公开(公告)号：US5280096A

公开(公告)日：1994-01-18

申请号：US922716

申请日：1992-07-31

申请人： Cary J. Morrow ,  Joe S. Wallace

发明人： Cary J. Morrow ,  Joe S. Wallace

IPC分类号： C12P7/18 ,  C12P7/22 ,  C12P11/00 ,  C12P17/00 ,  C12P41/00 ,  C08F12/02 ,  C08F112/02

CPC分类号： C12P7/22 ,  C12P11/00 ,  C12P17/00 ,  C12P41/004 ,  C12P7/18

摘要： Optically active polymers are of the formula ##STR1## wherein R and R.sup.1 are different from each other and are selected from the group consisting of (C.sub.1 -C.sub.20)alkyl, (C.sub.2 -C.sub.20)alkenyl, (C.sub.2 -C.sub.20)alkynyl, (C.sub.3 -C.sub.22) cycloalkyl and (C.sub.6 -C.sub.22)aryl, the alkyl, alkenyl and alkynyl further including an atom selected from the group consisting of N, O and S in the chain, the alkyl, alkenyl and alkynyl further including a substituent selected from the group consisting of (C.sub.1 -C.sub.4)alkyl and halogen atoms, the cycloalkyl and aryl further including an atom selected from the group consisting of N, O and S in the ring, and the cycloalkyl and aryl further including a substituent selected from the group consisting of (C.sub.1 -C.sub.10)alkoxy, aryloxy, halogen atoms, NO.sub.2 and NHCOR.sup.4 wherein R.sup.4 is selected from the group consisting of (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, (C.sub.2 -C.sub.6)alkynyl and (C.sub.6 -C.sub.10)aryl; R.sup.2 is selected from the group consisting of --CO--, --CO--R.sup.3 --CO--, (CH.sub.2).sub.q, --C.sub.6 H.sub.4 --, 4,4'-biphenylene and --OCNH--R.sup.3 --NHCO-- wherein R.sup.3 is selected from the group consisting of (C.sub.1 -C.sub.10)alkyl, (C.sub.2 -C.sub.10)alkenyl, (C.sub.2 -C.sub.10)alkynyl, (C.sub.4 -C.sub.20)aryl and (C.sub.3 -C.sub.20)cycloalkyl and q is from 1 to 12; m is from 1 to 10,000; and p is from 0 to m. The polymer is formed from a stereochemically pure compound.

摘要翻译： 光学活性聚合物具有下式：其中R和R 1彼此不同，并且选自（C 1 -C 20）烷基，（C 2 -C 20）烯基，（C 2 -C 20）炔基，（C 3 -C 20） -C 22）环烷基和（C 6 -C 22）芳基，所述烷基，烯基和炔基还包括在所述链中选自N，O和S的原子，所述烷基，烯基和炔基还包括选自 由（C 1 -C 4）烷基和卤素原子组成的基团，环烷基和芳基还包括在环中选自N，O和S的原子，并且环烷基和芳基还包括选自以下的取代基： 的（C 1 -C 6）烷氧基，芳氧基，卤素原子，NO 2和NHCOR 4，其中R 4选自（C 1 -C 6）烷基，（C 2 -C 6）烯基，（C 2 -C 6）炔基和（C 6 -C 10） ）芳基; R2选自-CO - ， - CO-R3-CO-，（CH2）q，-C6H4-，4,4'-联亚苯基和-OCNH-R3-NHCO-，其中R3选自 由（C1-C10）烷基，（C2-C10）烯基，（C2-C10）炔基，（C4-C20）芳基和（C3-C20）环烷基组成，q为1至12; m为1〜10,000; p为0〜m。 聚合物由立体化学纯的化合物形成。

公开(公告)号：US5166062A

公开(公告)日：1992-11-24

申请号：US470668

申请日：1990-01-26

申请人： Cary J. Morrow ,  Joe S. Wallace

发明人： Cary J. Morrow ,  Joe S. Wallace

IPC分类号： C12P7/18 ,  C12P7/22 ,  C12P11/00 ,  C12P17/00 ,  C12P41/00

CPC分类号： C12P7/22 ,  C12P11/00 ,  C12P17/00 ,  C12P41/004 ,  C12P7/18

摘要： Methods of separating the stereoisomers of secondary di- and tri-alcoholic compounds comprise reacting a racemic mixture of the secondary alcohols with an acyl anhydride or an ester in the presence of an enzyme which stereoselectively acylates the (R) site of the alcohol to form the (R) site acyl ester of the alcohol and separating the (S,S) or (S,S,S) secondary alcohol, the (R,S) or (R,S,S) monoacyl ester of the alcohol, the (R,R) or (R,R,S) diacyl ester and/or the (R,R,R) triacyl ester of the alcohol from one another and from the reaction medium. Additional methods of separating the stereoisomers of a secondary di- or tri-alcohol comprise reacting a stereochemical mixture of acyl esters of the di- or tri-alcohol with an enzyme which selectively deacylates the (R) or (S) site of the secondary alcohol to produce (R) or (S) site deacylated isomers of the secondary alcohol and separating the free alcohol, the monoacyl ester, the diacyl ester, and the triacyl ester of the alcohol from one another and the reaction medium.

