摘要:
Use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide: and an HIV gp 120 protein or polynucleotide in the manufacture of a vaccine suitable for a prime-boost delivery for the prophylactic or therapeutic immunisation of humans against HIV, wherein the protein or polynucleotide is delivered via a bombardment approach.
摘要:
Use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide; and an HIV gp120 protein or polynucleotide in the manufacture of a vaccine suitable for a prime-boost delivery for the prophylactic or therapeutic immunisation of humans against HIV, wherein the protein or polynucleotide is delivered via a bombardment approach.
摘要:
The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment thereof and RT or a fragment thereof.
摘要:
The relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions. The invention in particular relates to DNA vaccines that are useful in the prophylaxis and treatment of HIV infections, more particularly when administered by particle mediated delivery.
摘要:
The present invention relates to the fields of vaccines, vaccine adjuvants, molecular biology and immunology, and generally adjuvants and nucleic acid immunization techniques. More specifically, the invention relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions. The invention in particular relates to DNA vaccines that are useful in the prophylaxis and treatment of HIV infections, more particularly when administered by particle mediated delivery.
摘要:
The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections and the symptoms and diseases associated therewith. More particularly, the invention relates to polynucleotide sequences which encode human papilloma virus (HPV) amino acid amino acid sequences, wherein the codon usage pattern of the polynucleotide sequences resemble those of highly expressed mammalian genes.
摘要:
Safety apparatus for firearms are described. An example safety apparatus may be used with a firearm having a latch movable between a first position to retain a breech of the firearm and a second position to enable movement of the breech. The safety apparatus includes a biased safety mechanism coupled to the latch and movable between the first position and the second position. Additionally, the safety apparatus includes a safety device moveable between a locking position and a non-locking position. The safety device interacts with the biased safety mechanism when the safety device is in the locking position and the safety mechanism is in the first position to enable the biased safety mechanism to prevent a trigger force from moving the latch to the second position but to enable the latch to be deflected by a returning breech.
摘要:
Safety apparatus for firearms are described. An example safety apparatus may be used with a firearm having a latch movable between a first position to retain a breech of the firearm and a second position to enable movement of the breech. The safety apparatus includes a biased safety mechanism coupled to the latch and movable between the first position and the second position. Additionally, the safety apparatus includes a safety device moveable between a locking position and a non-locking position. The safety device interacts with the biased safety mechanism when the safety device is in the locking position and the safety mechanism is in the first position to enable the biased safety mechanism to prevent a trigger force from moving the latch to the second position but to enable the latch to be deflected by a returning breech.
摘要:
The invention is directed at apparatus for high-speed acquisition of electrochemical measurements from multiple biochemical or microbiological samples comprising an array of electrodes; a voltage signal generator for the array of electrodes; and means for collecting electrochemical measurements from the electrodes; wherein when the electrodes are brought in contact with the multiple biochemical or microbiological samples, the voltage signal generator provides a voltage to each of the electrodes to produce the electrochemical measurements for the means for collecting to retrieve.
摘要:
The invention relates to polynucleotides for DNA vaccination which polynucleotides encode an HIV envelope protein or fragment or immunogenic derivative fused to an additional HIV protein selected from a non-structural protein or capsid protein or fragment or immunogenic derivative thereof. Preferably the HIV envelope molecule is gp120 and preferred fusions include one or more of HIV Nef, Gag, RT or Tat. Preferably the HIV envelope molecule is non-glycosylated in mammalian cells.