公开(公告)号：US20220305042A1

公开(公告)日：2022-09-29

申请号：US17839851

申请日：2022-06-14

申请人： The Brigham and Women`s Hospital, Inc. ,  The City University of New York, represented by The Research Foundation of the City University of NY

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  George John ,  Greg Cruikshank

IPC分类号： A61K31/7034 ,  A61K9/06 ,  A61K31/167 ,  A61K45/06 ,  A61K31/12 ,  A61K31/555 ,  A61K31/22 ,  A61K31/405 ,  A61K31/43 ,  A61K47/55 ,  A61K47/54

摘要： This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.

公开(公告)号：US11447569B2

公开(公告)日：2022-09-20

申请号：US15555808

申请日：2016-03-07

申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY ,  PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY ,  PHARMA FOODS INTERNATIONAL CO., LTD.

发明人： Mamoru Sato ,  Michiyuki Yamada ,  Satoshi Kanazawa ,  Masayoshi Toyoura ,  Yuji Shoya ,  Kenji Saito ,  Chihiro Yamazaki

IPC分类号： A61K39/395 ,  C07K16/40 ,  C12N15/63 ,  C12N9/99 ,  C12N15/09 ,  A61K39/00

摘要： Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0×10−9 or less. Optionally, the anti-PAD4 antibody and a TNFα inhibitor are used in combination.

公开(公告)号：US20170035891A1

公开(公告)日：2017-02-09

申请号：US15213055

申请日：2016-07-18

申请人： The Brigham and Women's Hospital, Inc. ,  The City University of New York, represented by The Research Foundation of the City University of

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  George John ,  Greg Cruikshank

IPC分类号： A61K47/48 ,  A61K31/167 ,  A61K45/06 ,  A61K9/06

CPC分类号： A61K47/48038 ,  A61K9/06 ,  A61K31/12 ,  A61K31/167 ,  A61K31/22 ,  A61K31/405 ,  A61K31/43 ,  A61K31/555 ,  A61K31/7034 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/55 ,  A61K47/555 ,  A61K2300/00

摘要： This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.

摘要翻译： 本发明公开了药物递送组合物，制备前药的方法以及使用自组装凝胶剂的药物递送方法。 凝胶剂的骨架可以含有药物或前药，如对乙酰氨基酚或水杨苷。 另外的药物或药剂可以包封在凝胶剂中。 酶或水解裂解可用于释放药物。

公开(公告)号：US20180044434A1

公开(公告)日：2018-02-15

申请号：US15555808

申请日：2016-03-07

申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY ,  PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY ,  PHARMA FOODS INTERNATIONAL CO., LTD.

发明人： Mamoru SATO ,  Michiyuki YAMADA ,  Satoshi KANAZAWA ,  Masayoshi TOYOURA ,  Yuji SHOYA ,  Kenji SAITO ,  Chihiro YAMAZAKI

IPC分类号： C07K16/40

CPC分类号： C07K16/40 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/99 ,  C12N15/09 ,  C12Y305/03015 ,  A61K2300/00

摘要： Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0×10−9 or less. Optionally, the anti-PAD4 antibody and a TNFα inhibitor are used in combination.

公开(公告)号：US11458153B2

公开(公告)日：2022-10-04

申请号：US15213055

申请日：2016-07-18

申请人： The Brigham and Women's Hospital, Inc. ,  The City University of New York, represented by The Research Foundation of the City University of New York

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  George John ,  Greg Cruikshank

IPC分类号： A61K47/48 ,  A61K31/7034 ,  A61K9/06 ,  A61K31/167 ,  A61K45/06 ,  A61K31/12 ,  A61K31/555 ,  A61K31/22 ,  A61K31/405 ,  A61K31/43 ,  A61K47/55 ,  A61K47/54

摘要： This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.

公开(公告)号：US20230127342A1

公开(公告)日：2023-04-27

申请号：US17510369

申请日：2021-10-25

申请人： City University of Hong Kong

发明人： Martin GARAJ ,  Shu Hung Henry CHUNG

IPC分类号： H04Q11/00 ,  H04B10/524 ,  H04B10/69 ,  H04B10/11

摘要： The present invention provides an apparatus for facilitating a photovoltaic device to provide a wireless communication channel. The apparatus comprises a switch connected in parallel with the photovoltaic device and configured for driving the photovoltaic device to produce optical signals carrying sensed data to be transmitted; and a control module connected with the switch and configured for receiving electrical sensing signals and generate a control signal to control the switch. The apparatus provided by the present invention is extremely durable. Compared to existing communication technologies which require extra hardware, the apparatus provided by the present invention is simpler and can be integrated into a single component.

