Phosphorylated A2A Receptor Agonists
    3.
    发明申请
    Phosphorylated A2A Receptor Agonists 审中-公开
    磷酸化A2A受体激动剂

    公开(公告)号:US20100048501A1

    公开(公告)日:2010-02-25

    申请号:US12293983

    申请日:2007-03-21

    CPC分类号: C07H19/20

    摘要: A phosphorylated A2A receptor agonist providing agonist properties on the A2A receptor after dephosphorylation the phosphorylated A2A receptor agonist comprises a ribosyl moiety and a purine moiety and being phosphorylated at the 5′-position of the ribose moiety except adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), a medicament containing the compound of the invention including ADP and the use of the compound of the invention including ATP and ADP for several medical indications e. g. inflammatory events. In particular, compounds of formula (I) are also disclosed.

    摘要翻译: 在磷酸化A2A受体激动剂脱磷酸化后,在A2A受体上提供激动剂性质的磷酸化A2A受体激动剂包含核糖基部分和嘌呤部分,并且在核糖部分的5'-位被磷酸化,除了腺苷一磷酸(AMP),二磷酸腺苷 ADP)或三磷酸腺苷(ATP),含有包含ADP的本发明化合物的药物,以及包括ATP和ADP在内的多种医学适应症的本发明化合物的用途。 G。 炎性事件。 特别地,还公开了式(I)的化合物。