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    ANTI-C-MET ANTIBODY HAVING HGF ACTIVITY AND USE THEREOF
    2.
    发明申请
    ANTI-C-MET ANTIBODY HAVING HGF ACTIVITY AND USE THEREOF 有权
    具有HGF活性的抗C-MET抗体及其用途

    公开(公告)号：US20140193431A1

    公开(公告)日：2014-07-10

    申请号：US14123533

    申请日：2012-06-04

    申请人： Young Woo Park ,  KiWon Jo ,  Chan Woong Park ,  Seok Ho Yoo ,  Myeoung Hee Jang ,  Hye Nan Kim ,  Seon Ha Yun ,  Kyu Won Cho ,  Mi Ra Park

    发明人： Young Woo Park ,  KiWon Jo ,  Chan Woong Park ,  Seok Ho Yoo ,  Myeoung Hee Jang ,  Hye Nan Kim ,  Seon Ha Yun ,  Kyu Won Cho ,  Mi Ra Park

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

    摘要： Disclosed are a human antibody comprising a human complementarity-determining region (CDR), which binds specifically to c-Met, and a framework region (FR), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody B7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-Met-specific human antibody can function as an HGF mimic that can be used as a wound healing composition. The antibody can be widely used to determine the treatment and prognosis of various diseases, including neuronal infarction, progressive nephropathy, liver cirrhosis, lung fibrosis, kidney injury, liver injury, lung injury, and ulcerative wounds, which are treated by activation of HGF or c-Met.

    摘要翻译： 公开了包含与c-Met特异性结合的人互补决定区（CDR）的人抗体和框架区（FR），编码人抗体的多核苷酸，包含多核苷酸的表达载体，转化了 表达载体，通过培养转化体生产人抗体B7的方法，包含人抗体作为活性成分的伤口愈合组合物，包含抗体作为活性成分的细胞再生组合物和包含药物连接的药物偶联物 对人抗体。 c-Met特异性人抗体可用作可用作伤口愈合组合物的HGF模拟物。 该抗体可广泛用于确定通过激活HGF或其他疾病治疗的各种疾病的治疗和预后，包括神经元梗死，进行性肾病，肝硬化，肺纤维化，肾损伤，肝损伤，肺损伤和溃疡性创伤 c-Met。

    METHOD AND APPARATUS FOR A HIGH VOLTAGE POWER SUPPLY CIRCUIT
    7.
    发明申请
    METHOD AND APPARATUS FOR A HIGH VOLTAGE POWER SUPPLY CIRCUIT 失效
    高压电源电路的方法和装置

    公开(公告)号：US20110199795A1

    公开(公告)日：2011-08-18

    申请号：US13072585

    申请日：2011-03-25

    申请人： Chan Woong Park ,  Leif O. Lund

    发明人： Chan Woong Park ,  Leif O. Lund

    IPC分类号： H02M3/335

    CPC分类号： H02M3/33507 ,  H02M3/156

    摘要： A power converter is disclosed. An example power converter includes an energy transfer element coupled between a power converter input and a power converter output. A power switch is coupled to the energy transfer element. A control circuit is coupled to receive a feedback signal representative of the power converter output during a feedback portion of an off time of the power switch. The control circuit is coupled to generate an output signal in response to the feedback signal. The output signal is coupled to be received by the power switch to control switching of the power switch to control a fraction of the feedback portion of the off time of the power switch that the feedback signal is above a threshold and another fraction of the feedback portion of the off time of the power switch that the feedback signal is below the threshold.

