公开(公告)号：US08848654B2

公开(公告)日：2014-09-30

申请号：US11798702

申请日：2007-05-16

申请人： Yu Jun He ,  Steven Shio ,  Hai Rong Xie ,  Ming Bin Zheng

发明人： Yu Jun He ,  Steven Shio ,  Hai Rong Xie ,  Ming Bin Zheng

IPC分类号： H04W4/00 ,  H04W16/32

CPC分类号： H04W16/32

摘要： A first pilot signal is transmitted at a first frequency for a first coverage area (e.g., an outdoor area). A second pilot signal is transmitted at a second frequency for a second coverage area (e.g., an indoor area). The first pilot signal at the second frequency is transmitted into a portion of the second coverage area, the second coverage area at least overlapping with the first coverage area. Further, the first pilot signal is transmitted at the second frequency in the second coverage area. In an example, the first pilot signal at the first frequency is transmitted from an outdoor base station, the second pilot signal at the second frequency is transmitted by an indoor base station, the first pilot signal at the second frequency is transmitted into the second coverage area (e.g., an interior of a building from a building exit point) by an antenna (e.g., not necessarily at a base station) and the second pilot signal at the first frequency is transmitted by the indoor base station. The pilot signal configuration discussed above may facilitate call handoffs between the first and second coverage areas. For example, if the first coverage area is an outdoor area and the second coverage area is a building interior, the example pilot signal configuration may reduce pilot pollution.

摘要翻译： 对于第一覆盖区域（例如，室外区域）以第一频率发送第一导频信号。 以第二频率发送第二导频信号用于第二覆盖区域（例如，室内区域）。 第二频率的第一导频信号被发送到第二覆盖区域的一部分，第二覆盖区域至少与第一覆盖区域重叠。 此外，在第二覆盖区域中以第二频率发送第一导频信号。 在一个例子中，从户外基站发送第一频率的第一导频信号，由室内基站发送第二频率的第二导频信号，将第二频率的第一导频信号发送到第二频带 通过天线（例如，不一定在基站处），区域（例如，建筑物出口点的建筑物的内部）和第一频率的第二导频信号由室内基站发送。 上述导频信号配置可以促进第一和第二覆盖区域之间的呼叫切换。 例如，如果第一覆盖区域是户外区域，并且第二覆盖区域是建筑物内部，则示例导频信号配置可以减少导频污染。

公开(公告)号：US20120267258A1

公开(公告)日：2012-10-25

申请号：US13452466

申请日：2012-04-20

申请人： Yukiharu URAOKA ,  Bin Zheng ,  Seigo SUZUKI ,  Hiroya KIRIMURA ,  Masayoshi SEIKE ,  Shigeki IWANAGA ,  Nobuyasu HORI

发明人： Yukiharu URAOKA ,  Bin Zheng ,  Seigo SUZUKI ,  Hiroya KIRIMURA ,  Masayoshi SEIKE ,  Shigeki IWANAGA ,  Nobuyasu HORI

IPC分类号： G01N27/26

CPC分类号： G01N33/5438 ,  G01N27/3275

摘要： In order to provide a method for electrochemically detecting an analyte which can detect an analyte with high detection sensitivity, when detecting an analyte S trapped on a working electrode, a label binding substance 90 in which a labeling substance 93 and a first binding substance 92 which traps the analyte S are at least retained on a support 91 composed of polypeptide is brought into contact with the analyte. Alternatively, a complex containing the analyte S and a label binding substance 290 in which a labeling substance 293 is retained on a binding substance 291 which binds to the analyte S via a modulator 292 is formed. Then, the labeling substance present on the working electrode is electrochemically detected.

摘要翻译： 为了提供用于电化学检测能够检测具有高检测灵敏度的分析物的分析物的方法，当检测到捕获在工作电极上的分析物S时，将标记物质93和第一结合物质92 截留分析物S至少保留在由多肽组成的支撑体91上与分析物接触。 或者，形成包含分析物S和标记结合物质290的复合物，其中标记物质293保留在结合物质291上，结合物质291经由调节器292与分析物S结合。 然后，电化学地检测存在于工作电极上的标记物质。

