公开(公告)号：US08029818B2

公开(公告)日：2011-10-04

申请号：US10157644

申请日：2002-05-29

申请人： Bryan W. Wolf

发明人： Bryan W. Wolf

IPC分类号： A61K9/20 ,  A61K31/70

CPC分类号： A61K31/7004 ,  A23L29/30 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/70 ,  Y10S514/866 ,  A23V2250/606

摘要： The present invention relates to a method for reducing the postprandial glycemic excursion to carbohydrates by feeding supplemental fructose prior to the carbohydrate challenge. The unit does of fructose required to blunt the postprandial glycemic excursion is from about 2 grams to about 30 grams fructose. The fructose source is consumed from about 10 to about 90 minutes before a meal.

摘要翻译： 本发明涉及通过在碳水化合物攻击之前补充果糖来减少餐后血糖偏向于碳水化合物的方法。 单位做果糖所需要的平均餐后血糖偏移约为2克至约30克果糖。 果糖来源在饭前约10至约90分钟消耗。

公开(公告)号：US20080254100A1

公开(公告)日：2008-10-16

申请号：US12133669

申请日：2008-06-05

申请人： Chron-Si Lai ,  JoMay Chow ,  Bryan W. Wolf

发明人： Chron-Si Lai ,  JoMay Chow ,  Bryan W. Wolf

IPC分类号： A61K9/00 ,  A61K31/724 ,  A61P3/10

CPC分类号： A61K31/724 ,  A23L2/02 ,  A23L29/35 ,  A23L33/10 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A23V2250/5112 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2250/54252 ,  A23V2250/61 ,  A23V2250/628 ,  A23V2250/606 ,  A23V2250/708 ,  A23V2250/1644 ,  A23V2250/5488 ,  A23V2250/6406 ,  A23V2250/702 ,  A23V2250/242 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/6416 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/5432 ,  A23V2250/5054 ,  A23V2250/5062 ,  A23V2250/5114

摘要： Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

摘要翻译： 公开了在个体中产生平坦的餐后血糖反应和/或减少餐后胰岛素分泌的方法，所述方法包括向个体施用包含γ-环糊精的营养物或其它产品。 还公开了类似的其它方法，其目的在于使用这些产品提供体重和食欲控制，使葡萄糖耐量降低的个体的血糖水平正常化，以使糖尿病和非糖尿病患者的夜间低血糖最小化，以防止易感性的反应性低血糖 使非糖尿病患者在妊娠期间使妊娠糖尿病患者或葡萄糖耐量降低的血糖水平正常化，和/或在运动期间提供延长的血糖反应。 这些方法是基于发现γ-环糊精在小肠中快速代谢和吸收，但随后导致出乎意料的平坦的餐后血糖反应和胰岛素分泌减少。

公开(公告)号：US06916796B2

公开(公告)日：2005-07-12

申请号：US10167912

申请日：2002-06-12

申请人： Bryan W. Wolf

发明人： Bryan W. Wolf

IPC分类号： A23L2/52 ,  A23L1/054 ,  A23L1/29 ,  A23L1/30 ,  A23L1/307 ,  A61K31/715 ,  A61K31/719 ,  A61P3/10 ,  C08B37/00

CPC分类号： A61K31/715 ,  A23L29/274 ,  A23L33/10 ,  A23L33/20 ,  A23L33/30

摘要： The present invention is directed to the use of pullulan as a slowly digested carbohydrate and to its incorporation into food products, especially beverages and meal replacement products.

