公开(公告)号：US20040132166A1

公开(公告)日：2004-07-08

申请号：US10664046

申请日：2003-09-16

Applicant: BioProcessors Corp.

Inventor： Scott E. Miller ,  Gennady Malin ,  Howard B. Schreyer ,  Seth T. Rodgers ,  Andrey J. Zarur

IPC: C12M001/34

CPC classification number: C12M23/16 ,  B01L3/502707 ,  B01L7/00 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/10 ,  B01L2300/1822 ,  B01L2300/1827

Abstract: The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

Abstract translation: 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

公开(公告)号：US20040121454A1

公开(公告)日：2004-06-24

申请号：US10633448

申请日：2003-08-01

Applicant: BioProcessors Corp.

Inventor： Andrey Zarur Jury ,  Mark D. Angelino

IPC: C12M001/00

CPC classification number: B01F13/0064 ,  B01F5/0256 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0094 ,  B01F15/00935 ,  B01F2005/0621 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/00862 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00966 ,  C12M23/16

Abstract: Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of the reactors can be readily formed from a variety of materials. For example, they can be etched from silicon. Components are connectable to and separable from each other to form a variety of types of reactors, and the reactors can be attachable to and separable from each other to add significant flexibility in parallel and/or series reactor operation.

Abstract translation: 提供化学和生物反应堆，包括微反应器。 示例性反应器包括可并行操作的多个反应器，其中每个反应器具有小体积，并且一起反应器产生大体积的产物。 反应系统可以包括混合室，加热/分散单元，反应室和分离单元。 反应器的组分可以容易地由各种材料形成。 例如，它们可以从硅上蚀刻。 组件可彼此连接并可分离以形成各种类型的反应器，并且反应器可以彼此附接和分离，以在并联和/或串联反应器操作中增加显着的灵活性。