    摘要翻译： 公开了一种功率转换器。 示例性功率转换器包括耦合在功率转换器输入和功率转换器输出之间的能量传递元件。 功率开关耦合到能量传递元件。 控制电路被耦合以在功率开关的关闭时间的反馈部分期间接收表示功率转换器输出的反馈信号。 控制电路被耦合以响应于反馈信号而产生输出信号。 输出信号被耦合以由电源开关接收以控制功率开关的切换以控制反馈信号高于阈值的反馈部分关闭时间的反馈部分的一部分，反馈部分的另一部分 电源开关的关闭时间，反馈信号低于阈值。

    Method and apparatus for regulating an output current from a power converter
    8.
    发明授权
    Method and apparatus for regulating an output current from a power converter 有权
    用于调节来自功率转换器的输出电流的方法和装置

    公开(公告)号：US07839660B2

    公开(公告)日：2010-11-23

    申请号：US12487457

    申请日：2009-06-18

    申请人： Chan Woong Park

    发明人： Chan Woong Park

    IPC分类号： H02M3/335

    CPC分类号： H02M3/33507 ,  H02M3/156

    摘要： Techniques are disclosed to regulate an output current through a load coupled to a power converter using a current source coupled to the load. For instance, one power converter according to the teachings of the present invention includes an energy transfer element coupled between an input of the power converter and an output of the power converter. A power converter controller is coupled to the energy transfer element to control a transfer of energy from the input of the power converter to the output of the power converter. A load is to be coupled to the output of the power converter. A current source is to be coupled to the load. The current source regulates the current flowing through the load to a threshold current value. The current source is coupled to sense a current through the load. A switch having a first and second end is also included. The first end is to be coupled to the load and the second end is coupled to the current source. The switch is coupled to be switched on and off at a duty cycle to control an average current through the load. The current through the load is substantially equal to a current through the switch and the current source.

    摘要翻译： 公开了技术来调节通过耦合到功率转换器的负载使用耦合到负载的电流源的负载的输出电流。 例如，根据本发明的教导的一个功率转换器包括耦合在功率转换器的输入端和功率转换器的输出端之间的能量传递元件。 电力转换器控制器耦合到能量传递元件以控制从功率转换器的输入到功率转换器的输出的能量传递。 负载将耦合到功率转换器的输出。 电流源将耦合到负载。 电流源将流过负载的电流调节到阈值电流值。 电流源被耦合以感测通过负载的电流。 还包括具有第一端和第二端的开关。 第一端被耦合到负载，并且第二端耦合到电流源。 开关被耦合以在占空比下接通和关断以控制通过负载的平均电流。 通过负载的电流基本上等于通过开关和电流源的电流。

    COMPOSITION OF SKIN EXTERNAL APPLICATION CONTAINING GINSENG BERRY EXTRACTS
    9.
    发明申请
    COMPOSITION OF SKIN EXTERNAL APPLICATION CONTAINING GINSENG BERRY EXTRACTS 有权
    含金山莓提取物的皮肤外用剂组合物

    公开(公告)号：US20100189821A1

    公开(公告)日：2010-07-29

    申请号：US12602421

    申请日：2008-05-30

    申请人： Chan Woong Park ,  Myeong Hoon Yeom ,  Jin Young Lee ,  Hee Young Jeon ,  Sang Jun Lee ,  Nam Hoon Cho ,  Dong Sung Lee

    发明人： Chan Woong Park ,  Myeong Hoon Yeom ,  Jin Young Lee ,  Hee Young Jeon ,  Sang Jun Lee ,  Nam Hoon Cho ,  Dong Sung Lee

    IPC分类号： A61K8/97 ,  A61Q19/08 ,  A61K36/254 ,  A61P29/00 ,  A61P17/10

    CPC分类号： A23L1/3002 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/97 ,  A61K36/258 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08 ,  A23V2250/2124 ,  A23V2200/318 ,  A23V2200/332

