公开(公告)号：US20100048501A1

公开(公告)日：2010-02-25

申请号：US12293983

申请日：2007-03-21

申请人： Jurgen Schrader ,  Christa Muller ,  All El-Tayeb ,  Jamshed Iqbal

发明人： Jurgen Schrader ,  Christa Muller ,  All El-Tayeb ,  Jamshed Iqbal

IPC分类号： A61K31/7076 ,  C07H19/20 ,  G01N33/53 ,  A61P19/00 ,  A61P25/00

CPC分类号： C07H19/20

摘要： A phosphorylated A2A receptor agonist providing agonist properties on the A2A receptor after dephosphorylation the phosphorylated A2A receptor agonist comprises a ribosyl moiety and a purine moiety and being phosphorylated at the 5′-position of the ribose moiety except adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), a medicament containing the compound of the invention including ADP and the use of the compound of the invention including ATP and ADP for several medical indications e. g. inflammatory events. In particular, compounds of formula (I) are also disclosed.

摘要翻译： 在磷酸化A2A受体激动剂脱磷酸化后，在A2A受体上提供激动剂性质的磷酸化A2A受体激动剂包含核糖基部分和嘌呤部分，并且在核糖部分的5'-位被磷酸化，除了腺苷一磷酸（AMP），二磷酸腺苷 ADP）或三磷酸腺苷（ATP），含有包含ADP的本发明化合物的药物，以及包括ATP和ADP在内的多种医学适应症的本发明化合物的用途。 G。 炎性事件。 特别地，还公开了式（I）的化合物。

公开(公告)号：US06200304B1

公开(公告)日：2001-03-13

申请号：US09112519

申请日：1998-07-09

申请人： Jurgen Schrader

发明人： Jurgen Schrader

IPC分类号： A61M3100

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N9/0075 ,  C12N2750/14143

摘要： The present invention relates to a transfection system comprising one or more Infiltrator catheters, one or more non-viral nucleic acids, and, where appropriate, suitable ancillary substances and/or additives, and to its preparation and use in somatic gene therapy.

摘要翻译： 本发明涉及一种转染系统，其包含一种或多种浸润器导管，一种或多种非病毒核酸，以及适当的合适的辅助物质和/或添加剂，以及其在体细胞基因治疗中的制备和用途。

公开(公告)号：US6149936A

公开(公告)日：2000-11-21

申请号：US123624

申请日：1998-07-28

申请人： Jurgen Schrader ,  Axel Godecke

发明人： Jurgen Schrader ,  Axel Godecke

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C12N9/00 ,  C12N9/02 ,  C12N15/85 ,  C12R1/91 ,  A61K3/127 ,  A61K31/7088

CPC分类号： C12N9/0075 ,  A61K47/48776 ,  C12N15/85 ,  A61K38/00 ,  A61K48/00 ,  C12N2800/108 ,  C12N2830/42

摘要： A DNA expression vector is described which is characterized in that it comprises a DNA sequence that codes a protein which possesses the biological activity of nitrogen monoxide synthase (NOS) and eukaryotic regulation elements, wherein said eukaryotic regulation elements result in the expression of said DNA sequence in eukaryotic cells, as well as the use of the expression vector for treatment or prevention of vascular disorders.

摘要翻译： 描述了DNA表达载体，其特征在于其包含编码具有一氧化氮合酶（NOS）和真核调节元件的生物活性的蛋白质的DNA序列，其中所述真核调节元件导致所述DNA序列的表达 在真核细胞中，以及使用表达载体治疗或预防血管疾病。

公开(公告)号：US5707099A

公开(公告)日：1998-01-13

申请号：US718936

申请日：1996-09-24

申请人： Jurgen Schrader ,  Martin Lorenz ,  Stephan Orth

发明人： Jurgen Schrader ,  Martin Lorenz ,  Stephan Orth

IPC分类号： B60J7/22 ,  B60N2/90 ,  B62D35/00

CPC分类号： B60N2/44 ,  B60J7/223

摘要： On the cross traverse of at least one convertible automobile rollover bar, a wind net is supported on a span at least approximately the surface between the lateral members of the rollover bar. The upper edge of the wind net rests on an exterior side of the cross traverse in a tensioned manner, and the wind net itself extends down only to approximately the level of the vehicle edge.