公开(公告)号：US20080159226A1

公开(公告)日：2008-07-03

申请号：US11798702

申请日：2007-05-16

申请人： Yu Jun He ,  Steven Shio ,  Hai Rong Xie ,  Ming Bin Zheng

发明人： Yu Jun He ,  Steven Shio ,  Hai Rong Xie ,  Ming Bin Zheng

IPC分类号： H04Q7/00

CPC分类号： H04W16/32

摘要： A first pilot signal is transmitted at a first frequency for a first coverage area (e.g., an outdoor area). A second pilot signal is transmitted at a second frequency for a second coverage area (e.g., an indoor area). The first pilot signal at the second frequency is transmitted into a portion of the second coverage area, the second coverage area at least overlapping with the first coverage area. Further, the first pilot signal is transmitted at the second frequency in the second coverage area. In an example, the first pilot signal at the first frequency is transmitted from an outdoor base station, the second pilot signal at the second frequency is transmitted by an indoor base station, the first pilot signal at the second frequency is transmitted into the second coverage area (e.g., an interior of a building from a building exit point) by an antenna (e.g., not necessarily at a base station) and the second pilot signal at the first frequency is transmitted by the indoor base station. The pilot signal configuration discussed above may facilitate call handoffs between the first and second coverage areas. For example, if the first coverage area is an outdoor area and the second coverage area is a building interior, the example pilot signal configuration may reduce pilot pollution.

摘要翻译： 对于第一覆盖区域（例如，室外区域）以第一频率发送第一导频信号。 以第二频率发送第二导频信号用于第二覆盖区域（例如，室内区域）。 第二频率的第一导频信号被发送到第二覆盖区域的一部分，第二覆盖区域至少与第一覆盖区域重叠。 此外，在第二覆盖区域中以第二频率发送第一导频信号。 在一个例子中，从户外基站发送第一频率的第一导频信号，由室内基站发送第二频率的第二导频信号，将第二频率的第一导频信号发送到第二频带 通过天线（例如，不一定在基站处），区域（例如，建筑物出口点的建筑物的内部）和第一频率的第二导频信号由室内基站发送。 上述导频信号配置可以促进第一和第二覆盖区域之间的呼叫切换。 例如，如果第一覆盖区域是户外区域，并且第二覆盖区域是建筑物内部，则示例导频信号配置可以减少导频污染。

公开(公告)号：US20070129311A1

公开(公告)日：2007-06-07

申请号：US10559410

申请日：2004-05-28

申请人： Donald Creighton ,  Zhe-bin Zheng

发明人： Donald Creighton ,  Zhe-bin Zheng

IPC分类号： A61K38/05 ,  C07K5/10

CPC分类号： C07K7/02 ,  A61K38/00 ,  A61K47/55 ,  A61K47/60 ,  A61K47/64 ,  C07K5/0202 ,  C07K5/0215

摘要： Compounds comprising two human GlxI inhibitors covalently linked via a chemical linker are provided, wherein each of said two human GlxI inhibitors, which may be the same or different, is an S-substituted glutathione or an S-substituted glutathione prodrug, wherein said GlxI inhibitors each have a γ-glutamyl amino group, wherein said chemical linker is covalently bound to each GlxI inhibitor via said γ-glutamyl amino group, and wherein said chemical linker has a length of at least 50 Angstroms. Monovalent irreversible inactivators of human GlxI are also provided. An antineoplastic composition is provided, which comprises a compound described above and a pharmaceutically acceptable carrier. In vitro and in vivo methods of preventing or inhibiting the growth and proliferation of neoplastic cells and/or tumors are also provided.

摘要翻译： 提供了包含通过化学接头共价连接的两个人GlxI抑制剂的化合物，其中所述两种可以相同或不同的人类GlxI抑制剂中的每一种都是S-取代的谷胱甘肽或S-取代的谷胱甘肽前药，其中所述GlxI抑制剂 每个具有γ-谷氨酰氨基，其中所述化学连接体经由所述γ-谷氨酰氨基与每个GlxI抑制剂共价结合，并且其中所述化学连接体具有至少50埃的长度。 还提供了人GlxI的单价不可逆灭活剂。 提供抗肿瘤组合物，其包含上述化合物和药学上可接受的载体。 还提供了预防或抑制肿瘤细胞和/或肿瘤的生长和增殖的体外和体内方法。

公开(公告)号：US07102001B2

公开(公告)日：2006-09-05

申请号：US11008719

申请日：2004-12-09

申请人： Shankar Swaminathan ,  Ashvinikumar V. Gavai ,  Junying Fan ,  Bharat P. Patel ,  Derek J. Norris ,  Richard Michael Corbett ,  Bin Zheng

发明人： Shankar Swaminathan ,  Ashvinikumar V. Gavai ,  Junying Fan ,  Bharat P. Patel ,  Derek J. Norris ,  Richard Michael Corbett ,  Bin Zheng