摘要翻译： 本发明涉及使用支链淀粉作为缓慢消化的碳水化合物并将其掺入到食品中，特别是饮料和膳食替代产品中。

公开(公告)号：US07423027B2

公开(公告)日：2008-09-09

申请号：US11062243

申请日：2005-02-18

申请人： Chron-Si Lai ,  JoMay Chow ,  Bryan W. Wolf

发明人： Chron-Si Lai ,  JoMay Chow ,  Bryan W. Wolf

IPC分类号： A01N43/04 ,  A61K31/715 ,  C08B37/16

CPC分类号： A61K31/724 ,  A23L2/02 ,  A23L29/35 ,  A23L33/10 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A23V2250/5112 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2250/54252 ,  A23V2250/61 ,  A23V2250/628 ,  A23V2250/606 ,  A23V2250/708 ,  A23V2250/1644 ,  A23V2250/5488 ,  A23V2250/6406 ,  A23V2250/702 ,  A23V2250/242 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/6416 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/5432 ,  A23V2250/5054 ,  A23V2250/5062 ,  A23V2250/5114

摘要： Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

摘要翻译： 公开了在个体中产生平坦的餐后血糖反应和/或减少餐后胰岛素分泌的方法，所述方法包括向个体施用包含γ-环糊精的营养物或其它产品。 还公开了类似的其它方法，其目的在于使用这些产品提供体重和食欲控制，使葡萄糖耐量降低的个体的血糖水平正常化，以使糖尿病和非糖尿病患者的夜间低血糖最小化，以防止易感性的反应性低血糖 使非糖尿病患者在妊娠期间使妊娠糖尿病患者或葡萄糖耐量降低的血糖水平正常化，和/或在运动期间提供延长的血糖反应。 这些方法是基于发现γ-环糊精在小肠中快速代谢和吸收，但随后导致出乎意料的平坦的餐后血糖反应和胰岛素分泌减少。

公开(公告)号：US07422763B2

公开(公告)日：2008-09-09

申请号：US10157296

申请日：2002-05-29

申请人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai

发明人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai

IPC分类号： A61K31/723 ,  A61K31/731 ,  A61K31/732 ,  A61K31/734 ,  A61K31/736 ,  A23L1/0524

CPC分类号： A61K45/06 ,  A23L19/115 ,  A23L29/231 ,  A23L29/238 ,  A23L29/244 ,  A23L29/256 ,  A23L29/262 ,  A23L29/27 ,  A23L29/271 ,  A23L29/272 ,  A23L29/35 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/715 ,  A61K31/718 ,  A61K33/00 ,  A61K36/185 ,  A61K36/286 ,  A61K36/31 ,  A61K36/47 ,  A61K36/48 ,  A61K36/483 ,  A61K36/81 ,  A61K36/888 ,  A61K36/899 ,  Y10S514/866 ,  Y10S514/909 ,  Y10S514/911 ,  A61K2300/00 ,  A23V2250/5114 ,  A23V2250/5026 ,  A23V2250/506 ,  A23V2250/61 ,  A23V2250/5028 ,  A23V2250/51084 ,  A23V2250/16 ,  A23V2250/1578 ,  A23V2250/54252 ,  A23V2250/702 ,  A23V2250/54246 ,  A23V2250/0644 ,  A23V2250/0612 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/1882 ,  A23V2250/211 ,  A23V2250/5424 ,  A23V2250/606 ,  A23V2200/3202 ,  A23V2250/304 ,  A23V2250/264 ,  A23V2250/5118 ,  A23V2200/328 ,  A23V2200/332

摘要： The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding an acid controlled induced viscosity fiber system. The first component of the induced viscosity fiber system is anionic soluble fiber. The second component of the induced viscosity fiber system is water-insoluble, acid-soluble multivalent cations. The fiber system will typically be incorporated into a meal replacement nutritional.The present invention also refers to a method of delivering soluble fiber to diabetics and to persons needing to lose weight. Additionally, the invention refers to a method of promoting the feeling of fullness and satiety by feeding a nutritional product containing the induced viscosity fiber system.

