公开(公告)号：US08932230B2

公开(公告)日：2015-01-13

申请号：US11348943

申请日：2006-02-06

申请人： Kevin Nason ,  Jonathan Fay ,  Bryan P. Flaherty ,  Bhairavi R. Parikh

发明人： Kevin Nason ,  Jonathan Fay ,  Bryan P. Flaherty ,  Bhairavi R. Parikh

IPC分类号： A61B5/08 ,  G01N33/497

CPC分类号： A61M16/085 ,  A61B5/0803 ,  A61B5/082 ,  A61B5/097 ,  A61M16/0003 ,  A61M16/0057 ,  A61M16/06 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2205/3331 ,  G01N33/497

摘要： The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

摘要翻译： 通过分析装置的呼出气体的气体样品的流量由泵控制，并且在某些实施例中由两个泵控制。 将分析物传感器放置在通过装置从主流分支的二次流中，进一步控制与传感器接触的呼吸的方式，持续时间和数量。

公开(公告)号：US20120232419A1

公开(公告)日：2012-09-13

申请号：US13479623

申请日：2012-05-24

申请人： David J Chazan ,  Bhairavi R Parikh ,  Bryan P Flaherty ,  David J Anvar ,  Brian A Awabdy

发明人： David J Chazan ,  Bhairavi R Parikh ,  Bryan P Flaherty ,  David J Anvar ,  Brian A Awabdy

IPC分类号： A61B5/097

CPC分类号： G01N33/0037 ,  G01N21/783 ,  G01N33/497 ,  Y02A50/245

摘要： A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NOx -free air in a controlled manner, preferably in pulses separated by equilibration periods.

摘要翻译： 呼吸密度高达200 ppb或以下的一氧化氮高灵敏度分析仪，含有细胞色素C的传感器具有多种用途，无需为每次使用安装新的传感器。 该功能通过在每次使用后通过以受控方式吹扫传感器和周围区域的无氧化物空气来实现，优选地以平衡周期分开的脉冲。

公开(公告)号：US08206311B2

公开(公告)日：2012-06-26

申请号：US12416760

申请日：2009-04-01

申请人： David J. Chazan ,  Bhairavi R. Parikh ,  Bryan P. Flaherty ,  David J. Anvar ,  Brian A. Awabdy

发明人： David J. Chazan ,  Bhairavi R. Parikh ,  Bryan P. Flaherty ,  David J. Anvar ,  Brian A. Awabdy

IPC分类号： A61B5/08 ,  G01N33/497

CPC分类号： G01N33/0037 ,  G01N21/783 ,  G01N33/497 ,  Y02A50/245

摘要： A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NOx-free air in a controlled manner, preferably in pulses separated by equilibration periods.

摘要翻译： 呼吸密度高达200 ppb或以下的一氧化氮高灵敏度分析仪，含有细胞色素C的传感器具有多种用途，无需为每次使用安装新的传感器。 该功能通过在每次使用后通过以受控方式吹扫传感器和周围区域以无NOx的空气，优选地以平衡周期分开的脉冲来再生分析器来实现。

公开(公告)号：US07611671B2

公开(公告)日：2009-11-03

申请号：US11250958

申请日：2005-10-14

申请人： David J. Anvar ,  David J. Chazan ,  Bryan P. Flaherty ,  Bhairavi R. Parikh

发明人： David J. Anvar ,  David J. Chazan ,  Bryan P. Flaherty ,  Bhairavi R. Parikh

IPC分类号： G01N33/497

CPC分类号： G01N21/783 ,  G01N21/76 ,  G01N33/0037 ,  G01N33/0059 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y02A50/245 ,  Y10T436/177692 ,  Y10T436/179228

摘要： Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.

摘要翻译： 通过将一氧化碳清除剂并入装置的内部或在装置包装中，用于检测气态样品中一氧化氮和/或其它气态分析物的高灵敏度装置得到改善。 通过用于建筑外壳中的塑料或释放一氧化碳的装置内的任何物质，在装置的壳体内释放一氧化碳导致由于一氧化碳和一氧化氮之间的竞争导致的结合的灵敏度损失 设备传感器上的站点。 清除剂通过催化一氧化碳氧化成竞争力较低的二氧化碳或通过亲和型或共价结合固定一氧化​​碳来纠正这一点。 对一氧化氮以外的分析物也能达到类似的效果，但同样遇到一氧化碳与传感器结合的干扰。

公开(公告)号：US20100256514A1

公开(公告)日：2010-10-07

申请号：US12416760

申请日：2009-04-01

申请人： David J. Chazan ,  Bhairavi R. Parikh ,  Bryan P. Flaherty ,  David J. Anvar ,  Brian A. Awabdy

发明人： David J. Chazan ,  Bhairavi R. Parikh ,  Bryan P. Flaherty ,  David J. Anvar ,  Brian A. Awabdy

IPC分类号： A61B5/08

CPC分类号： G01N33/0037 ,  G01N21/783 ,  G01N33/497 ,  Y02A50/245

摘要： A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NOx-free air in a controlled manner, preferably in pulses separated by equilibration periods.

摘要翻译： 呼吸密度高达200 ppb或以下的一氧化氮高灵敏度分析仪，含有细胞色素C的传感器可以多种用途，无需为每次使用安装新的传感器。 该功能通过在每次使用后通过以受控方式吹扫传感器和周围区域以无NOx的空气，优选地以平衡周期分开的脉冲来再生分析器来实现。