公开(公告)号：US20040185553A9

公开(公告)日：2004-09-23

申请号：US10011202

申请日：2001-12-07

发明人： Derek J. Hei

IPC分类号： C12M003/00 ,  C12M001/00 ,  B01D015/08

CPC分类号： B01J20/28026 ,  A01N1/0205 ,  A01N1/0236 ,  A01N1/0242 ,  A01N1/0278 ,  A61L2/00 ,  A61L2/0082 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/3679 ,  B01D15/00 ,  B01J20/20 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28028 ,  B01J20/28057 ,  B01J20/28078 ,  C07D219/10 ,  C07D405/12 ,  C07D493/04 ,  C07F9/64 ,  C12N11/08

摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

摘要翻译： 提供的方法和装置用于降低含有细胞的生物组合物中的低分子量化合物的浓度，同时基本保持生物组合物的所需生物活性。 该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。

公开(公告)号：US20040137609A1

公开(公告)日：2004-07-15

申请号：US10476454

申请日：2003-10-31

发明人： Ilia Borisovitch Izvoztchikov ,  Helge Ebeling

IPC分类号： C12M001/00

CPC分类号： G01N1/31

摘要： The invention relates to a treatment compartment (1) for treating histological samples with treating agents (2, 2null, 2null). Said treatment compartment (1) comprises a housing (3) with an inlet and outlet (4, 4null) for the treating agents (2, 2null, 2null), a rotatable retaining device (5) which receives the samples and a closable access opening (6) on the front (7). The aim of the invention is to improve a treatment compartment (1) of the above kind in such a way that it has a compact design and is easily accessible without the risk of the treating agents (2, 2null, 2null) emerging. According to the invention, the housing (3) is designed and mounted in such a manner and at least the lower zone of the front (7) is provided with such a rim (8) that a liquid level (9) of the treating agents (2, 2null, 2null) can be formed even when the access opening (6) is open, and that the sample is held in the retaining device (5) in such a way that it can be moved, when the retaining device rotates, through the treating agents (2, 2null, 2null) forming the liquid level (9).

摘要翻译： 本发明涉及用治疗剂（2,2'，2“）治疗组织学样品的治疗室（1）。 所述处理室（1）包括具有用于处理剂（2,2'，2“）的入口和出口（4,4'）的壳体（3），可接收样品的可旋转保持装置（5） 在前部（7）上的可关闭的进入开口（6）。 本发明的目的是改进上述类型的治疗室（1），使其具有紧凑的设计并且易于接近，而没有处理剂（2,2'，2“）出现的风险 。 根据本发明，壳体（3）以这种方式设计和安装，并且至少前部（7）的下部区域设置有这样的边缘（8），即处理剂的液面（9） 即使当进入开口（6）打开时，也可以形成（2,2'，2“），并且当保持件（6）打开时，样品被保持在保持装置（5）中，使得其可以移动 装置通过形成液位（9）的处理剂（2,2'，2“）旋转。

公开(公告)号：US20040121454A1

公开(公告)日：2004-06-24

申请号：US10633448

申请日：2003-08-01

申请人： BioProcessors Corp.

发明人： Andrey Zarur Jury ,  Mark D. Angelino

IPC分类号： C12M001/00

CPC分类号： B01F13/0064 ,  B01F5/0256 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0094 ,  B01F15/00935 ,  B01F2005/0621 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/00862 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00966 ,  C12M23/16

摘要： Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of the reactors can be readily formed from a variety of materials. For example, they can be etched from silicon. Components are connectable to and separable from each other to form a variety of types of reactors, and the reactors can be attachable to and separable from each other to add significant flexibility in parallel and/or series reactor operation.

摘要翻译： 提供化学和生物反应堆，包括微反应器。 示例性反应器包括可并行操作的多个反应器，其中每个反应器具有小体积，并且一起反应器产生大体积的产物。 反应系统可以包括混合室，加热/分散单元，反应室和分离单元。 反应器的组分可以容易地由各种材料形成。 例如，它们可以从硅上蚀刻。 组件可彼此连接并可分离以形成各种类型的反应器，并且反应器可以彼此附接和分离，以在并联和/或串联反应器操作中增加显着的灵活性。

公开(公告)号：US20040110272A1

公开(公告)日：2004-06-10

申请号：US10722976

申请日：2003-11-26

发明人： Koji Fujita

IPC分类号： C12M001/00

CPC分类号： G01N21/0303 ,  B01L3/5085 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/168

摘要： A biochemical vessel has a plurality of sample holding cells juxtaposed one next to another. Each cell has a light transparent bottom. Each sample holding cell includes, in its inner side, a light reflecting face which extends radially away from the axis of the cell as the reflecting face extends downwards.

摘要翻译： 生化容器具有多个彼此并列的样品保持细胞。 每个单元都有一个透明的底部。 每个样品保持单元在其内侧包括当反射面向下延伸时从电池的轴线径向延伸的光反射面。

公开(公告)号：US20040067577A1

公开(公告)日：2004-04-08

申请号：US10265715

申请日：2002-10-08

发明人： Wilbur W. Wilson ,  Charles S. Henry ,  Carlos D. Garcia

IPC分类号： C12M001/00 ,  C12Q001/00

CPC分类号： B01L3/5027 ,  B01L2200/12 ,  B01L2300/0877 ,  B01L2300/0887 ,  G01N30/6095

摘要： A micro-fluidic device having a cavity containing a solid support (e.g., a plurality of particles) and a biomolecule immobilized on a surface of the solid support is provided. The micro-fluidic device can be used to monitor interactions between a biomolecule in a sample and the biomolecule immobilized on the solid support. For example, the micro-fluidic device can be used to monitor protein self-interactions wherein the protein in the sample is the same protein as that immobilized on the surface of the solid support. A method of making the micro-fluidic device is also described. The micro-fluidic device can be used for chromatographic applications where sample consumption is crucial.

