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    Searching system for biosignature extraction and biomarker discovery
    1.
    发明授权
    Searching system for biosignature extraction and biomarker discovery 有权

    公开(公告)号：US11612322B2

    公开(公告)日：2023-03-28

    申请号：US16753020

    申请日：2018-10-03

    申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

    发明人： Emily Stern ,  David Silbersweig ,  Hong Pan

    IPC分类号： A61B5/00 ,  G16H70/60 ,  G16H15/00 ,  G16H50/30 ,  G16H50/70 ,  G16H50/20 ,  G16H30/40 ,  A61B5/055 ,  A61B5/16 ,  G01R33/48 ,  G01R33/56 ,  G06T7/00

    摘要： An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome. These biosignatures and biomarkers that reveal hidden, implicit, and latent brain circuit patterns provoked by fMRI tasks, can also provide for the development of non-invasive diagnostics and targeted therapeutics in neuropsychiatric diseases.

    SYSTEMS AND METHODS FOR SUTURING TISSUE
    3.
    发明申请
    SYSTEMS AND METHODS FOR SUTURING TISSUE 有权

    公开(公告)号：US20230055633A1

    公开(公告)日：2023-02-23

    申请号：US17878043

    申请日：2022-07-31

    申请人： The Brigham and Women's Hospital, Inc.

    发明人： Jon I. Einarsson ,  Mobolaji Ajao

    IPC分类号： A61B17/04 ,  A61B17/06 ,  A61B17/42 ,  A61B17/062

    摘要： In accordance with an aspect of the present disclosure, an apparatus for suturing tissue is provided that includes a body having a proximate end and a distal end. A suturing head is coupled to the distal end of the body, including a first set of curved needles, a second set of curved needles, and a plurality of sutures. A first end of a suture is coupled to one of the curved needles of the first set. A second end of the suture is coupled to one of the curved needles of the second set. The curved needles of the first set are oppositely oriented to the curved needles of the second set. The suturing head can be positioned between two substantially parallel sections of tissue. An actuator is coupled to the body to deploy the first and second sets of curved needles.

    SYSTEM AND METHOD FOR RESISTANCE-DEPENDENT, SELF-REGULATED MEDICAL PENETRATION
    5.
    发明申请
    SYSTEM AND METHOD FOR RESISTANCE-DEPENDENT, SELF-REGULATED MEDICAL PENETRATION 有权

    公开(公告)号：US20230046514A1

    公开(公告)日：2023-02-16

    申请号：US17851889

    申请日：2022-06-28

    申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

    发明人： Jeffrey Karp ,  Girish Chitnis ,  Julien Lamazouade ,  Mohan K.S. Verma

    IPC分类号： A61M5/315

    摘要： A system for delivering an injection of a fluid into a void within a subject is disclosed. A barrel extends from a first end to a second end and forms a lumen extending from the first end to the second end. A plug and a floating seal are arranged within the lumen. A hollow needle includes a distal end with an opening for fluid to flow from the lumen. The plug, the barrel and the floating seal include material and dimensions selected based on a threshold flowrate for a fluid arranged within the lumen to: overcome a force opposed to a force being applied to the fluid in the lumen to move the floating seal and the hollow needle into a tissue of the subject, and succumb to the opposing force to displace the fluid through the opening into the void.

    RESIDENCE STRUCTURES AND RELATED METHODS
    6.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 有权

    公开(公告)号：US20230039421A1

    公开(公告)日：2023-02-09

    申请号：US17836972

    申请日：2022-06-09

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC分类号： A61K9/00 ,  C08G18/73 ,  C08G63/08 ,  C08G18/42 ,  A61K47/58 ,  A61K47/69 ,  A61K9/48 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  C08G83/00 ,  A61K47/32 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00

    摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

    SYSTEM AND METHOD FOR CONTROLLING PHYSIOLOGICAL NOISE IN FUNCTIONAL MAGNETIC RESONANCE IMAGING
    7.
    发明申请
    SYSTEM AND METHOD FOR CONTROLLING PHYSIOLOGICAL NOISE IN FUNCTIONAL MAGNETIC RESONANCE IMAGING 有权

    公开(公告)号：US20230023393A1

    公开(公告)日：2023-01-26

    申请号：US17788340

    申请日：2020-12-23

    申请人： The Brigham and Women's Hospital, Inc.

    发明人： David SILBERSWEIG ,  Emily STERN ,  Hong PAN ,  Qiang CHEN

    IPC分类号： G01R33/48 ,  G01R33/565

    摘要： A system and method is provided for controlling physiological-noise in functional magnetic resonance imaging using raw k-space data to extract physiological noise effects. The method can identify these effects when they are separable and directly reflects the artefactual effects on fMRI data, without the need for external monitoring or recording devices and to be compensated for via rigorous statistical analysis modeling of such noise sources. The physiological fluctuations may be treated as global perturbations presented around the origin point in a k-space 2D slice. Each k-space 2D slice may be acquired at a very short repetition time with an effective sampling rate to sample cardiac and respiratory rhythms through proper reordering and phase-unwarping techniques applied to the raw k-space data.