公开(公告)号：US3959305A

公开(公告)日：1976-05-25

申请号：US504962

申请日：1974-09-11

申请人： Anthony Trevor Ainsworth ,  Carl John Rose

发明人： Anthony Trevor Ainsworth ,  Carl John Rose

IPC分类号： C07D233/90 ,  C07D233/92

CPC分类号： C07D233/90

摘要： Compounds of the formula (II): ##SPC1##wherein R.sub.1 is an aliphatic moiety of 1-12 carbon atoms, a cycloaliphatic moiety of 3-7 carbon atoms or said aliphatic moiety or said cycloaliphatic moiety substituted by halogen, carboxylic acid, esterified carboxylic acid, carboxamide, nitro, hydroxyl, etherified hydroxyl, acylated hydroxyl, amino, alkylamino, dialkylamino or acylated amino: R.sub.2 is a hydrocarbon of 1-7 carbon atoms: R.sub.3 is amino, lower alkylamino, di-lower alkylamino, anilino or lower alkoxyl; R.sub.4 is hydrogen, R.sub.5 or CO.R.sub.5 wherein R.sub.5 is a hydrocarbon of 1-7 carbon atoms, are useful for their anti-inflammatory activity.

摘要翻译： 式（II）的化合物：

公开(公告)号：US4062978A

公开(公告)日：1977-12-13

申请号：US588638

申请日：1975-06-20

申请人： William Gwyn Cole ,  Alexander Crossan Goudie ,  Carl John Rose

发明人： William Gwyn Cole ,  Alexander Crossan Goudie ,  Carl John Rose

IPC分类号： A61K31/12 ,  A61K31/13 ,  C07C29/143 ,  C07C45/45 ,  C07C45/46 ,  C07C45/62 ,  C07C45/64 ,  C07C45/71 ,  C07C49/213 ,  C07C49/215 ,  C07C49/217 ,  C07C49/223 ,  C07C49/225 ,  C07C49/235 ,  C07C49/245 ,  C07C49/248 ,  C07C49/255 ,  C07C49/76 ,  C07C49/782 ,  C07C49/792 ,  C07C49/794 ,  C07C49/813 ,  C07C49/83 ,  C07C49/84 ,  A01N9/24

CPC分类号： C07C49/84 ,  C07C205/45 ,  C07C29/143 ,  C07C45/45 ,  C07C45/46 ,  C07C45/62 ,  C07C45/64 ,  C07C45/71 ,  C07C49/213 ,  C07C49/215 ,  C07C49/217 ,  C07C49/223 ,  C07C49/225 ,  C07C49/235 ,  C07C49/245 ,  C07C49/248 ,  C07C49/255 ,  C07C49/76 ,  C07C49/782 ,  C07C49/792 ,  C07C49/794 ,  C07C49/813 ,  C07C49/83

摘要： Anti-inflammatory compositions are prepared which comprise a therapeutically effective amount of a compound of the formula ##STR1## wherein X is CO or CHOH; Y is CO, an oxygen atom or a direct bond; the dotted line represents a double bond which is optionally present when Y is an oxygen atom or a direct bond; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl, acetoxyl, nitro or amino; R.sub.3 is alkyl of 3-8 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 3-8 carbon atoms, cycloalkenyl of 5-8 carbon atoms, phenyl or phenyl substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloxyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino.Compounds of the above formula are novel except that R.sub.1 must be methyl: when R.sub.3 -- Y is a 4-phenyl group, R.sub.2 is hydrogen and X is CO; when R.sub.3 -- Y is a 4-benzyl group and R.sub.2 is hydrogen; and also when R.sub.3 -- Y is a 3-benzoyl group, R.sub.2 is hydrogen and X is CO.

摘要翻译： 制备抗炎组合物，其包含治疗有效量的式（I）化合物，其中X为CO或CHOH; Y是CO，氧原子或直接键; 虚线表示当Y是氧原子或直接键时任选存在的双键; R1是氢或甲基; R2是氢，氟，氯，溴，甲基，三氟甲基，甲氧基，羟基，乙酰氧基，硝基或氨基; R3是3-8个碳原子的烷基，3-8个碳原子的环烷基，3-8个碳原子的烯基，5-8个碳原子的环烯基，苯基或被1或2个选自氟的取代基取代的苯基 氯，溴，甲基，乙基，甲氧基，乙氧基，苄氧基，羟基，乙酰氧基，三氟甲基，硝基，氨基，乙酰基，甲基硫醇，甲基磺酰基，甲基氨基和二甲基氨基。

公开(公告)号：US4061779A

公开(公告)日：1977-12-06

申请号：US748676

申请日：1976-12-08

申请人： Anthony William Lake ,  Carl John Rose

发明人： Anthony William Lake ,  Carl John Rose

IPC分类号： C07C29/143 ,  C07C29/145 ,  C07C29/40 ,  C07C43/23 ,  C07C45/26 ,  C07C45/45 ,  C07C45/46 ,  C07C45/62 ,  C07C45/68 ,  C07C45/74 ,  C07C49/255 ,  C07C59/64 ,  A61K31/12 ,  C07C49/76

CPC分类号： C07C29/143 ,  C07C29/145 ,  C07C29/40 ,  C07C43/23 ,  C07C45/26 ,  C07C45/45 ,  C07C45/46 ,  C07C45/62 ,  C07C45/68 ,  C07C45/74 ,  C07C49/255 ,  C07C59/64 ,  C07C2102/26

摘要： 4-(6'-Methoxy-2'-naphthyl) butan-2-one is described as having anti-inflammatory activity and an improved therapeutic ratio.

摘要翻译： 4-（6'-甲氧基-2'-萘基）丁-2-酮被描述为具有抗炎活性和改进的治疗比。