,  Dongping Fan ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips ,  Scott M. Wilhelm ,  Qian Zhao

IPC: A61K31/497 ,  A61K31/4355 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/427

CPC classification number: C07D407/06 ,  C07D307/92 ,  C07D307/93 ,  C07D333/74 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D491/04 ,  C07D493/04

Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders

Abstract translation: 本发明涉及式（Ia，Ib）的新型稠合三环杂环及其用于治疗高增殖性疾病的用途

公开(公告)号：US07585888B2

公开(公告)日：2009-09-08

申请号：US12059984

申请日：2008-03-31

Applicant: Chengzhi Zhang ,  Michael J. Burke ,  Zhi Chen ,  Jacques P. Dumas ,  Dongping Fan ,  Jianmei Fan ,  Holia Hatoum-Mokdad ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips

Inventor： Chengzhi Zhang ,  Michael J. Burke ,  Zhi Chen ,  Jacques P. Dumas ,  Dongping Fan ,  Jianmei Fan ,  Holia Hatoum-Mokdad ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips

IPC: A61K31/343 ,  A61K31/381

CPC classification number: C07D307/82 ,  C07D307/92 ,  C07D307/93 ,  C07D333/66 ,  C07D333/74 ,  C07D333/78 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D407/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D493/04

Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.

Abstract translation: 本发明涉及通式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。

公开(公告)号：US08338595B2

公开(公告)日：2012-12-25

申请号：US12506033

申请日：2009-07-20

Applicant: Julie A. Dixon ,  Catherine Brennan ,  Karl Miranda ,  Brent Chandler ,  Barton Phillips ,  Jianmei Fan ,  Michael Brands ,  Andrea McClure ,  Benjamin D. Jones ,  Wenlang Fu ,  Donald Bierer ,  Steven Magnuson ,  Harold C. E. Kluender

Inventor： Julie A. Dixon ,  Catherine Brennan ,  Karl Miranda ,  Brent Chandler ,  Barton Phillips ,  Jianmei Fan ,  Michael Brands ,  Andrea McClure ,  Benjamin D. Jones ,  Wenlang Fu ,  Donald Bierer ,  Steven Magnuson ,  Harold C. E. Kluender

IPC: C07D487/04 ,  C07D417/02 ,  C07D413/02 ,  A61K31/53 ,  A61P35/00

CPC classification number: C07D491/113 ,  C07D487/04

Abstract: This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.

Abstract translation: 本发明涉及吡咯并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性病症和疾病的用途。

公开(公告)号：US20080293696A1

公开(公告)日：2008-11-27

申请号：US11630850

申请日：2005-06-23

Applicant: Catherine Brennan ,  Julie A. Dixon ,  William J. Scott ,  Aniko Redman ,  Benjamin D. Jones ,  Barton Phillips ,  Philip Wickens ,  Istvan Enyedy ,  Ellalahewage Kumarasinghe ,  Charles Kreiman ,  Jacques Dumas ,  Uday Khire ,  Chih-Yuan Chuang ,  Harold C.E. Kluender ,  Zhenqiu Hong ,  Lei Wang ,  Donald Bierer

Inventor： Catherine Brennan ,  Julie A. Dixon ,  William J. Scott ,  Aniko Redman ,  Benjamin D. Jones ,  Barton Phillips ,  Philip Wickens ,  Istvan Enyedy ,  Ellalahewage Kumarasinghe ,  Charles Kreiman ,  Jacques Dumas ,  Uday Khire ,  Chih-Yuan Chuang ,  Harold C.E. Kluender ,  Zhenqiu Hong ,  Lei Wang ,  Donald Bierer

IPC: A61K31/55 ,  C07D405/12 ,  A61K31/4433 ,  A61K31/444 ,  A61P35/00 ,  C07D405/14 ,  A61K31/506

CPC classification number: C07D319/08

Abstract: A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.

Abstract translation: 具有式（1）的化合物，其中含有E的环是苯基，吡啶或嘧啶。 在式（1）中，符号A表示其中基团R 4表示卤素，CF 3或H，条件是任何A上的CF 3基团的最大数目为2，并且A组中的最大氢数为2， 与它们连接的碳原子一起形成6元环，并且对于与连接的碳原子一起形成5元环的A基团，A上的最大氢数为1。 当E形成苯环时，Z表示N或CH，当E形成吡啶或嘧啶时，Z表示CH。 基团R1，R2和R3以及下标a，b和d如本文和权利要求中所定义。 还公开并要求保护含有式（1）化合物的药物组合物和使用式（1）化合物治疗癌症的方法。

公开(公告)号：US07384947B2

公开(公告)日：2008-06-10

申请号：US11512032

申请日：2006-08-28

Applicant: Chengzhi Zhang ,  Michael Burke ,  Zhi Chen ,  Jacques Dumas ,  Dongping Fan ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips ,  Scott M. Wilhelm ,  Qian Zhao

Inventor： Chengzhi Zhang ,  Michael Burke ,  Zhi Chen ,  Jacques Dumas ,  Dongping Fan ,  Benjamin D. Jones ,  Gaetan Ladouceur ,  Wendy Lee ,  Barton Phillips ,  Scott M. Wilhelm ,  Qian Zhao

IPC: A61K31/497 ,  A61K31/4355 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/427

CPC classification number: C07D407/06 ,  C07D307/92 ,  C07D307/93 ,  C07D333/74 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D491/04 ,  C07D493/04

Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.

Abstract translation: 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。