公开(公告)号：US20230118359A1

公开(公告)日：2023-04-20

申请号：US17502031

申请日：2021-10-14

申请人： City University of Hong Kong

发明人： Tianjiao WANG ,  Zengfu WANG ,  Moshe ZUKERMAN ,  Bill MORAN

IPC分类号： H04L12/24 ,  H04L12/44 ,  H04L12/721

摘要： The present invention provides a cable network planning method comprising: modelling the prespecified topology as a Steiner tree including a plurality of terminal nodes representing a plurality of cable landing stations (CLSs) to be installed respectively in a plurality of destination regions connected by the cable network, a plurality of Steiner nodes presenting a plurality of branching units (BUs) to be installed in the cable network, and a plurality of edges connecting the terminal nodes and Steiner nodes; constructing a directed acyclic graph (DAG); finding a Steiner minimal tree (SMT) by applying a DAG-Least-Cost-System algorithm; returning coordinates of Steiner nodes, terminal nodes of the SMT as locations of the BUs and the CLSs. The provided method enables inclusion of costs of the Steiner nodes by taking account of Steiner nodes with degree in excess of three such that more flexible BU branching structures and CLS locations alternatives can be considered.

公开(公告)号：US20230115347A1

公开(公告)日：2023-04-13

申请号：US17500934

申请日：2021-10-13

申请人： City University of Hong Kong

发明人： Jian LU ,  Guo LIU

IPC分类号： B29C64/135 ,  B33Y80/00 ,  B33Y10/00

摘要： The present invention provides a method of in situ 4D printing of high-temperature materials including 3D printing a structure of an ink including a precursor. The structure is treated with controlled high energy flow to create a portion which has a different coefficient of thermal expansion/thermal shrinkage ratio. The structure is heated and the difference in the coefficient of thermal expansion creates an interface stress to cause a selected level of deformation. Alternatively, two structures with different coefficients of expansion/thermal shrinkage ratio may be printed. Thermal treatment of the two structures creates an interface stress to cause a selected level of deformation.

公开(公告)号：US11627473B2

公开(公告)日：2023-04-11

申请号：US17367453

申请日：2021-07-05

申请人： City University of Hong Kong

发明人： Miaomiao Dong ,  Jingjin Timothy Wu ,  Wing-Ming Eric Wong

IPC分类号： H04W16/18 ,  H04W28/16 ,  H04W88/08

摘要： A method for determining a layout of a wireless communication network is provided in the present invention. Numerous realizations of user device placement in a considered geometry are measured to reflect the practical distribution of the user devices in a more accurate way than the conventional approach which emulates the randomness of placements of user devices using a tractable stochastic process. Moreover, a scenario sampling approach is used to provide a lower-complexity and higher efficient way to yield optimal base station deployment results while guaranteeing the quality of service of a specified majority of the overall user device realizations.

公开(公告)号：US20230102090A1

公开(公告)日：2023-03-30

申请号：US17482413

申请日：2021-09-22

申请人： City University of Hong Kong

发明人： Abdelrahman Bakr Mohammed Abdelnaby ELDALY ,  Mehdi Hasan CHOWDHURY ,  Stephen Kugbere AGADAGBA ,  Ray Chak Chung CHEUNG ,  Leanne Lai Hang CHAN

IPC分类号： A61B5/00 ,  A61B5/374

摘要： The present invention provides a system for implementing a logistic regression classification mechanism to measure and assess a depth of anesthesia of an animal subject based on electroencephalography (EEG), which includes a signal pre-processor, an epoch generator, a feature extractor, a classifier, and a predictor. Related method of how to pre-process the raw data of EEG signal, epoch generation thereof, feature extraction from each epoch, classification based on extracted features, and prediction of different states of the animal subject based on a prediction decision mechanism is also provided. Classification accuracy of the present invention for 1-second and 10% overlapping epochs is about 94% with an average total system delay of about 12 μs and low on-chip power consumption. The present system is entirely optimized, which leads to a 100% accurate channel prediction after a 7-second run-time on average.