摘要翻译： 本发明一般涉及通过喂食酸控制的诱导粘度纤维系统使餐后血糖反应平缓的方法。 诱导粘度纤维体系的第一个成分是阴离子可溶性纤维。 诱导粘度纤维体系的第二部分是水不溶性，酸溶性多价阳离子。 纤维系统通常将被并入膳食替代营养。 本发明还涉及将可溶性纤维递送到糖尿病患者和需要减肥的人的方法。 此外，本发明涉及通过喂养含有诱导粘度纤维系统的营养产品来促进丰满感和饱腹感的方法。

公开(公告)号：US07183266B2

公开(公告)日：2007-02-27

申请号：US10157298

申请日：2002-05-29

申请人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai ,  Timothy W. Schenz

发明人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai ,  Timothy W. Schenz

IPC分类号： A61K31/715 ,  A61K31/70 ,  A61K47/00

CPC分类号： A61K45/06 ,  A23L19/115 ,  A23L29/231 ,  A23L29/238 ,  A23L29/244 ,  A23L29/256 ,  A23L29/262 ,  A23L29/27 ,  A23L29/271 ,  A23L29/272 ,  A23L29/35 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/715 ,  A61K31/718 ,  A61K33/00 ,  A61K36/185 ,  A61K36/286 ,  A61K36/31 ,  A61K36/47 ,  A61K36/48 ,  A61K36/483 ,  A61K36/81 ,  A61K36/888 ,  A61K36/899 ,  Y10S514/866 ,  Y10S514/909 ,  Y10S514/911 ,  A61K2300/00 ,  A23V2250/5114 ,  A23V2250/5026 ,  A23V2250/506 ,  A23V2250/61 ,  A23V2250/5028 ,  A23V2250/51084 ,  A23V2250/16 ,  A23V2250/1578 ,  A23V2250/54252 ,  A23V2250/702 ,  A23V2250/54246 ,  A23V2250/0644 ,  A23V2250/0612 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/1882 ,  A23V2250/211 ,  A23V2250/5424 ,  A23V2250/606 ,  A23V2200/3202 ,  A23V2250/304 ,  A23V2250/264 ,  A23V2250/5118 ,  A23V2200/328 ,  A23V2200/332

摘要： The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding a dual induced viscosity fiber system. The first component of the induced viscosity fiber system is soluble fiber. The second component of the induced viscosity fiber system is water-insoluble, acid-soluble multivalent cations. The third component of the induced viscosity fiber system in lightly hydrolyzed starch. The fiber system will typically be incorporated into a meal replacement nutritional. The present invention also refers to a method of delivering soluble fiber to diabetics and to persons needing to lose weight. Additionally, the invention refers to a method of promoting the feeling of fullness and satiety by feeding a nutritional product containing the induced viscosity fiber system.

摘要翻译： 本发明总体上涉及一种通过喂食双重诱导粘度纤维系统使餐后血糖反应变平的方法。 诱导粘度纤维体系的第一个成分是可溶性纤维。 诱导粘度纤维体系的第二部分是水不溶性，酸溶性多价阳离子。 轻度水解淀粉中诱导粘度纤维体系的第三部分。 纤维系统通常将被并入膳食替代营养。 本发明还涉及将可溶性纤维递送到糖尿病患者和需要减肥的人的方法。 此外，本发明涉及通过喂养含有诱导粘度纤维系统的营养产品来促进丰满感和饱腹感的方法。