IPC分类号： C07D487/14 ,  C07D413/14 ,  C07D403/12 ,  A61K31/53 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention provides a process for preparing compounds of formula (I) or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

摘要翻译： 本发明提供制备式（I）化合物或其药学上可接受的盐的方法。 通过本发明的方法制备的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。

公开(公告)号：US20050209454A1

公开(公告)日：2005-09-22

申请号：US11008719

申请日：2004-12-09

申请人： Shankar Swaminathan ,  Ashvinikumar Gavai ,  Junying Fan ,  Bharat Patel ,  Derek Norris ,  Richard Corbett ,  Bin Zheng

发明人： Shankar Swaminathan ,  Ashvinikumar Gavai ,  Junying Fan ,  Bharat Patel ,  Derek Norris ,  Richard Corbett ,  Bin Zheng

IPC分类号： A61K20060101 ,  A61K31/53 ,  A61P35/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The present invention provides a process for preparing compounds of formula (I) or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

摘要翻译： 本发明提供制备式（I）化合物或其药学上可接受的盐的方法。 通过本发明的方法制备的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。

公开(公告)号：US06278793B1

公开(公告)日：2001-08-21

申请号：US09118366

申请日：1998-07-17

申请人： David Gur ,  Bin Zheng

发明人： David Gur ,  Bin Zheng

IPC分类号： G06K900

CPC分类号： G06T7/0012 ,  G06K9/3233 ,  G06T2207/10116 ,  G06T2207/30068

摘要： A computerized method of detecting regions of interest in a digital image optimizes and adapts a computer aided scheme for detecting regions of interest in images. The optimization is based on global image characteristics. For each image in a database of images having known regions of interest, global image features are measured and an image characteristic index is established based on these global image features. All the images in the database are divided into a number of image groups based on the image characteristic index of each image in the database and the CAD scheme is optimized for each image group. Once the CAD scheme is optimized, to process a digital image, an image characteristics based classification criteria is established for that image, and then global image features of the digitized image are determined. The digitized image is then assigned an image characteristics rating based on the determined global image features, and the image is assigned to an image group based on the image rating. Then regions of interest depicted in the image are determined using a detection scheme adapted for the assigned image group.

摘要翻译： 用于检测数字图像中的感兴趣区域的计算机化方法优化并适配用于检测图像中感兴趣区域的计算机辅助方案。 优化是基于全局图像特征。 对于具有已知感兴趣区域的图像的数据库中的每个图像，测量全局图像特征，并且基于这些全局图像特征建立图像特征索引。 基于数据库中每个图像的图像特征索引将数据库中的所有图像分成多个图像组，并且针对每个图像组优化CAD方案。 一旦CAD方案被优化，为了处理数字图像，为该图像建立基于图像特征的分类标准，然后确定数字化图像的全局图像特征。 然后，基于所确定的全局图像特征向数字化图像分配图像特征等级，并且基于图像评级将图像分配给图像组。 然后，使用适于所分配的图像组的检测方案来确定图像中描绘的感兴趣区域。

公开(公告)号：US5627907A

公开(公告)日：1997-05-06

申请号：US352169

申请日：1994-12-01

申请人： David Gur ,  Bin Zheng ,  Yuang-Hsiang Chang

发明人： David Gur ,  Bin Zheng ,  Yuang-Hsiang Chang

IPC分类号： G06K9/00 ,  G06T7/00

CPC分类号： G06T7/0012 ,  G06K9/00127

摘要： Method and apparatus for detecting abnormal regions such as masses and microcalcifications in living tissue depicted in radiographs such as mammograms is presented by digitizing the radiograph to produce a digitized radiograph, and, by computer, identifying, according to predetermined criteria, any suspected abnormal regions; and for each identified suspected abnormal region, extracting multiple topographic layers of the region from the digitized radiograph; and evaluating the extracted multiple topographic layers' abnormal regions to determine whether the region is an abnormal region; and displaying the abnormal regions in a version of the radiograph. Layers are extracted by thresholding the digital radiograph at a particular threshold value for each topographic layer. The threshold value for each other layer is based on the threshold and contrast values in a previous layer.