摘要翻译： 分离二级和三醇类化合物的立体异构体的方法包括在酶的存在下使仲醇的外消旋混合物与酰基酸酐或酯反应，其中立体选择性酰化醇的（R）位点以形成 （S，S）或（S，S，S）仲醇，（R，S）或（R，S，S）单酰基酯，（ R，R）或（R，R，S）二酰基酯和/或醇的（R，R，R）三酰基酯和反应介质。 分离二级或三醇的立体异构体的另外的方法包括使二醇或三醇的酰基酯的立体化学混合物与选择性使仲醇的（R）或（S）位点脱酰的酶 从而产生仲醇的（R）或（S）位脱酸异构体，并将醇与单酰基酯，二酰基酯和醇的三酰基酯彼此和反应介质分离。

公开(公告)号：US5147791A

公开(公告)日：1992-09-15

申请号：US759971

申请日：1991-09-17

申请人： Cary J. Morrow ,  Joe S. Wallace

发明人： Cary J. Morrow ,  Joe S. Wallace

IPC分类号： C08G63/82 ,  C12P7/62 ,  C12P17/02

CPC分类号： C12P7/62 ,  C08G63/82 ,  C12P17/02

摘要： A method for synthesizing a polyester comprises reacting a diester and a dialcohol at approximately ambient temperature in the presence of an enzyme catalyst, preferably a lipase comprising porcine pancreatic lipase. The method is particularly adapted for enantioselective polymerization resulting in an optically active polyester. The polyesters preferably exhibit a weight average molecular weight, Mw, as measured by gel permeation chromatography of at least about 3000.

摘要翻译： 合成聚酯的方法包括在大约环境温度下在酶催化剂，优选包含猪胰脂肪酶的脂肪酶的存在下使二酯和二醇反应。 该方法特别适用于产生光学活性聚酯的对映选择性聚合。 聚酯优选表现出通过至少约3000的凝胶渗透色谱测量的重均分子量Mw。

公开(公告)号：US4169944A

公开(公告)日：1979-10-02

申请号：US834324

申请日：1977-09-19

申请人： Terence J. Scallen ,  Cary J. Morrow

发明人： Terence J. Scallen ,  Cary J. Morrow

IPC分类号： C07C29/36 ,  C07C51/34 ,  C07C51/56 ,  C07H19/20 ,  C07H17/00

CPC分类号： C07H19/20 ,  C07C29/36 ,  C07C51/34 ,  C07C51/56

摘要： Cholesterol biosynthesis inhibitors are described which are derivatives of coenzyme A having the general formula ##STR1## wherein n is 1 to 3, inclusive, and CoA is coenzyme A minus a hydrogen atom from a sulfhydryl substituent. They are produced by reacting coenzyme A with a fluorinated 3-hydroxy-3-methylglutaric anhydride of the general formula ##STR2## in dilute aqueous alkali.

公开(公告)号：US5342780A

公开(公告)日：1994-08-30

申请号：US940129

申请日：1992-09-03

申请人： Cary J. Morrow ,  Joe S. Wallace

发明人： Cary J. Morrow ,  Joe S. Wallace

IPC分类号： C07C67/48 ,  C07D303/40 ,  C12P7/62 ,  C12P17/02 ,  C12P41/00 ,  C07C67/00 ,  C12N9/20

CPC分类号： C12P41/005 ,  C07C67/48 ,  C07D303/40 ,  C12P17/02 ,  C12P7/62

摘要： Methods of separating stereoisomers of a racemic mixtures of a compound employ porcine pancreatic lipase which selectively transesterfies one enantiomer of an ester function which is proximate to a chiral isomeric site are presented. The compound is a reactive ester of the formula: ##STR1## The method comprises obtaining a racemic mixture of the reactive ester, reacting the reactive ester with a poly(ethylene glycol) of average molecular weight of about 100 to about 10,000 Daltons and the enzyme. The reactive ester, the poly(ethylene glycol) and the enzyme are reacted in a medium in proportions other conditions effective to form a chiral site proximate poly(ethylene glycol) ester. The chiral site approximate poly(ethylene glycol) ester is then separated from the reaction medium, the reactive ester, the poly(ethylene glycol) and the enzyme.

摘要翻译： 分离化合物的外消旋混合物的立体异构体的方法使用选择性酯交换邻近手性异构体位点的酯官能团的一个对映异构体的猪胰脂肪酶。 该化合物是下式的反应性酯：该方法包括获得反应性酯的外消旋混合物，使反应性酯与平均分子量为约100至约10,000道尔顿的聚（乙二醇）反应，并且酶 。 反应性酯，聚（乙二醇）和酶在介质中以有效形成邻近聚（乙二醇）酯的手性位置的其它条件的比例反应。 然后将手性位点近似的聚（乙二醇）酯与反应介质，反应性酯，聚（乙二醇）和酶分离。

公开(公告)号：US5149835A

公开(公告)日：1992-09-22

申请号：US343772

申请日：1989-04-27

申请人： Cary J. Morrow ,  Joseph M. Eridon

发明人： Cary J. Morrow ,  Joseph M. Eridon

IPC分类号： C07D309/30

CPC分类号： C07D309/30

摘要： Novel 3-hydroxyl, 5-halo derivatized mevalonolactones and a stereospecific method of preparing a transsubstituted mevalonolactone.A stereospecific method of preparing a 3-hydroxyl 5-trans mevalonolactone of the formula ##STR1## wherein n is 0-12, R' is Ch.sub.3 (CH.sub.2).sub.m, wherein m is 0-8, and Z is as defined in the specification.

摘要翻译： 新型3-羟基，5-卤素衍生的甲羟戊酸内酯和制备经取代的甲羟戊酸内酯的立体特异性方法。 制备式（II）的3-羟基-5-反式甲羟戊酸内酯的立体特异性方法，其中n为0-12，R'为Ch 3（CH 2）m，其中m为0-8，Z如所定义 在规范中。