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公开(公告)号：US11782051B2
公开(公告)日：2023-10-10
申请号：US16995734
申请日：2020-08-17
Applicant: CFD Research Corporation
Inventor： Balabhaskar Prabhakarpandian , Kapil Pant , Kevin Daniel Roehm , Ketan Harendrakumar Bhatt
CPC classification number: G01N33/5029 , G01N33/5005 , G01N33/5011 , G01N33/5061 , G01N33/5088 , G01N33/86 , B01L3/5027 , G01N2333/4703 , G01N2333/70525
Abstract: A method of creating a reperfusion injury can include: providing a cell culture device having an internal chamber with at least one port coupled to a perfusion modulating system capable of modulating perfusion in the internal chamber, wherein the internal chamber includes a cell culture; perfusing a fluid through the internal chamber with the perfusion modulating system, wherein the perfusion modulating system includes at least one pump; reducing fluid flow through the internal chamber; reperfusing fluid flow through the internal chamber; and creating a reperfusion injury in the cell culture by the reperfusion of the fluid flow through the internal chamber. The cell culture includes at least one type of tissue cell. The cell culture can include a tissue construct formed of hydrogel and/or extracellular matrix.
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公开(公告)号：US20240377386A1
公开(公告)日：2024-11-14
申请号：US18659540
申请日：2024-05-09
Applicant: CFD Research Corporation
Abstract: A diagnostic system is provided, which can include a sample tube having an input end and an output end, a microfluidic device, a heating member, and a reagent. The microfluidic device may include a port member configured to couple with the sample tube, a sample distribution member coupled with the port member and having a microfluidic network with microfluidic channels, reaction chambers fluidly coupled with the microfluidic channels, a top cover configured to receive the sample tube therein and having openings corresponding to the reaction chambers, and a bottom member configured to mate with the top cover to enclose the port member and the sample distribution member. The bottom member may include a bottom chamber for retaining a composition. The heating member may be placed in the bottom chamber, and the reagent in the reaction chambers may provide a colorimetric reading upon interaction with a target analyte in the sample.
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公开(公告)号：US20200378952A1
公开(公告)日：2020-12-03
申请号：US16995734
申请日：2020-08-17
Applicant: CFD Research Corporation
Inventor： Balabhaskar Prabhakarpandian , Kapil Pant , Kevin Daniel Roehm , Ketan Harendrakumar Bhatt
Abstract: A method of creating a reperfusion injury can include: providing a cell culture device having an internal chamber with at least one port coupled to a perfusion modulating system capable of modulating perfusion in the internal chamber, wherein the internal chamber includes a cell culture; perfusing a fluid through the internal chamber with the perfusion modulating system, wherein the perfusion modulating system includes at least one pump; reducing fluid flow through the internal chamber; reperfusing fluid flow through the internal chamber; and creating a reperfusion injury in the cell culture by the reperfusion of the fluid flow through the internal chamber. The cell culture includes at least one type of tissue cell. The cell culture can include a tissue construct formed of hydrogel and/or extracellular matrix.
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公开(公告)号：US20210269868A1
公开(公告)日：2021-09-02
申请号：US17187267
申请日：2021-02-26
Applicant: CFD Research Corporation
IPC: C12Q1/6853 , C12Q1/6832 , C12Q1/6816
Abstract: A primer composition for amplifying a target nucleic acid of a plurality of target organisms can include: a first primer having in order: 3′-a first target specific sequence; a melt key region; and a first super primer region, wherein the first target specific sequence includes a nucleic acid sequence that specifically hybridizes with a first unique nucleic acid sequence of a first target organism over nucleic acid sequences of other organisms, the melt key region includes a nucleic acid sequence that has less than full identity with a melt key probe and a complement of the melt key region hybridizes with the melt key probe with at least one nucleotide mismatch with the melt key probe, and the first super primer region includes a nucleic acid sequence that is common to the plurality of target organisms.
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公开(公告)号：US20210116338A1
公开(公告)日：2021-04-22
申请号：US17074007
申请日：2020-10-19
Applicant: CFD RESEARCH CORPORATION
Abstract: A fluidic device can include: a plurality of fluid conduits, each fluid conduit including a first conduit portion separated from a second conduit portion; and at least one transport body that is movably positioned between the first conduit portion and the second conduit portion of each fluid conduit. The at least one transport body can include: at least one port adapted to be aligned with a first conduit portion and a second conduit portion of at least one first conduit so as to fluidly couple the first conduit portion with the second conduit portion; and at least one blocking body portion adapted to be aligned with a first conduit portion and a second conduit portion of at least one second conduit so as to fluidly isolate the first conduit portion from the second conduit portion of the at least one second conduit.
