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公开(公告)号：US20140186393A1
公开(公告)日：2014-07-03
申请号：US14135791
申请日：2013-12-20
申请人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Christine Margaret MUEHLENTHALER , Axel NEUBAUER , Arun V. IYER
发明人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Christine Margaret MUEHLENTHALER , Axel NEUBAUER , Arun V. IYER
CPC分类号： A61K39/0241 , A61K35/22 , A61K2039/70
摘要： The present invention relates to an immunogenic composition comprising: a) one or more antigen of M. hyorhinis and one or more antigens of M. hyosynoviae; and b) a pharmaceutically acceptable carrier. Furthermore, the present invention relates to an immunogenic composition that comprises a) one or more mycoplasma antigens of mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae; and b) one or more components of a eukaryotic cell system. Moreover, the present invention also provides an immunogenic composition obtained by a method comprising a) cultivation of a mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae in a serum-reduced, eukaryotic cell system; b) obtaining an antigen of such mycoplasma bacteria; and c) addition of a pharmaceutically acceptable carrier.
摘要翻译： 本发明涉及一种免疫原性组合物，其包含：a）一种或多种羊水藓的抗原和一种或多种hy蛇科的抗原; 和b）药学上可接受的载体。 此外，本发明涉及免疫原性组合物，其包含a）一种或多种支原体细菌的支原体抗原，所述支原体抗原选自湿of属，猪肺炎支原体和hy蛇科; 和b）真核细胞系统的一种或多种组分。 此外，本发明还提供了一种通过以下方法获得的免疫原性组合物，所述方法包括：a）在血清还原的真核细胞系统中培养选自由猪肺炎支原体，猪肺炎支原体和猪hy属细菌组成的组的支原体细菌; b）获得这种支原体细菌的抗原; 和c）加入药学上可接受的载体。
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公开(公告)号：US09273281B2
公开(公告)日：2016-03-01
申请号：US14135796
申请日：2013-12-20
申请人： Dianna M. Murphy Jordan , Brian Thomas Martinson , Christine Margaret Muehlenthaler , Axel Neubauer , Arun V. Iyer
发明人： Dianna M. Murphy Jordan , Brian Thomas Martinson , Christine Margaret Muehlenthaler , Axel Neubauer , Arun V. Iyer
IPC分类号： G01N33/554 , G01N33/569 , C12N1/20 , A61K39/02 , C12N1/36 , A61K39/00
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , C12N1/20 , C12N1/36 , C12N5/0686 , C12N2502/70
摘要： The present invention relates to a method for the preparation of an immunogenic composition for the treatment and/or prophylaxis of mycoplasma infections in a subject comprising the cultivation of mycoplasma bacteria in a serum-reduced or swine serum-free, eukaryotic cell system; obtaining an antigen of the mycoplasma bacteria; and addition of a pharmaceutically acceptable carrier. Further, the present invention relates to the immunogenic composition obtainable by said method and a method for immunizing a subject comprising the administration of said immunogenic composition to a subject.
摘要翻译： 本发明涉及一种制备用于治疗和/或预防受试者支原体感染的免疫原性组合物的方法，包括在血清还原或猪血清的真核细胞系统中培养支原体细菌; 获得支原体细菌的抗原; 并加入药学上可接受的载体。 此外，本发明涉及可通过所述方法获得的免疫原性组合物和包括向受试者施用所述免疫原性组合物的受试者的免疫方法。
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公开(公告)号：US20140186394A1
公开(公告)日：2014-07-03
申请号：US14135796
申请日：2013-12-20
申请人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Christine Margaret MUEHLENTHALER , Axel NEUBAUER , Arun V. IYER
发明人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Christine Margaret MUEHLENTHALER , Axel NEUBAUER , Arun V. IYER
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , C12N1/20 , C12N1/36 , C12N5/0686 , C12N2502/70
摘要： The present invention relates to a method for the preparation of an immunogenic composition for the treatment and/or prophylaxis of mycoplasma infections in a subject comprising the cultivation of mycoplasma bacteria in a serum-reduced or swine serum-free, eukaryotic cell system; obtaining an antigen of the mycoplasma bacteria; and addition of a pharmaceutically acceptable carrier. Further, the present invention relates to the immunogenic composition obtainable by said method and a method for immunizing a subject comprising the administration of said immunogenic composition to a subject.
