-
公开(公告)号：US09057701B2
公开(公告)日：2015-06-16
申请号：US12817422
申请日：2010-06-17
申请人： Peter Ramm , Yuriy Alexandrov , Paul Donders , Carlos Zarate , Bohdan J. Soltys
发明人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan J. Soltys
CPC分类号： G01N21/6458 , G01N15/1475 , G01N21/6428 , G01N33/5026 , G01N2015/1497 , G01N2333/4603 , G06K9/00127 , G06T7/0012 , G06T7/187 , G06T2207/10056 , G06T2207/30024
摘要： A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.
摘要翻译： 用于在药物发现中进行自动细胞筛选的系统包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。
-
公开(公告)号：US20130129212A1
公开(公告)日：2013-05-23
申请号：US13813197
申请日：2011-07-19
申请人： Pavel A. Fomitchov , Witold Bula , Carlos Zarate , Yang Zhang
发明人： Pavel A. Fomitchov , Witold Bula , Carlos Zarate , Yang Zhang
IPC分类号： G06T5/00
摘要： The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.
摘要翻译： 本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。 用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。 优选地，该方法还包括校正随机列偏移和增益。 可选地，该方法还包括限制缺陷像素和/或减去暗电流。 当单色图像是荧光图像时，该方法还包括压缩CMOS相机噪声的步骤。 还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统，以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。
-
公开(公告)号：US20090074283A1
公开(公告)日：2009-03-19
申请号：US12253275
申请日：2008-10-17
申请人： PETER RAMM , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan J. Soltys
发明人： PETER RAMM , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan J. Soltys
IPC分类号： G06K9/00
CPC分类号： G01N21/6458 , G01N15/1475 , G01N21/6428 , G01N33/5026 , G01N2015/1497 , G01N2333/4603 , G06K9/00127 , G06T7/0012 , G06T7/187 , G06T2207/10056 , G06T2207/30024
摘要： A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.
摘要翻译： 用于在药物发现中进行自动细胞筛选的系统包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最少的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。
-
公开(公告)号：US07335898B2
公开(公告)日：2008-02-26
申请号：US11184444
申请日：2005-07-19
申请人： Paul Donders , Carlos Zarate , Pavel A. Fomitchov
发明人： Paul Donders , Carlos Zarate , Pavel A. Fomitchov
IPC分类号： G01N21/64
CPC分类号： G02B21/0076 , G02B21/0036 , G02B21/0064 , G02B21/0084
摘要： A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.
摘要翻译： 提出了一种新的改进的共焦荧光显微镜。 新显微镜相对于现有的显微镜共焦成像仪的实现具有显着的优势。 与以前的共焦成像仪相同，本发明相对于传统的宽场和共聚焦荧光成像器具有优点，但是它在成本和复杂性方面解决了共聚焦技术的缺点，并且由于简化了 组件和消除特别是诸如针孔或狭缝的空间滤波器的需要。
-
公开(公告)号：US20070287753A1
公开(公告)日：2007-12-13
申请号：US11688603
申请日：2007-03-20
申请人： Dennis Charney , Sanjay Mathew , Husseini Manji , Carlos Zarate , John Krystal
发明人： Dennis Charney , Sanjay Mathew , Husseini Manji , Carlos Zarate , John Krystal
CPC分类号： A61K31/135 , A61K9/0019 , A61K9/0043 , A61K9/008 , A61K9/12 , A61K9/7023 , A61K31/137 , A61K45/06 , A61M15/0068 , A61M15/08
摘要： Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).
摘要翻译： 描述了治疗耐药性抑郁症的方法和组合物。 更具体地说，本发明表明，氯胺酮的鼻内给药有效地改善了在目前发作中没有对一种抗抑郁药的适当试验作出反应并且具有复发或慢性抑郁症状（> 2年）的患者的抑郁症状。
-
公开(公告)号：US20060257013A1
公开(公告)日：2006-11-16
申请号：US10514925
申请日：2003-05-09
申请人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan Soltys
发明人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan Soltys
IPC分类号： G06K9/00
CPC分类号： G01N21/6458 , G01N15/1475 , G01N21/6428 , G01N33/5026 , G01N2015/1497 , G01N2333/4603 , G06K9/00127 , G06T7/0012 , G06T7/187 , G06T2207/10056 , G06T2207/30024
摘要： A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.
