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公开(公告)号：US4342767A
公开(公告)日：1982-08-03
申请号：US159983
申请日：1980-06-16
IPC分类号： C07D309/30 , C12P7/62 , C12P17/06 , A61K31/22 , C07C69/74
CPC分类号： C07D309/30 , C12P17/06 , C12P7/62
摘要： Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
摘要翻译： 在培养基中培养属于曲霉属的微生物后分离的物质包括具有以下结构的化合物：II与羧酸的盐和酯一起形成一类高活性的低胆固醇和 降血药
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公开(公告)号：US4294926A
公开(公告)日：1981-10-13
申请号：US114458
申请日：1980-01-23
IPC分类号： C07D309/30 , C12P7/62 , C12P17/06 , C12P7/26
CPC分类号： C12P7/62 , C07D309/30 , C12P17/06 , Y10S435/913
摘要： Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
摘要翻译： 在培养基中培养属于曲霉属的微生物后分离的物质包含称为MSD803的化合物，其具有内酯结构：其游离羟基酸形式。 与游离酸形式的盐和酯一起，这些化合物形成一类高活性的低胆固醇和降血脂药物。
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公开(公告)号：US4231938A
公开(公告)日：1980-11-04
申请号：US48946
申请日：1979-06-15
IPC分类号： A61K31/19 , A61K31/22 , A61K31/35 , A61K31/351 , A61K31/365 , A61P3/06 , C07C69/24 , C07C69/30 , C07C69/34 , C07D309/30 , C12P7/40 , C12P7/42 , C12P7/62 , C12P17/06 , C12R1/66
CPC分类号： C07D309/30 , C12P17/06 , C12P7/62
摘要： Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
摘要翻译： 在培养基中培养属于曲霉属的微生物后分离的物质包含称为MSD803的化合物，其具有内酯结构：其游离羟基酸形式。 与游离酸形式的盐和酯一起，这些化合物形成一类高活性的低胆固醇和降血脂药物。
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公开(公告)号：US3963691A
公开(公告)日：1976-06-15
申请号：US512563
申请日：1974-10-07
CPC分类号： C07K5/0821 , C07K5/1005 , C07K7/23 , A61K39/00 , Y10S514/80 , Y10S530/812 , Y10S530/815 , Y10S930/13 , Y10S930/28
摘要： Synthetic antigens related to luteinizing hormone-releasing hormone (hereinafter designated LH-RH) having the amino acid composition, pyroglutamyl-histidyl-tryptophanylseryl-tyrosyl-glycyl-leucyl-arginyl-prolyl-glycyl-poly-L-lysine (hereinafter designated pyroglu-his-trp-ser-tyr-glyleu-arg-pro-gly-poly-L-lys) and poly-L-lysyl-glutarylhistidyl-tryptophanyl-seryl-tyrosyl-glycyl-leucyl-arginylprolyl-glycine amide (hereinafter designated poly-L-lysglutaryl-his-trp-ser-tyr-gly-leu-arg-pro-gly) are prepared by coupling the corresponding decapeptide with poly-L-lysine. The corresponding decapeptides are prepared by controlled stepwise procedures starting with individual amino acid components. These antigens have the property of inducing formation of antibodies to luteinizing hormone-releasing hormone (LH-RH) in animals.
摘要翻译： 与具有氨基酸组成的促黄体激素释放激素（以下称为LH-RH）相关的合成抗原，焦谷氨酰 - 组氨酰基 - 色氨酰基 - 酰基 - 酪氨酰 - 甘氨酰 - 亮氨酰 - 精氨酰 - 脯氨酰 - 甘氨酰 - 聚-L-赖氨酸（以下称为pyroglu- his-trp-ser-tyr-glyleu-arg-pro-gly-poly-L-lys）和聚-L-赖氨酰 - 戊二酰基组氨酰基 - 色氨酸 - 丝氨酰 - 酪氨酰 - 甘氨酰 - 亮氨酰 - 炔丙基 - 甘氨酰胺（下文称为聚 - 通过将相应的十肽与聚-L-赖氨酸偶联来制备L-赖氨酰赖氨基-he-trp-ser-tyr-gly-leu-arg-pro-gly）。 相应的十肽通过从各个氨基酸组分开始的受控逐步方法制备。 这些抗原具有在动物体内诱导形成促黄体激素释放激素（LH-RH）的抗体的性质。
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