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1.发明授权Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号：US07585888B2
公开(公告)日：2009-09-08
申请号：US12059984
申请日：2008-03-31
申请人： Chengzhi Zhang , Michael J. Burke , Zhi Chen , Jacques P. Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人： Chengzhi Zhang , Michael J. Burke , Zhi Chen , Jacques P. Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号： A61K31/343 , A61K31/381
CPC分类号： C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要： This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译： 本发明涉及通式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
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2.发明授权Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号：US07351735B2
公开(公告)日：2008-04-01
申请号：US10501689
申请日：2003-02-21
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号： A61K31/343 , A61K31/381 , C07D307/80 , C07D333/56
CPC分类号： C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要： This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
摘要翻译： 本发明涉及一般表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途
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3.发明申请Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders 失效苯并呋喃和苯并噻吩衍生物可用于高增殖性疾病的治疗公开(公告)号：US20050139814A1
公开(公告)日：2005-06-30
申请号：US10501689
申请日：2003-02-21
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
IPC分类号： A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/443 , A61K31/4436 , A61K31/455 , A61K31/497 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P35/04 , B66F3/36 , C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D491/048 , C07D493/04
CPC分类号： C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要： This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译： 本发明涉及通用表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
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4.发明申请2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 审中-公开用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US20050215594A1
公开(公告)日：2005-09-29
申请号：US11117759
申请日：2005-04-28
申请人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
发明人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D45/02
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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5.发明申请公开(公告)号：US20060063760A1
公开(公告)日：2006-03-23
申请号：US10554390
申请日：2004-04-16
申请人： Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
发明人： Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
IPC分类号： A61K31/54 , A61K31/537 , A61K31/445 , A61K31/495 , A61K31/4172
CPC分类号： C07C259/06 , C07C311/08 , C07C311/29 , C07C317/32 , C07C2602/08 , C07D209/14 , C07D209/16 , C07D209/26 , C07D213/38 , C07D213/53 , C07D215/12 , C07D265/30 , C07D307/52 , C07D307/81 , C07D333/58 , C07D403/12 , C07D413/12
摘要： This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译： 本发明涉及式（I）化合物及其在治疗高增殖性疾病中的用途。
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公开(公告)号：US20120129893A1
公开(公告)日：2012-05-24
申请号：US13349199
申请日：2012-01-12
申请人： Jacques DUMAS , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人： Jacques DUMAS , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号： A61K31/4439 , C07D401/12 , C07D417/12 , A61P35/02 , A61K31/428 , A61K31/427 , A61P35/00 , C07D231/40 , A61K31/415
CPC分类号： C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号：US20070244120A1
公开(公告)日：2007-10-18
申请号：US11768112
申请日：2007-06-25
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号： A61K31/5377 , A61K31/09 , A61K31/136 , A61K31/381 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/426 , C07D401/12 , C07D231/10 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号： C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号：US20120046290A1
公开(公告)日：2012-02-23
申请号：US11932548
申请日：2007-10-31
申请人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
IPC分类号： A61K31/42 , A61K31/428 , A61K31/422 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/5377 , C07D261/14 , C07D231/40 , A61K31/415 , A61P29/00 , A61P19/02 , A61P19/10 , A61P11/06 , A61P1/00 , A61P31/00 , A61K31/4439
CPC分类号： C07D231/40 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D261/14 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
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9.发明授权Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas 失效使用芳基和杂芳基取代的杂环尿素抑制RAF激酶公开(公告)号：US07625915B2
公开(公告)日：2009-12-01
申请号：US11768533
申请日：2007-06-26
申请人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernard Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernard Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号： A61K31/415 , C07D231/38 , C07D403/12
CPC分类号： C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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10.发明申请Inhibition Of Raf Kinase Using Quinolyl, Isoquinolyl Or Pyridyl Ureas 审中-公开使用喹啉基，异喹啉基或吡啶基脲进行Raf激酶的抑制公开(公告)号：US20080194580A1
公开(公告)日：2008-08-14
申请号：US11932269
申请日：2007-10-31
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert N. Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David E. Gunn , Timotthy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert N. Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David E. Gunn , Timotthy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
IPC分类号： A61K31/496 , A61K31/444 , A61K31/44 , A61P35/00 , A61K31/47
CPC分类号： C07D213/40
摘要： This invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译： 本发明涉及一组喹啉基，异喹啉基和吡啶基脲，它们在治疗raf介导的疾病中的用途，以及包含用于这种治疗的这些尿素的药物组合物。
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