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    Furopyridine and furopyrimidine derivatives for the treatment of hyper-proliferative disorders
    7.
    发明申请
    Furopyridine and furopyrimidine derivatives for the treatment of hyper-proliferative disorders 失效
    呋喃啶和呋喃嘧啶衍生物用于治疗高增殖性疾病

    公开(公告)号：US20060040960A1

    公开(公告)日：2006-02-23

    申请号：US10515605

    申请日：2003-07-11

    申请人： Chengzhi Zhang ,  Gaetan Ladouceur ,  Michael Burke

    发明人： Chengzhi Zhang ,  Gaetan Ladouceur ,  Michael Burke

    IPC分类号： A61K31/519 ,  A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04 ,  A61K31/505

    摘要： This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each option-ally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.

    摘要翻译： 本发明涉及式（I）的化合物，其中Y是CH或N; Ar 1是苯基或吡啶基，其各自任选被1或2个各自独立地选自（C 1 -C 3 -C 3）烷氧基卤基，OH ，CF 3，CN，NO 2和（C 1 -C 3）烷基，所述烷基是任选的 用CF 3取代; Ar 2是每个选自1或2个独立地选自卤素，OH，CN，NO 2，CF 3或-NR 2的取代基的苯基或吡啶基， （C 1 -C 6）烷氧基，NR 1 R 1，S（O） C（O）R 3和（C 1 -C 6）烷基，C（O）R 3， 任选被R 4取代的，或其用于治疗高增殖性疾病的用途。

    Paint roller cleaning system
    9.
    发明授权
    Paint roller cleaning system 有权

    公开(公告)号：US11046108B2

    公开(公告)日：2021-06-29

    申请号：US15807523

    申请日：2017-11-08

    申请人： Michael Burke

    发明人： Michael Burke

    IPC分类号： B44D3/00

    摘要： A paint roller cleaning system including an elongated cylindrical member configured to receive a paint roller, a first-end-cap, and a second-end-cap. The first-end-cap for attachment at a first-end of the elongated cylindrical member and the second-end-cap for attachment at a second-end of the elongated cylindrical member. The first-end-cap includes a threaded-member and may couple to a water supply and direct water through a receiving-aperture. The second-end-cap includes an exit-aperture and a positioning-member for positioning the paint roller above the exit-aperture allowing for water to drain therethrough. The paint roller cleaning system may be used for cleaning a paint roller when inserted into the elongated cylindrical member and the water supply is activated.