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403 条记录 (耗时 0.047 秒)

    Human endothelin-bombesin receptor antibodies
    1.
    发明授权
    Human endothelin-bombesin receptor antibodies 有权
    人内皮素 - 铃蟾肽受体抗体

    公开(公告)号：US06518404B1

    公开(公告)日：2003-02-11

    申请号：US09520210

    申请日：2000-03-07

    申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

    发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

    IPC分类号： C07K1628

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/72 ,  C07K14/723 ,  C12N2799/026

    摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

    摘要翻译： 人内皮素 - 铃蟾肽受体多肽和编码这种多肽的DNA（RNA）和用于公开的方法。 还公开了利用这种多肽识别这种多肽的激动剂和拮抗剂的方法。 本发明的内皮素 - 铃蟾肽受体多肽的激动剂可用于治疗哮喘，帕金森病，急性心力衰竭，低血压和骨质疏松症。 抗这种多肽的拮抗剂可以治疗性地用于治疗高血压，溃疡发生，蛛网膜下腔出血，哮喘，肿瘤，环孢菌素毒性，癌症和败血性休克。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

    Human endothelin-bombesin receptor
    2.
    发明授权
    Human endothelin-bombesin receptor 失效

    公开(公告)号：US6143519A

    公开(公告)日：2000-11-07

    申请号：US30970

    申请日：1998-02-26

    申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

    发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  C12N15/00

    CPC分类号： C07K14/70571 ,  C07K14/72 ,  C07K14/723 ,  A61K38/00 ,  C12N2799/026

    摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

    Nucleic acid encoding human endothlein-bombesin receptor and method of producing the receptor
    3.
    发明授权
    Nucleic acid encoding human endothlein-bombesin receptor and method of producing the receptor 失效
    编码人内皮素 - 铃蟾肽受体的核酸和产生受体的方法

    公开(公告)号：US5750370A

    公开(公告)日：1998-05-12

    申请号：US465687

    申请日：1995-06-06

    申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

    发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  C07H21/00

    CPC分类号： C07K14/70571 ,  C07K14/72 ,  C07K14/723 ,  A61K38/00 ,  C12N2799/026

    摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertesnion, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, cyclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

    摘要翻译： 公开了人内皮素 - 铃蟾肽受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽识别这种多肽的激动剂和拮抗剂的方法。 本发明的内皮素 - 铃蟾肽受体多肽的激动剂可用于治疗哮喘，帕金森病，急性心力衰竭，低血压和骨质疏松症。 抗这种多肽的拮抗剂可以治疗性地用于治疗高渗，溃疡发生，蛛网膜下腔出血，哮喘，肿瘤，环孢菌素毒性，癌症和败血性休克。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

    Human G-Protein Coupled Receptor (HETGQ23)
    4.
    发明申请
    Human G-Protein Coupled Receptor (HETGQ23) 审中-公开
    人类G蛋白偶联受体（HETGQ23）

    公开(公告)号：US20110112177A1

    公开(公告)日：2011-05-12

    申请号：US12943202

    申请日：2010-11-10

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K31/7052 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C12N5/00 ,  C12P21/00 ,  C12N15/74 ,  C07K14/435 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  A61P9/12 ,  A61P9/10 ,  A61P25/00

    CPC分类号： C07K14/705

    摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    Human G-Protein Coupled Receptor
    5.
    发明申请
    Human G-Protein Coupled Receptor 审中-公开
    人类G蛋白偶联受体

    公开(公告)号：US20110033470A1

    公开(公告)日：2011-02-10

    申请号：US12831336

    申请日：2010-07-07

    申请人： Yi Li ,  Craig A. Rosen

    发明人： Yi Li ,  Craig A. Rosen

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  C07K14/705 ,  C07K16/28 ,  G01N33/566 ,  C12Q1/68 ,  A61K38/02 ,  C07K2/00 ,  A61P43/00

    CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K14/705

    摘要： A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the G-protein coupled receptor. Also disclosed are assays for detecting mutations in the nucleic acid sequence encoding the G-protein coupled receptor.

    摘要翻译： 公开了人G-蛋白偶联受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽鉴定此类多肽的拮抗剂和激动剂的方法。 拮抗剂和激动剂可用于治疗性地抑制或刺激G蛋白偶联受体。 还公开了用于检测编码G蛋白偶联受体的核酸序列中的突变的测定法。

    Human amine transporter polypeptide fragments
    8.
    发明授权
    Human amine transporter polypeptide fragments 失效
    人类胺转运蛋白多肽片段

    公开(公告)号：US6117426A

    公开(公告)日：2000-09-12

    申请号：US139675

    申请日：1998-08-25

    申请人： Yi Li ,  Liang Cao ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K39/395 ,  C07H21/04 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  C12P21/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.

    摘要翻译： 公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。 还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

    Human G-protein receptor HCEGH45
    9.
    发明授权
    Human G-protein receptor HCEGH45 失效
    人类G蛋白受体HCEGH45

    公开(公告)号：US5869632A

    公开(公告)日：1999-02-09

    申请号：US465976

    申请日：1995-06-06

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07K14/72 ,  C07K14/705 ,  A61K38/00

    摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了人类G蛋白受体HCEGH45多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。 针对这种多肽的拮抗剂可以用于治疗PACAP过度分泌病症并产生药理学遗忘症模型，同时激动剂可用于治疗遗忘症和阿尔茨海默氏病。 还公开了用于检测受体核酸序列中的突变并检测衍生自宿主的样品中可溶形式的受体的诊断方法。

    Human amine transporter
    10.
    发明授权
    Human amine transporter 失效
    人类胺转运蛋白

    公开(公告)号：US5859200A

    公开(公告)日：1999-01-12

    申请号：US894840

    申请日：1998-01-30

    申请人： Yi Li ,  Liang Cao ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  C07K14/47

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the under-expression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.

    摘要翻译： PCT No.PCT / US95 / 02645 Sec。 371日期1998年1月30日 102（e）日期1998年1月30日PCT 1995年3月1日PCT公布。 公开号WO96 / 27009 日本1996年9月6日公开了一种编码这种多肽的人胺转运蛋白多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达有关的疾病。 还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。