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1.发明授权Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides 有权编码通过自切割肽连接的重编程因子的核酸构建体公开(公告)号：US09497943B2
公开(公告)日：2016-11-22
申请号：US12997815
申请日：2009-06-15
IPC分类号： C12N15/00 , A01K67/027 , C12N5/074 , G01N33/50 , C12N15/86 , C12N15/85 , C12N5/0735 , C12N15/79
CPC分类号： C12N15/86 , A01K67/0271 , C07K14/4705 , C12N5/0606 , C12N5/0696 , C12N15/79 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/11 , C12N2506/115 , C12N2510/00 , C12N2740/15041 , C12N2740/15043 , C12N2740/16043 , C12N2799/027 , C12N2800/108 , C12N2840/203 , G01N33/5008
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在进一步的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞细胞，包含本发明的重编程体细胞的嵌合动物，所述细胞的用途以及用于鉴定用于重编程体细胞的药物的方法。
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公开(公告)号：US20120028821A1
公开(公告)日：2012-02-02
申请号：US12997815
申请日：2009-06-15
CPC分类号： C12N15/86 , A01K67/0271 , C07K14/4705 , C12N5/0606 , C12N5/0696 , C12N15/79 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/11 , C12N2506/115 , C12N2510/00 , C12N2740/15041 , C12N2740/15043 , C12N2740/16043 , C12N2799/027 , C12N2800/108 , C12N2840/203 , G01N33/5008
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在进一步的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞细胞，包含本发明的重编程体细胞的嵌合动物，所述细胞的用途以及用于鉴定用于重编程体细胞的药物的方法。
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