摘要翻译： 一种用于在药物发现中进行自动细胞筛选的系统，包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。
-
公开(公告)号：US5305083A
公开(公告)日：1994-04-19
申请号：US598560
申请日：1990-10-16
CPC分类号： G01J3/02 , G01J3/0232 , G01J3/0256 , G01J3/12 , G01J2003/1278 , G01J2003/1286 , G01N2201/067
摘要： A random access monochromator is disclosed. This device has no mechanical parts and eliminates the need to scan sequentially the wavelengths of light contained in a light spectrum to select a desired wavelength or wavelengths from the spectrum. The device has high speed switching means, permits one to select multiple wavelengths and bandwidths at the same time, and has the ability to correct for non-linearity in prisms caused by their nonlinear or second order dispersion of light.
摘要翻译： 公开了一种随机存取单色仪。 该装置没有机械部件，并且不需要依次扫描包含在光谱中的光的波长以从光谱中选择期望的波长或波长。 该装置具有高速切换装置，允许同时选择多个波长和带宽，并且具有校正由其非线性或二阶色散引起的棱镜中的非线性的能力。
-
8.发明授权公开(公告)号：US08253263B2
公开(公告)日：2012-08-28
申请号：US12430042
申请日：2009-04-24
申请人： Alvaro Atilano , Carlos Zarate , Jaime Zarate , Mario Favaretto , Felix Tovar , Rafael Uzcategui
发明人： Alvaro Atilano , Carlos Zarate , Jaime Zarate , Mario Favaretto , Felix Tovar , Rafael Uzcategui
IPC分类号： F03B13/12
CPC分类号： F03B13/186 , F05B2260/4031 , F05B2260/503 , Y02E10/38
摘要： A wave energy conversion system or device includes a float and base on top of which there is a power take-off system. The float, its base and the machine room are inserted in a main column supported by legs and corresponding leg supports on the bottom floor in shallow waters (seas or lakes). In deeper waters, the main column may be supported by column supports attached to an underwater float. The machine room is separated of the float frame through a rotary joint which allows the float and base to rotate in any horizontal direction while maintaining the machine room fixed in the same horizontal direction. The rotary joint separating the float frame and the machine room also allows for the vertical up and down movement when interacting with incoming waves. The distance between the machine room and the float frame is always the same. The device includes flaps or blades for the absorption of kinetic energy derived from the back and forth movement of water generated by waves. The device extracts potential energy of the wave from the up and down movement of the floating structure through a power take-off system in the machine room.
摘要翻译： 波能量转换系统或装置包括浮子和底座，其上有动力输出系统。 浮子，底座和机房插入一个主支柱，支撑在浅水区域（海洋或湖泊）底部底部的支腿和相应的支脚。 在较深的水域，主柱可以由连接在水下浮标上的柱支撑支撑。 机房通过旋转接头与浮子框架分开，允许浮子和底座在任何水平方向上旋转，同时将机房固定在相同的水平方向。 分离浮框和机房的旋转接头还允许在与入波相互作用时的垂直上下移动。 机房与浮框之间的距离总是相同的。 该装置包括用于吸收由波浪产生的水的前后运动产生的动能的襟翼或叶片。 该装置通过机房中的动力输出系统从浮动结构的上下运动中提取波的势能。
-
公开(公告)号：US07764822B2
公开(公告)日：2010-07-27
申请号：US12253275
申请日：2008-10-17
申请人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan Soltys
发明人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan Soltys
IPC分类号： G06K9/00
CPC分类号： G01N21/6458 , G01N15/1475 , G01N21/6428 , G01N33/5026 , G01N2015/1497 , G01N2333/4603 , G06K9/00127 , G06T7/0012 , G06T7/187 , G06T2207/10056 , G06T2207/30024
摘要： A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.
摘要翻译： 用于在药物发现中进行自动细胞筛选的系统包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。
-
公开(公告)号：US07469056B2
公开(公告)日：2008-12-23
申请号：US10514925
申请日：2003-05-09
申请人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan J. Soltys
发明人： Peter Ramm , Yuriy Alexandrov , Jurich Cybuch , Paul Donders , Carlos Zarate , Bohdan J. Soltys
IPC分类号： G06K9/00
CPC分类号： G01N21/6458 , G01N15/1475 , G01N21/6428 , G01N33/5026 , G01N2015/1497 , G01N2333/4603 , G06K9/00127 , G06T7/0012 , G06T7/187 , G06T2207/10056 , G06T2207/30024
摘要： A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.
摘要翻译： 一种用于在药物发现中进行自动细胞筛选的系统，包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.026 秒)