    摘要： Disclosed herein is a. skin external composition containing ginseng berry extract. More specifically, disclosed is a skin external composition, which contains, as an active ingredient, ginseng berry extract having the specific components and compositions, among the above-ground parts of ginseng, and thus promotes the production of collagen in the skin, shows an MMP-I inhibitory effect and, at the same time, has skin-aging inhibitory and wrinkle-reducing effects, resulting from antioxidant effects and DNA damage-protecting effects. Also disclosed is a skin external composition, which contains, as an active ingredient, ginseng berry extract, which has a skin whitening effect resulting from the effects of inhibiting melanin production and reducing pigmentation caused by UV radiation, the effects of relieving dry skin symptoms and atopic symptoms by inducing and maintaining the normal differentiation of skin keratinocytes, the effect of relieving acne and skin troubles by the regulation of sebum secretion and an anti-inflammatory effect, and makes complexion ruddy through the improvement of peripheral blood circulation to make the skin clean and clear. Also disclosed is a food composition for reducing and preventing obesity, which contains, as an active ingredient, ginseng berry extract, which increases the expression of a carnitine palmitoyl transterase-1 (CPT-I) gene, serves to transport fatty acids into mitochondria in fatty acid oxidation and promotes fat oxidation.

    摘要翻译： 本文公开的是 皮肤外用组合物含人参浆果提取物。 更具体地，公开了皮肤外用组合物，其含有人参的地上部分中具有特定成分和组成的人参浆果提取物作为活性成分，从而促进皮肤中的胶原蛋白的生成，显示出 MMP-1抑制作用，同时具有由抗氧化作用和DNA损伤保护作用产生的皮肤衰老抑制和皱纹减轻作用。 还公开了一种皮肤外用组合物，其含有作为活性成分的人参浆果提取物，其具有由抑制黑色素产生和减少由紫外线辐射引起的色素沉着的作用而产生的皮肤美白效果，减轻干性皮肤症状的效果和 通过诱导和维持皮肤角质形成细胞的正常分化，减轻痤疮和皮肤麻烦的作用，通过调节皮脂分泌和抗炎作用而产生特应性症状，并通过改善外周血液循环使肤色变红，使皮肤清洁 并清楚 还公开了用于减少和预防肥胖的食物组合物，其包含增加肉碱棕榈酰转铁蛋白-1（CPT-1）基因表达的人参浆果提取物作为活性成分，用于将脂肪酸运输到线粒体中 脂肪酸氧化并促进脂肪氧化。

    CIRCUIT FOR OUTPUT VOLTAGE ERROR DETECT AND FEEDBACK IN SMPS
    10.
    发明申请
    CIRCUIT FOR OUTPUT VOLTAGE ERROR DETECT AND FEEDBACK IN SMPS 失效
    输出电压检测电路和SMPS反馈电路

    公开(公告)号：US20090268487A1

    公开(公告)日：2009-10-29

    申请号：US12513149

    申请日：2007-10-22

    申请人： Chan Woong Park

    发明人： Chan Woong Park

    IPC分类号： H02M3/28

    CPC分类号： H02M3/33507 ,  H02M2001/0038

    摘要： The present invention relates to an error information detection circuit and an error feedback circuit, which detect the error of an output voltage from a voltage induced to a winding. The circuit for detecting error information of an output voltage of a transformer from voltage induced to the feedback winding of the transformer and feeding back the error information includes a flyback period detection circuit (34) for detecting a flyback period from a voltage induced to the feedback winding. A comparison unit (35) compares the induced voltage of the feedback winding with a reference voltage and outputs a result of comparison. A logic unit (36) outputs error information of an output voltage of the transformer according to a flyback period detection output of the flyback period detection circuit and the output of the comparison unit. An up/down control unit (32) outputs a feedback value corresponding to the error information.

    摘要翻译： 误差信息检测电路和误差反馈电路技术领域本发明涉及从感应到绕组的电压检测输出电压的误差的误差信息检测电路和误差反馈电路。 用于检测变压器的输出电压的误差信息的电路，由电压引起的变压器的反馈绕组和反馈误差信息的反馈周期检测电路（34）检测从反馈电压到反馈的电压 绕组。 比较单元（35）将反馈绕组的感应电压与参考电压进行比较，并输出比较结果。 逻辑单元（36）根据回扫周期检测电路的回扫周期检测输出和比较单元的输出，输出变压器的输出电压的误差信息。 上/下控制单元（32）输出与错误信息对应的反馈值。