公开(公告)号：US20070142273A1

公开(公告)日：2007-06-21

申请号：US10553730

申请日：2004-04-16

申请人： Sherif Daouti ,  Chandrika Kumar ,  Brian Latario

发明人： Sherif Daouti ,  Chandrika Kumar ,  Brian Latario

IPC分类号： A61K38/17 ,  C12Q1/68 ,  G01N33/567

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/745 ,  G01N2333/91215 ,  G01N2500/00 ,  G01N2800/102 ,  G01N2800/105

摘要： The invention discloses that members of a subfamily of receptor tyrosine kinases comprising TYRO3, Axl, cMer and ligands thereof, such as GAS6 are suitable targets for the development of new therapeutics to treat, prevent or ameliorate OA. The invention also relates to methods to treat and/or ameliorate OA and pharmaceutical compositions therefore comprising modulators with inhibitory effect on the expression or activity of members of this subfamily of receptor tyrosine and related ligands. The invention also relates to a method to identify compounds with therapeutic usefulness to treat OA, comprising identifying compounds that can, e.g., inhibit activity and/or expression of these polypeptides.

摘要翻译： 本发明公开了包含TYRO3，Ax1，cMer及其配体如GAS6的受体酪氨酸激酶亚家族的成员是开发治疗，预防或改善OA的新疗法的合适靶标。 本发明还涉及治疗和/或改善OA和/或药物组合物的方法，因此包括对受体酪氨酸和相关配体的亚家族成员的表达或活性具有抑制作用的调节剂。 本发明还涉及鉴定具有治疗OA作用的化合物的方法，其包括鉴定能够例如抑制这些多肽的活性和/或表达的化合物。

公开(公告)号：US6143519A

公开(公告)日：2000-11-07

申请号：US30970

申请日：1998-02-26

申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  C12N15/00

CPC分类号： C07K14/70571 ,  C07K14/72 ,  C07K14/723 ,  A61K38/00 ,  C12N2799/026

摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

公开(公告)号：US5750370A

公开(公告)日：1998-05-12

申请号：US465687

申请日：1995-06-06

申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  C07H21/00

CPC分类号： C07K14/70571 ,  C07K14/72 ,  C07K14/723 ,  A61K38/00 ,  C12N2799/026

摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertesnion, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, cyclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

摘要翻译： 公开了人内皮素 - 铃蟾肽受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽识别这种多肽的激动剂和拮抗剂的方法。 本发明的内皮素 - 铃蟾肽受体多肽的激动剂可用于治疗哮喘，帕金森病，急性心力衰竭，低血压和骨质疏松症。 抗这种多肽的拮抗剂可以治疗性地用于治疗高渗，溃疡发生，蛛网膜下腔出血，哮喘，肿瘤，环孢菌素毒性，癌症和败血性休克。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

公开(公告)号：US20060188885A1

公开(公告)日：2006-08-24

申请号：US10553520

申请日：2004-04-16

申请人： Dale Bodian ,  Sherif Daouti ,  Chandrika Kumar ,  Brian Latario ,  Joseph Quintavalla

发明人： Dale Bodian ,  Sherif Daouti ,  Chandrika Kumar ,  Brian Latario ,  Joseph Quintavalla

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： High-throughput functional screening assays are provided that identify genes and gene products that are associated with the pathogenesis of osteoarthritis (OA) in chondrocytes. In addition, genes and gene products identified by such functional assays are also provided. The genes and gene products provided herein are useful inter alia for diagnosing OA in individuals and as drug targets for identifying drugs to treat OA.

摘要翻译： 提供了高通量功能筛选测定法，其鉴定与软骨细胞中骨关节炎（OA）的发病机制相关的基因和基因产物。 此外，还提供了通过这种功能测定鉴定的基因和基因产物。 本文提供的基因和基因产物特别用于诊断个体中的OA，以及用于鉴定用于治疗OA的药物的药物靶标。

公开(公告)号：US06518404B1

公开(公告)日：2003-02-11

申请号：US09520210

申请日：2000-03-07

申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

IPC分类号： C07K1628

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/72 ,  C07K14/723 ,  C12N2799/026

摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

摘要翻译： 人内皮素 - 铃蟾肽受体多肽和编码这种多肽的DNA（RNA）和用于公开的方法。 还公开了利用这种多肽识别这种多肽的激动剂和拮抗剂的方法。 本发明的内皮素 - 铃蟾肽受体多肽的激动剂可用于治疗哮喘，帕金森病，急性心力衰竭，低血压和骨质疏松症。 抗这种多肽的拮抗剂可以治疗性地用于治疗高血压，溃疡发生，蛛网膜下腔出血，哮喘，肿瘤，环孢菌素毒性，癌症和败血性休克。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

公开(公告)号：US20070299024A1

公开(公告)日：2007-12-27

申请号：US10578469

申请日：2004-05-11

申请人： Chandrika Kumar

发明人： Chandrika Kumar

IPC分类号： A61K31/711 ,  A61P19/02 ,  C12N15/11 ,  C12N15/85 ,  C12N5/10 ,  C12P19/34 ,  C12Q1/68

CPC分类号： C12N9/50 ,  C12N9/6421 ,  C12Y304/24082

摘要： Disclosed is a nucleic acid comprising Agg promoters and methods of using the same. The invention also provides methods for identifying and treating disease based on the activity of Agg promoters.

摘要翻译： 公开了包含Agg启动子的核酸及其使用方法。 本发明还提供了基于Agg启动子的活性鉴定和治疗疾病的方法。