摘要翻译： 在至少一个可转换的汽车翻车杆的横向横移上，风网至少在翻转杆的横向构件之间的表面上支撑在跨距上。 风网的上边缘以张紧的方式搁置在横向横移的外侧上，并且风网本身仅向下延伸到车辆边缘的大致水平。

公开(公告)号：US5295722A

公开(公告)日：1994-03-22

申请号：US899847

申请日：1992-06-17

申请人： Andreas Bonne ,  Martin Guckel ,  Jurgen Schrader ,  Klaus Claar

发明人： Andreas Bonne ,  Martin Guckel ,  Jurgen Schrader ,  Klaus Claar

IPC分类号： B60J7/12 ,  B60J7/185 ,  B60J7/20 ,  B60J7/08

CPC分类号： B60J7/1226 ,  B60J7/1247 ,  B60J7/198 ,  B60J7/202

摘要： A retractable folding top for motor vehicles, having a top frame which comprises a material retaining hoop forming the lower termination of the top, and a top storage box for accommodating the folded top. The top storage box can be closed by a top storage box lid, following which it is held shut by a closure. The top has a position of rest of the material retaining hoop on the top storage box lid when the top is closed, in which the material retaining hoop is noncontinuously connected to the top storage box lid via a closure arrangement. To simplify operation, the closure arrangement between the material retaining hoop and the top storage box lid has only a single closure which is arranged in the central region of the overlap zone between the top storage box lid and the material retaining hoop.

摘要翻译： 一种用于机动车辆的可伸缩折叠顶部，具有顶部框架，该顶部框架包括形成顶部的下端接件的材料保持环和用于容纳折叠顶部的顶部存放箱。 顶部储物箱可以通过顶部储物箱盖关闭，然后由盖子关闭。 当顶部关闭时，顶部具有剩余的材料保持箍的位置，顶盖被封闭，其中材料保持箍通过封闭装置不连续地连接到顶部存储箱盖。 为了简化操作，材料保持环和顶部储物箱盖之间的封闭装置仅具有单个封闭件，该封闭件布置在顶部储存箱盖和材料保持环之间的重叠区域的中心区域中。

公开(公告)号：US5267770A

公开(公告)日：1993-12-07

申请号：US933783

申请日：1992-08-24

申请人： Stefan Orth ,  Karl Koster ,  Klaus P. Claar ,  Jurgen Schrader ,  Walter Cornel ,  Helmut Rottler ,  Martin Guckel

发明人： Stefan Orth ,  Karl Koster ,  Klaus P. Claar ,  Jurgen Schrader ,  Walter Cornel ,  Helmut Rottler ,  Martin Guckel

IPC分类号： B60J1/18 ,  B60J7/00

CPC分类号： B60J1/1815

摘要： The invention relates to a folding top for motor vehicles with a dimensionally stable rear window which, when the top is opened, can be folded down from an upright, position of use into a flat position of non-use. The top cover encloses the rear window and is connected along the lower edge side of the rear window and laterally thereto to a material retaining section arranged at the lower termination of the top. The rear window exhibits an axis of articulation extending approximately parallel to the lower edge side of the rear window which is displaced rearwards relative to the material retaining section during movement of the rear window toward a position of non-use. The axis of articulation is arranged to be displaceable to ensure the displaceability of the rear window. In order also to permit appropriate rearward displacement of the rear window with top arrangements in which the lower edge side of the rear window extends at a relatively short distance from the material retaining hoop when the top is closed, the top cover is provided on both sides of the rear window with a fabric zone of variable length, the fabric zones being capable of being drawn apart by the rearward displacement of the rear window when the folding top is laid flat and being capable of shortening to their initial length when the folding top is erected into the closed position of use.

摘要翻译： 本发明涉及一种具有尺寸稳定的后窗的机动车辆的折叠顶部，当顶部打开时，其可以从直立的使用位置向下折叠到不使用的平坦位置。 顶盖包围后窗，并沿着后窗的下边缘侧向侧面连接到布置在顶部下端的材料保持部分。 后窗具有大致平行于后窗的下边缘侧延伸的铰接轴线，该后轴线在后窗朝向不使用位置移动期间相对于材料保持部分向后移位。 铰接轴被布置成可移位以确保后窗的可移动性。 为了允许后窗的适当的后向位移，当顶部关闭时，后窗的下边缘侧在与材料保持环相距较短的距离处延伸的顶部布置中，顶盖设置在两侧 的后窗具有可变长度的织物区域，当折叠顶部平放时，织物区域能够通过后窗的向后移位而被分开，并且当折叠顶部是折叠顶部时，能够缩短到其初始长度 竖立在封闭的使用位置。