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Patent Agency Ranking
公开(公告)号：US20240197166A1
公开(公告)日：2024-06-20
申请号：US18542002
申请日：2023-12-15
Applicant: CFD Research Corporation
CPC classification number: A61B3/0025 , G06T7/0012 , G06T15/00 , G16H50/20 , G16H50/50 , G06T2207/30024 , G06T2207/30041
Abstract: The method involves computationally modeling a cornea by simulating physical cornea models with computational in silico models. The simulated data is compared with actual data from the physical models, and the simulation is iterated until a match is achieved. The method may also include calibrating diffusion parameters for testing substances, and configuring the models for analyzing instances of fluid-induced shear and substance transport. The simulated data may be used to obtain corneal pharmacokinetic models, and the method may be used to obtain predictions for time-dependent concentrations of molecules in the eye or systemic circulation. The computational models may consider instances of convective-diffusive transport and carrier-mediated transport in calculations and determinations of transport characteristics and values of different testing substances.
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公开(公告)号：US20240161653A1
公开(公告)日：2024-05-16
申请号：US18511347
申请日：2023-11-16
Applicant: CFD Research Corporation
Inventor： Carrie Lynn German , Balabhaskar Prabhakarpandian , Ketan Harendrakumar Bhatt , Ashley Gilbert Helser
IPC: G09B23/28
CPC classification number: G09B23/281
Abstract: The method involves computationally modeling a placenta by simulating physical placenta models with computational in silico models. The simulated data is compared with actual data from the physical models, and the simulation is iterated until a match is achieved. The method may also include calibrating diffusion parameters for testing substances, and configuring the models for analyzing instances of fluid-induced shear and substance transport. The simulated data may be used to obtain maternal-fetal pharmacokinetic in silico placenta models, and the method may be used to obtain predictions for time-dependent concentrations of molecules in fetal circulation. The computational models may consider instances of fluid-diffusive transport and carrier-mediated transport in calculations and determinations of transport characteristics and values of different testing substances.
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公开(公告)号：US20210346584A1
公开(公告)日：2021-11-11
申请号：US17313830
申请日：2021-05-06
Applicant: CFD Research Corporation
Abstract: A portable platelet apheresis system can include: a whole blood inlet configured to receive whole blood; an anticoagulant source containing an anticoagulant; a mixer fluidly coupled with the whole blood inlet and anticoagulant source and configured to mix the whole blood and the anticoagulant; a whole blood sorter microfluidic network; a platelet poor outlet positioned to receive a platelet poor fraction; and a platelet concentrator outlet positioned to receive a concentrated platelet fraction. The whole blood sorter microfluidic network includes: a sorter constricted region having a first cross-sectional dimension; a sorter expansion region having a second cross-sectional dimension that is larger than the first cross-sectional dimension; at least one sorter side channel (platelet rich plasma channel) formed into a side of the sorter expansion region; and at least one sorter outlet (platelet poor plasma channel) that is downstream or medial from the at least one sorter side channel.
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公开(公告)号：US20250161939A1
公开(公告)日：2025-05-22
申请号：US18952740
申请日：2024-11-19
Applicant: CFD Research Corporation
IPC: B01L3/00
Abstract: A system for analyzing a sample can include a sample tube with an input end having a removable lid and an output end, and a microfluidic device. The microfluidic device may include a port member configured to couple with the output end; a sample distribution member coupled with the port member and having a microfluidic network with microfluidic channels; reaction chambers fluidly coupled with the microfluidic channels; and a reactor member configured to generate and display light signals on a display, the light signals generated based on reactions in the reaction chambers and indicating results of the reactions.
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公开(公告)号：US20240203290A1
公开(公告)日：2024-06-20
申请号：US18541346
申请日：2023-12-15
Applicant: CFD Research Corporation
IPC: G09B23/30
CPC classification number: G09B23/303
Abstract: A microfluidic in vitro cornea device is provided, which can include a tear flow chamber, stromal chamber, endothelial chamber, and aqueous humor chamber. The stromal chamber is adjacent to and porously coupled with the tear flow chamber. The endothelial chamber is adjacent to and porously coupled with the stromal chamber. The aqueous humor chamber adjacent to and porously coupled with the endothelial chamber. A first porous wall is positioned between the tear flow chamber and the stromal chamber. A second porous wall is positioned between the stromal chamber and the endothelial chamber. The third porous wall is positioned between the endothelial chamber and the aqueous humor chamber. The device is configured as a microfluidic in vitro model of a cornea.
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