摘要翻译： 提供了具有包含固体支持物（例如，多个颗粒）的空腔和固定在固体支持物的表面上的生物分子的微流体装置。 微流体装置可以用于监测样品中的生物分子与固定在固体支持物上的生物分子之间的相互作用。 例如，微流体装置可用于监测蛋白质自身相互作用，其中样品中的蛋白质与固定在固体支持物表面上的蛋白质相同。 还描述了制造微流体装置的方法。 微流体装置可用于样品消耗至关重要的色谱应用。

公开(公告)号：US20040066199A1

公开(公告)日：2004-04-08

申请号：US10455784

申请日：2003-06-06

发明人： Paul A. Rhodes

IPC分类号： G01N027/26 ,  C12M001/00

CPC分类号： C07K14/705

摘要： A method of using experimental data determines the structure and voltage dependence of transition rates for states in models of ion channels.

摘要翻译： 使用实验数据的方法确定离子通道模型中状态的转变速率的结构和电压依赖性。

公开(公告)号：US20040060818A1

公开(公告)日：2004-04-01

申请号：US10662081

申请日：2003-09-12

申请人： TheraSense, Inc.

发明人： Benjamin J. Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph A. Vivolo ,  Jeffery V. Funderburk ,  Fredric C. Colman ,  Rajesh Krishnan

IPC分类号： C12M001/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：US20040023370A1

公开(公告)日：2004-02-05

申请号：US10398957

申请日：2003-08-22

发明人： Hanry Yu ,  Kam Leong ,  Ser-Mien Chia

IPC分类号： C12M001/00

CPC分类号： C12N5/0062 ,  A61K2035/128 ,  C12N5/0012 ,  C12N5/0671 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2533/72 ,  Y10S514/963 ,  Y10S514/97

摘要： A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good environment for culturing or co-culturing anchorage-dependent cells. The cells cultured this manner can be readily used in such applications as cell transplantation, tissue engineering seeding of cells on scaffolds, and other applications that require immediate availability of functioning cells.

摘要翻译： 无破坏性的三维培养系统允许三维细胞生长和增殖，允许细胞分裂而不使细胞受到影响细胞结构和功能的破坏性条件。 细胞外基质提供培养或共培养锚定依赖性细胞的良好环境。 以这种方式培养的细胞可以容易地用于诸如细胞移植，在支架上细胞的组织工程接种以及需要立即获得功能性细胞的其它应用的应用。

公开(公告)号：US20040016274A1

公开(公告)日：2004-01-29

申请号：US10415060

申请日：2003-04-25

发明人： Thomasz Rudas

IPC分类号： C12M001/00

CPC分类号： C05F17/027 ,  C05F17/0072 ,  Y02P20/145 ,  Y02W30/43

摘要： A method and an apparatus is provided for aeration of organic material, wherein the organic material undergoes an aerobic composting process, such that air is caused to evenly penetrate the organic material. The organic material is first sealed in a vessel. Air is then delivered to the contents of the vessel such that an air pressure of from about 1 to about 1000 kPa above atmospheric pressure is maintained in the vessel. A pressure differential initially forms and is then allowed to equilibrate over a period of time, in which time air flows from areas of high pressure to areas of low pressure in the organic material thus ensuring that aeration is evenly distributed throughout the organic material.

摘要翻译： 提供了一种用于曝气有机材料的方法和装置，其中有机材料进行有氧堆肥过程，使空气均匀地渗入有机材料。 首先将有机材料密封在容器中。 然后将空气输送到容器的内容物，使得容器中保持大气压大约1至大约1000kPa的空气压力。 最初形成压差并在一段时间内使其平衡，此时空气从有机材料中的高压区域到低压区域流动，从而确保曝气均匀分布在整个有机材料中。

公开(公告)号：US20030207443A1

公开(公告)日：2003-11-06

申请号：US10410010

申请日：2003-04-08

发明人： Russell Anthony Ritter ,  Anthony Martin Niederberger ,  Barry James Smith ,  Mike Lotzof ,  Kelvin Bannister

IPC分类号： C12M001/00

CPC分类号： A01K67/0332 ,  C02F3/327 ,  C02F11/02 ,  C05F17/0009 ,  C05F17/02 ,  Y02P20/145 ,  Y02W10/18 ,  Y02W10/27 ,  Y02W30/43

摘要： Apparatus suitable for use in the treatment of waste and/or organic materials which includes a main body having a treatment chamber therein having a base which when the apparatus is in a harvesting mode is arranged with a space there below. The base includes a plurality of generally parallel spaced apart support elements, the support elements being spaced apart at a distance sufficient to support the material within the chamber during the treatment process and enable extraction of the treated material through the spaces between the support elements during a harvesting process. There is also disclosed a harvesting device comprising a plurality of extraction elements which are adapted to project through the spaces between the support elements to dislodge and extract the treated material through the base. The apparatus and harvesting device is particularly useful for removing worm casting in vermiculture.

摘要翻译： 适用于处理废物和/或有机材料的装置，其包括具有处理室的主体，所述处理室具有当所述装置处于收获模式时的基部，所述基部在其下方具有空间。 底座包括多个大致平行间隔开的​​支撑元件，支撑元件间隔开足以在处理过程期间支撑腔室内的材料，并且能够在处理过程中通过支撑元件之间的空间抽出被处理材料 收获过程。 还公开了一种收获装置，其包括多个提取元件，其适于突出穿过支撑元件之间的空间，以通过基底移除和提取经处理的材料。 该设备和收获装置特别适用于除去蛭石中的蠕虫。