摘要翻译： 本发明涉及一种制备用于治疗和/或预防受试者支原体感染的免疫原性组合物的方法，包括在血清还原或猪血清的真核细胞系统中培养支原体细菌; 获得支原体细菌的抗原; 并加入药学上可接受的载体。 此外，本发明涉及可通过所述方法获得的免疫原性组合物和包括向受试者施用所述免疫原性组合物的受试者的免疫方法。
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公开(公告)号：US09878027B2
公开(公告)日：2018-01-30
申请号：US14135791
申请日：2013-12-20
申请人： Dianna M. Murphy Jordan , Brian Thomas Martinson , Christine Margaret Muehlenthaler , Axel Neubauer , Arun V. Iyer
发明人： Dianna M. Murphy Jordan , Brian Thomas Martinson , Christine Margaret Muehlenthaler , Axel Neubauer , Arun V. Iyer
CPC分类号： A61K39/0241 , A61K35/22 , A61K2039/70
摘要： The present invention relates to an immunogenic composition comprising: a) one or more antigen of M. hyorhinis and one or more antigens of M. hyosynoviae; and b) a pharmaceutically acceptable carrier. Furthermore, the present invention relates to an immunogenic composition that comprises a) one or more mycoplasma antigens of mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae; and b) one or more components of a eukaryotic cell system. Moreover, the present invention also provides an immunogenic composition obtained by a method comprising a) cultivation of a mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae in a serum-reduced, eukaryotic cell system; b) obtaining an antigen of such mycoplasma bacteria; and c) addition of a pharmaceutically acceptable carrier.
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5.发明授权Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use 有权猪繁殖与呼吸综合征病毒，成分，疫苗及使用方法公开(公告)号：US09579373B2
公开(公告)日：2017-02-28
申请号：US14206283
申请日：2014-03-12
申请人： Dianna M. Murphy Jordan , Brian Thomas Martinson , Michael B. Roof , Eric Martin Vaughn , Joseph Gilbert Victoria
发明人： Dianna M. Murphy Jordan , Brian Thomas Martinson , Michael B. Roof , Eric Martin Vaughn , Joseph Gilbert Victoria
IPC分类号： A61K39/12 , C07K14/005 , C07K16/10 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10064
摘要： The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.
摘要翻译： 本发明涉及具有增加的稳定性的猪繁殖与呼吸综合征病毒（PRRSV）突变株; 含有源自其的菌株或抗原的组合物; 含有菌株的疫苗，包括杀死，减毒或亚单位疫苗; 编码PRRSV多肽的核酸，由核酸编码的多肽，包括其抗原性片段; 特异性结合所述多肽的抗体及其制备和使用方法。
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6.发明申请PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, COMPOSITIONS, VACCINE AND METHODS OF USE 有权PORCINE生殖和呼吸道综合症病毒，组合物，疫苗和使用方法公开(公告)号：US20140271698A1
公开(公告)日：2014-09-18
申请号：US14206283
申请日：2014-03-12
申请人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA
发明人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA
IPC分类号： A61K39/12 , C07K14/005 , C07K16/10
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10064
摘要： The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.
摘要翻译： 本发明涉及具有增加的稳定性的猪繁殖与呼吸综合征病毒（PRRSV）突变株; 含有源自其的菌株或抗原的组合物; 含有菌株的疫苗，包括杀死，减毒或亚单位疫苗; 编码PRRSV多肽的核酸，由核酸编码的多肽，包括其抗原性片段; 特异性结合所述多肽的抗体及其制备和使用方法。
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