公开(公告)号：US20060257424A1

公开(公告)日：2006-11-16

申请号：US10480565

申请日：2002-06-14

申请人： Glenn Browning ,  Kelly Tivendale ,  Peter Scott ,  Hayley Brown ,  Brendan Crabb ,  Michelle Peters

发明人： Glenn Browning ,  Kelly Tivendale ,  Peter Scott ,  Hayley Brown ,  Brendan Crabb ,  Michelle Peters

IPC分类号： A61K39/12 ,  C12N7/00

CPC分类号： C12N7/00 ,  A61K2039/525 ,  C12N2750/10061

摘要： An isolated attenuated circovirus having a mutation in viral nucleic acid encoding viral protein 2 (VP2). The attenuated circovirus is particularly suitable for use in conferring immunity in an animal, particularly birds.

摘要翻译： 具有编码病毒蛋白2（VP2）的病毒核酸突变的分离的减毒圆环病毒。 减毒圆环病毒特别适用于赋予动物，特别是鸟类免疫力。

公开(公告)号：US20060234317A1

公开(公告)日：2006-10-19

申请号：US10504177

申请日：2003-02-11

申请人： Rebecca O'Donnell ,  Tania De Koning-Ward ,  Brendan Crabb

发明人： Rebecca O'Donnell ,  Tania De Koning-Ward ,  Brendan Crabb

IPC分类号： A61K49/00 ,  G01N33/569 ,  C12N1/10

CPC分类号： C07K16/205 ,  C07K14/445 ,  G01N33/56905 ,  G01N33/6854 ,  G01N2333/445

摘要： A method of detecting the presence of a functionally inhibitory immunointeractive molecule in a biological sample. Preferably, the immunointeractive molecule is directed to a pathogen derived antigen and, more particularly, a parasite derived antigen and, even more particularly, a Plasmodium drived antigen. The method of the present invention facilitates detection of the presence of functionally inhibitory immunointeractive molecules, both in vitro and in vivo, and is useful for qualitatively and/or quantitatively assessing the immune status of individuals who have been previously infected with a parasite, predicting the immune status of individuals vaccinated with an antigen based vaccine, determining the relative contribution of a specific immunoreactivity of antibody to the total inhibitory antibody elicited by combination vaccines which include two or more antigens, assessing vaccines to determine the efficacy of different forms of an antigen, determining vaccine potency, assessing the protective potential of certain immunoreactivities of antibodies and determining the importance of parasite inhibitory antibodies.

摘要翻译： 检测生物样品中功能性抑制性免疫反应性分子的存在的方法。 优选地，免疫相互作用分子针对病原体衍生的抗原，更具体地，涉及寄生虫衍生的抗原，甚至更特别地是疟原虫驱动的抗原。 本发明的方法有助于在体外和体内检测功能性抑制性免疫反应性分子的存在，并且可用于定性和/或定量评估先前已被寄生虫感染的个体的免疫状态，预测 用基于抗原的疫苗接种的个体的免疫状态，确定抗体对由包含两种或多种抗原的组合疫苗引起的总抑制性抗体的特异性免疫反应性的相对贡献，评估疫苗以确定不同形式的抗原的功效， 确定疫苗效力，评估抗体的某些免疫反应性的保护潜力并确定寄生虫抑制性抗体的重要性。

公开(公告)号：US20080107656A1

公开(公告)日：2008-05-08

申请号：US11756487

申请日：2007-05-31

申请人： Brendan Crabb ,  Paul Sanders

发明人： Brendan Crabb ,  Paul Sanders

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61P33/02 ,  C07H21/00 ,  C07K16/00 ,  C12N15/63 ,  C40B40/08 ,  C12N1/00 ,  C07K14/00 ,  A61P33/06 ,  A61K38/16

CPC分类号： C07K16/205 ,  A61K38/00 ,  C07K14/445 ,  Y02A50/412

摘要： The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism and compositions for use therein. More particularly, the present invention relates to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism by administering an immunogenic composition comprising one or more of Pf38, Pf12, Pf41, Pf92 or Pf113 or immunogenic fragment or homologue thereof. The present invention is useful, inter alia, as a prophylactic and/or therapeutic treatment for Plasmodium infections of mammals such as, for example, Plasmodium falciparum infection.

摘要翻译： 本发明一般涉及引发或以其它方式诱导对疟原虫微生物的免疫应答的方法及其中使用的组合物。 更具体地，本发明涉及通过施用包含Pf38，Pf12，Pf41，Pf92或Pf113中的一种或多种的免疫原性组合物或其免疫原性片段或同源物来引发或以其它方式诱导对疟原虫微生物的免疫应答的方法。 本发明尤其可用作哺乳动物（例如恶性疟原虫感染）的疟原虫感染的预防和/或治疗性治疗。