公开(公告)号：US07067498B2

公开(公告)日：2006-06-27

申请号：US10157297

申请日：2002-05-29

申请人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai ,  Timothy W. Schenz

发明人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai ,  Timothy W. Schenz

IPC分类号： A61K31/715 ,  A61K31/70 ,  A61K47/00

CPC分类号： A61K45/06 ,  A23L19/115 ,  A23L29/231 ,  A23L29/238 ,  A23L29/244 ,  A23L29/256 ,  A23L29/262 ,  A23L29/27 ,  A23L29/271 ,  A23L29/272 ,  A23L29/35 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/715 ,  A61K31/718 ,  A61K33/00 ,  A61K36/185 ,  A61K36/286 ,  A61K36/31 ,  A61K36/47 ,  A61K36/48 ,  A61K36/483 ,  A61K36/81 ,  A61K36/888 ,  A61K36/899 ,  Y10S514/866 ,  Y10S514/909 ,  Y10S514/911 ,  A61K2300/00 ,  A23V2250/5114 ,  A23V2250/5026 ,  A23V2250/506 ,  A23V2250/61 ,  A23V2250/5028 ,  A23V2250/51084 ,  A23V2250/16 ,  A23V2250/1578 ,  A23V2250/54252 ,  A23V2250/702 ,  A23V2250/54246 ,  A23V2250/0644 ,  A23V2250/0612 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/1882 ,  A23V2250/211 ,  A23V2250/5424 ,  A23V2250/606 ,  A23V2200/3202 ,  A23V2250/304 ,  A23V2250/264 ,  A23V2250/5118 ,  A23V2200/328 ,  A23V2200/332

摘要： The present invention relates generally to a method of blunting the postprandial glycemic response in a human by feeding an induced viscosity fiber system. The invention also relates to an induced viscosity fiber system and the liquid products that incorporate the induced viscosity fiber system. Further, the invention relates to a method of incorporating soluble fiber into a liquid product without the typical negative organoleptic or physical stability issues. The invention also relates to a method of inducing the feeling of fullness and satiety by feeding the induced viscosity fiber system.

公开(公告)号：US06248375B1

公开(公告)日：2001-06-19

申请号：US09524445

申请日：2000-03-14

申请人： Stephanie M. Gilles ,  Bryan W. Wolf ,  Bradley A. Zinker ,  Keith A. Garleb ,  Joseph E. Walton ,  Sue E. Nicholson

发明人： Stephanie M. Gilles ,  Bryan W. Wolf ,  Bradley A. Zinker ,  Keith A. Garleb ,  Joseph E. Walton ,  Sue E. Nicholson

IPC分类号： A23L1302

CPC分类号： A23L33/21 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23L33/40 ,  Y10S426/80 ,  Y10S426/808 ,  Y10S426/81 ,  Y10S514/866

摘要： The present invention is directed to solid matrix nutritionals designed for the person with diabetes. The carbohydrate system of this invention utilizes a source of fructose in combination with at least one nonabsorbent carbohydrate to achieve the same effect of prior art complex multi-component carbohydrate systems. This carbohydrate system has the added benefits of tasting good and can be incorporated into solid matrix nutritionals. The solid matrix nutritionals may also include a source of dietary fiber and a source of indigestible oligosaccharides. The solid matrix nutritionals may be administered to a diabetic in the form of cereal, bread, cookies, muffins, bagels, biscuits, crackers and bars. Particularly, the present invention is directed to a nutritional bar designed for the person with diabetes which incorporates the carbohydrate system. The present invention is also directed to a method of delivering nutrients to a person with diabetes by feeding the solid matrix nutritionals which incorporates the carbohydrate system.

摘要翻译： 本发明涉及为糖尿病患者设计的固体基质营养物。 本发明的碳水化合物系统利用与至少一种非吸收性碳水化合物结合的果糖来达到现有技术的复合多组分碳水化合物系统的相同效果。 这种碳水化合物系统具有品尝良好的附加益处，可以并入固体基质营养品。 固体基质营养品还可以包括膳食纤维来源和难消化的寡糖来源。 固体基质营养物可以以谷物，面包，饼干，松饼，百吉饼，饼干，饼干和酒吧的形式给予糖尿病。 特别地，本发明涉及一种为糖尿病患者设计的营养棒，其包含碳水化合物系统。 本发明还涉及通过喂养含有碳水化合物系统的固体基质营养物将营养物质递送给糖尿病患者的方法。

