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    Bio-sensing nanodevice
    1.
    发明授权
    Bio-sensing nanodevice 有权

    公开(公告)号：US09714941B2

    公开(公告)日：2017-07-25

    申请号：US12183916

    申请日：2008-07-31

    申请人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    发明人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54366 ,  G01N2333/726

    摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    Compositions and methods for promoting hemostasis and other physiological activities
    2.
    发明授权
    Compositions and methods for promoting hemostasis and other physiological activities 有权
    促进止血等生理活动的组成和方法

    公开(公告)号：US09364513B2

    公开(公告)日：2016-06-14

    申请号：US12199670

    申请日：2008-08-27

    申请人： Rutledge Ellis-Behnke ,  Shuguang Zhang ,  Gerald Schneider ,  Kwok-Fai So ,  David Tay ,  Yu-Xiang Liang

    发明人： Rutledge Ellis-Behnke ,  Shuguang Zhang ,  Gerald Schneider ,  Kwok-Fai So ,  David Tay ,  Yu-Xiang Liang

    IPC分类号： A61K38/08 ,  A61K9/00 ,  A61K38/10

    CPC分类号： A61L26/0047 ,  A61K9/0019 ,  A61K38/08 ,  A61K38/10 ,  A61L26/0066 ,  A61L2400/04

    摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.

    摘要翻译： 描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。 组合物可以包括其它物质（例如血管收缩剂）。 还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护性涂层的组合物并去除除了血液以外的身体物质的运动时去除部位的方法。 组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。 还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。

    Self-assembling peptide incorporating modifications and methods of use thereof
    3.
    发明授权
    Self-assembling peptide incorporating modifications and methods of use thereof 有权
    包含修饰物和使用方法的自组装肽

    公开(公告)号：US08901084B2

    公开(公告)日：2014-12-02

    申请号：US12724153

    申请日：2010-03-15

    申请人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    发明人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    IPC分类号： A61K38/00 ,  C07K14/78

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/78 ,  C07K2319/735

    摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.

    摘要翻译： 本发明提供了一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且如果存在于，将其自组装成宏观结构 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。

    Multiplexed olfactory receptor-based microsurface plasmon polariton detector
    4.
    发明授权
    Multiplexed olfactory receptor-based microsurface plasmon polariton detector 有权
    基于多重嗅觉受体的微表面等离子体激元检测器

    公开(公告)号：US08748111B2

    公开(公告)日：2014-06-10

    申请号：US13015851

    申请日：2011-01-28

    申请人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    发明人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    IPC分类号： G01N33/53 ,  C07K2/00 ,  B82Y30/00 ,  G01N33/00 ,  G01N21/55

    CPC分类号： G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

    摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    摘要翻译： 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

    Self-assembling peptides for regeneration and repair of neural tissue
    6.
    发明授权
    Self-assembling peptides for regeneration and repair of neural tissue 有权
    用于神经组织再生和修复的自组装肽

    公开(公告)号：US07846891B2

    公开(公告)日：2010-12-07

    申请号：US10968790

    申请日：2004-10-18

    申请人： Rutledge Ellis-Behnke ,  Gerald Schneider ,  Shuguang Zhang

    发明人： Rutledge Ellis-Behnke ,  Gerald Schneider ,  Shuguang Zhang

    IPC分类号： C07K14/00 ,  A61K38/00 ,  C07H21/04

    CPC分类号： A61K38/10 ,  A61K38/17

    摘要： The present invention provides methods and compositions for enhancing regeneration and/or repair of neural tissue. One method include providing a nanoscale structured material at the site of injury, wherein the nanoscale structured material provides an environment that is permissive for regeneration of neural tissue and allows axon growth from a location on one side of a site of injury or barrier to a location on the other side of the site of injury or barrier. A second method includes introducing a composition comprising self-assembling peptides into the subject at the site of injury, wherein the peptides are amphiphilic peptides that comprise substantially equal proportions of hydrophobic and hydrophilic amino acids and are complementary and structurally compatible. A variety of compositions comprising a nanoscale structured material or precursor thereof, and an additional substance such as a regeneration promoting factor, are also provided. In certain embodiments of the invention the nanoscale structured material or precursor thereof comprises self-assembling peptides. The invention further provides compositions and methods for repair of an intervertebral disc, including nucleus pulpusos repair.

    摘要翻译： 本发明提供用于增强神经组织再生和/或修复的方法和组合物。 一种方法包括在损伤部位提供纳米尺度结构材料，其中纳米尺度结构材料提供允许神经组织再生的环境，并允许轴突生长从受伤部位或障碍物位置一侧的位置 在伤害或障碍场所的另一边。 第二种方法包括将包含自组装肽的组合物在损伤部位引入受试者，其中所述肽是包含基本上相等比例的疏水和亲水氨基酸并且互补和结构相容的两亲性肽。 还提供了包含纳米尺度结构材料或其前体的多种组合物和另外的物质如再生促进因子。 在本发明的某些实施方案中，纳米级结构材料或其前体包含自组装肽。 本发明还提供了用于修复椎间盘的组合物和方法，包括髓核修复。

    Compositions and methods for promoting hemostasis and other physiological activities
    7.
    发明申请
    Compositions and methods for promoting hemostasis and other physiological activities 有权
    促进止血等生理活动的组成和方法

    公开(公告)号：US20070203062A1

    公开(公告)日：2007-08-30

    申请号：US11411745

    申请日：2006-04-25

    申请人： Rutledge Ellis-Behnke ,  Shuguang Zhang ,  Gerald Schneider ,  Kwok-Fai So ,  David Tay ,  Yu-Xiang Liang

    发明人： Rutledge Ellis-Behnke ,  Shuguang Zhang ,  Gerald Schneider ,  Kwok-Fai So ,  David Tay ,  Yu-Xiang Liang

    IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61K38/06

    CPC分类号： A61L26/0047 ,  A61K9/0019 ,  A61K38/08 ,  A61K38/10 ,  A61L26/0066 ,  A61L2400/04

    摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.

    摘要翻译： 描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。 组合物可以包括其它物质（例如血管收缩剂）。 还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护性涂层的组合物并去除除了血液以外的身体物质的运动时去除部位的方法。 组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。 还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。

    SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF
    9.
    发明申请
    SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF 有权
    自组装肽的修改及其使用方法

    公开(公告)号：US20100311640A1

    公开(公告)日：2010-12-09

    申请号：US12724153

    申请日：2010-03-15

    申请人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    发明人： Elsa Genove ,  Shuguang Zhang ,  Carlos Semino

    IPC分类号： A61K38/02 ,  C07K2/00 ,  C07K14/00 ,  C12N5/00 ,  A61P35/00 ,  A61P13/12 ,  C07K7/08 ,  C07K7/06 ,  C07K5/10 ,  C07K5/08

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/78 ,  C07K2319/735

    摘要： The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.

    摘要翻译： 本发明提供一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且当存在于 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。