摘要翻译： 通过数字化放射照片来产生数字化的放射照片，并且通过计算机根据预定的标准识别任何可疑的异常区域来呈现用于检测诸如乳房X线照片之类的放射线照片中描绘的生物组织中的质量和微钙化异常区域的方法和装置。 并针对每个识别出的疑似异常区域，从数字化的X光照片中提取该地区的多个地形图; 并评估提取的多个地形图层的异常区域，以确定该区域是否为异常区域; 并在放射照片的版本中显示异常区域。 通过对每个地形图层的特定阈值阈值化数字X射线照片来提取层。 每个其他层的阈值基于上一层中的阈值和对比度值。

公开(公告)号：US07700560B2

公开(公告)日：2010-04-20

申请号：US10559410

申请日：2004-05-28

申请人： Donald J. Creighton ,  Zhe-Bin Zheng

发明人： Donald J. Creighton ,  Zhe-Bin Zheng

IPC分类号： A61K38/08 ,  C07K5/02 ,  C07K5/08 ,  C07K5/10

CPC分类号： C07K7/02 ,  A61K38/00 ,  A61K47/55 ,  A61K47/60 ,  A61K47/64 ,  C07K5/0202 ,  C07K5/0215

摘要： Compounds comprising two human GlxI inhibitors covalently linked via a chemical linker are provided, wherein each of said two human GlxI inhibitors, which may be the same or different, is an S-substituted glutathione or an S-substituted glutathione prodrug, wherein said GlxI inhibitors each have a γ-glutamyl amino group, wherein said chemical linker is covalently bound to each GlxI inhibitor via said γ-glutamyl amino group, and wherein said chemical linker has a length of at least 50 Angstroms. Monovalent irreversible inactivators of human GlxI are also provided. An antineoplastic composition is provided, which comprises a compound described above and a pharmaceutically acceptable carrier. In vitro and in vivo methods of preventing or inhibiting the growth and proliferation of neoplastic cells and/or tumors are also provided.

摘要翻译： 提供了包含通过化学接头共价连接的两个人GlxI抑制剂的化合物，其中所述两种可以相同或不同的人类GlxI抑制剂中的每一种都是S-取代的谷胱甘肽或S-取代的谷胱甘肽前药，其中所述GlxI抑制剂 每个具有γ-谷氨酰氨基，其中所述化学连接体经由所述γ-谷氨酰氨基共价结合到每个GlxI抑制剂，并且其中所述化学连接体具有至少50埃的长度。 还提供了人GlxI的单价不可逆灭活剂。 提供抗肿瘤组合物，其包含上述化合物和药学上可接受的载体。 还提供了预防或抑制肿瘤细胞和/或肿瘤的生长和增殖的体外和体内方法。

公开(公告)号：US07324861B1

公开(公告)日：2008-01-29

申请号：US11564969

申请日：2006-11-30

申请人： Chun Bin Zheng

发明人： Chun Bin Zheng

IPC分类号： G06F19/00

CPC分类号： H05K3/1225 ,  G05B2219/45029 ,  G05B2219/45041 ,  H05K2203/107

摘要： A numerical control system for laser cutting an SMT stencil includes a mechanical control portion (2) and a laser control portion (3). The mechanical control portion includes a first main control system (21), a first host computer isolation interface (22), a first communication interface controller (24), a first optoelectronic/magnetic isolator (25), and a first isolated input/output interface (23) coupled to a mechanical transmission device. Similarly, the laser control portion includes a second main control system (31), a second host computer isolation interface (32), a second communication interface controller (34), a second optoelectronic/magnetic isolator (35), and a second isolated input/output interface (33) coupled to a laser cutting device. The first and second main control systems are connected with the host computer via the respective first and second host computer isolation interfaces. The first and second optoelectronic/magnetic isolators are connected with a slave computer. The numerical control system can be further divided into a cutting management module (4) and a stencil output module (5). A numerical control method associated with the above numerical control system for laser cutting an SMT stencil is also disclosed.

摘要翻译： 用于激光切割SMT模板的数控系统包括机械控制部分（2）和激光控制部分（3）。 机械控制部分包括第一主控制系统（21），第一主机隔离接口（22），第一通信接口控制器（24），第一光电/磁隔离器（25）和第一隔离输入/输出 接口（23）耦合到机械传动装置。 类似地，激光控制部分包括第二主控制系统（31），第二主计算机隔离接口（32），第二通信接口控制器（34），第二光电子/磁隔离器（35）和第二隔离输入 /输出接口（33），其耦合到激光切割装置。 第一和第二主控制系统通过相应的第一和第二主机隔离接口与主计算机连接。 第一和第二光电/磁隔离器与从属计算机连接。 数控系统可以进一步分为切割管理模块（4）和模板输出模块（5）。 还公开了一种与上述用于激光切割SMT模板的数控系统相关联的数字控制方法。