公开(公告)号：US08420621B2

公开(公告)日：2013-04-16

申请号：US12133669

申请日：2008-06-05

申请人： Chron-Si Lai ,  JoMay Chow ,  Bryan W. Wolf

发明人： Chron-Si Lai ,  JoMay Chow ,  Bryan W. Wolf

IPC分类号： A01N43/04 ,  A61K31/715

CPC分类号： A61K31/724 ,  A23L2/02 ,  A23L29/35 ,  A23L33/10 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/0095 ,  A23V2250/5112 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2250/54252 ,  A23V2250/61 ,  A23V2250/628 ,  A23V2250/606 ,  A23V2250/708 ,  A23V2250/1644 ,  A23V2250/5488 ,  A23V2250/6406 ,  A23V2250/702 ,  A23V2250/242 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/6416 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/5432 ,  A23V2250/5054 ,  A23V2250/5062 ,  A23V2250/5114

摘要： Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

摘要翻译： 公开了在个体中产生平坦的餐后血糖反应和/或减少餐后胰岛素分泌的方法，所述方法包括向个体施用包含γ-环糊精的营养物或其它产品。 还公开了类似的其它方法，其目的在于使用这些产品提供体重和食欲控制，使葡萄糖耐量降低的个体的血糖水平正常化，以使糖尿病和非糖尿病患者的夜间低血糖最小化，以防止易感性的反应性低血糖 使非糖尿病患者在妊娠期间使妊娠糖尿病患者或葡萄糖耐量降低的血糖水平正常化，和/或在运动期间提供延长的血糖反应。 这些方法是基于发现γ-环糊精在小肠中快速代谢和吸收，但随后导致出乎意料的平坦的餐后血糖反应和胰岛素分泌减少。

公开(公告)号：US07601705B2

公开(公告)日：2009-10-13

申请号：US11391007

申请日：2006-03-28

申请人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai ,  Timothy W. Schenz

发明人： Bryan W. Wolf ,  Bruce B. Blidner ,  Keith A. Garleb ,  Chron-Si Lai ,  Timothy W. Schenz

IPC分类号： A61K31/715 ,  A61K47/00

CPC分类号： A61K45/06 ,  A23L19/115 ,  A23L29/231 ,  A23L29/238 ,  A23L29/244 ,  A23L29/256 ,  A23L29/262 ,  A23L29/27 ,  A23L29/271 ,  A23L29/272 ,  A23L29/35 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/715 ,  A61K31/718 ,  A61K33/00 ,  A61K36/185 ,  A61K36/286 ,  A61K36/31 ,  A61K36/47 ,  A61K36/48 ,  A61K36/483 ,  A61K36/81 ,  A61K36/888 ,  A61K36/899 ,  Y10S514/866 ,  Y10S514/909 ,  Y10S514/911 ,  A61K2300/00 ,  A23V2250/5114 ,  A23V2250/5026 ,  A23V2250/506 ,  A23V2250/61 ,  A23V2250/5028 ,  A23V2250/51084 ,  A23V2250/16 ,  A23V2250/1578 ,  A23V2250/54252 ,  A23V2250/702 ,  A23V2250/54246 ,  A23V2250/0644 ,  A23V2250/0612 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/1882 ,  A23V2250/211 ,  A23V2250/5424 ,  A23V2250/606 ,  A23V2200/3202 ,  A23V2250/304 ,  A23V2250/264 ,  A23V2250/5118 ,  A23V2200/328 ,  A23V2200/332

摘要： The present invention relates generally to a method of blunting the postprandial glycemic response in a human by feeding an induced viscosity fiber system. The invention also relates to an induced viscosity fiber system and the liquid products that incorporate the induced viscosity fiber system. Further, the invention relates to a method of incorporating soluble fiber into a liquid product without the typical negative organoleptic or physical stability issues. The invention also relates to a method of inducing the feeling of fullness and satiety by feeding the induced viscosity fiber system.

摘要翻译： 本发明一般涉及一种通过饲喂诱导粘度纤维系统来消除人类餐后血糖反应的方法。 本发明还涉及诱导粘度纤维系统和结合诱导粘度纤维系统的液体产品。 此外，本发明涉及将可溶性纤维掺入液体产品中而没有典型的负面感官或物理稳定性问题的方法。 本发明还涉及通过喂入诱导粘度纤维系统诱导丰满感和饱腹感的方法。