公开(公告)号：US4929020A

公开(公告)日：1990-05-29

申请号：US254806

申请日：1988-10-07

申请人： Jurgen Schrader ,  Klaus Claar

发明人： Jurgen Schrader ,  Klaus Claar

IPC分类号： B60J7/12

CPC分类号： B60J7/1234

摘要： The invention relates to a strut for a folding vehicle cover which bridges the roof width by being braced axially on load bearing connecting components on both sides of the vehicle by angled strut flanks, while a strut section driven by a spring loading arrangement is raisable in the strut plane relative to the braced ends of the strut flanks into a tensioned position in which the roof skin of the folding cover is stressed by the spring loading arrangement through the strut section, and while a further vertical displacement of the strut section is locked upon reaching a limit time position located above the tensioned position. To facilitate the operation of the strut, it is provided that the strut is integrated into the cover frame of the folding cover by its strut flanks being braced articulately against associated side wall frame parts, that the strut section is retained in the locked limit position during the course of the closing movement of the folding cover until a taut roof skin is obtained, and that in a final closing phase of the folding cover it is automatically lowerable out of its limit position counter to the spring loading arrangement into its tensioned position under the influence of longitudinal tensile forces in the roof skin.

摘要翻译： 本发明涉及一种用于折叠车辆罩的支柱，其通过在倾斜的支柱侧面上在车辆的两侧的承载连接部件上轴向地支撑车顶宽度，而由弹簧加载装置驱动的支柱部分可以在 相对于支柱的支撑端部的支柱平面侧面成为张紧位置，其中折叠盖的屋顶表面通过支撑部分的弹簧加载布置而受到应力，并且当支柱段进一步垂直移位时，锁定到达 位于张紧位置上方的极限时间位置。 为了便于支柱的操作，提供了支柱通过其支柱侧面被铰接地支撑在相关联的侧壁框架部件上而被整合到折叠盖的盖框架中，支柱部分被保持在锁定极限位置 折叠盖的关闭运动的过程直到获得拉紧的屋顶皮肤，并且在折叠盖的最终关闭阶段中，它可以自动地从与弹簧加载装置相反的极限位置降低到其在下面的张紧位置 屋顶皮肤纵向拉伸力的影响。

公开(公告)号：US4815775A

公开(公告)日：1989-03-28

申请号：US105352

申请日：1987-10-07

申请人： Ralf Mertin ,  Klaus Claar ,  Jan Schilling ,  Jurgen Schrader ,  Holger Seel ,  Helmut Staiger ,  Artur Mangold ,  Gerhard Zweigart

发明人： Ralf Mertin ,  Klaus Claar ,  Jan Schilling ,  Jurgen Schrader ,  Holger Seel ,  Helmut Staiger ,  Artur Mangold ,  Gerhard Zweigart

IPC分类号： E05B81/20 ,  E05C3/26

CPC分类号： E05B81/20 ,  Y10S292/05 ,  Y10S292/14 ,  Y10T292/1047 ,  Y10T292/1082

摘要： The invention concerns a power-assisted lock for doors, hatches hoods or hard tops of vehicles and the like. In addition to a known pivotal latch and a catch for a releasable engagement with the pivotal latch there is a control disc pivotally mounted in the housing of the lock. A manual or power actuated drive means is attached to the control disc for the closing and opening operation. The pivotal latch and the control disc have a drive connection providing for limited play. The arrangement together with the catch leads to a locking of the control disc before a closing operation and an unlocking of the control disc by turning the pivotal latch during the closing operation of the lock. The pivotal latch has the usual pre-lock position.

摘要翻译： 本发明涉及用于门，舱口罩或车辆的硬顶等的电动辅助锁。 除了已知的枢转闩锁和用于与枢转闩锁的可释放接合的卡扣之外，还存在枢转地安装在锁的壳体中的控制盘。 手动或动力驱动的驱动装置附接到控制盘用于关闭和打开操作。 枢转闩锁和控制盘具有提供有限游隙的驱动连接。 这种布置与卡扣一起导致在关闭操作之前锁定控制盘，并且通过在锁的关闭操作期间转动枢转闩锁来解锁控制盘。 枢转闩锁具有通常的预锁定位置。

公开(公告)号：US6146887A

公开(公告)日：2000-11-14

申请号：US123708

申请日：1998-07-28

申请人： Jurgen Schrader ,  Axel Godecke

发明人： Jurgen Schrader ,  Axel Godecke

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C12N9/00 ,  C12N9/02 ,  C12N15/85 ,  C12R1/91 ,  C12N15/00

CPC分类号： C12N9/0075 ,  A61K47/48776 ,  C12N15/85 ,  A61K38/00 ,  A61K48/00 ,  C12N2800/108 ,  C12N2830/42

摘要： A DNA expression vector is described which is characterized in that it comprises a DNA sequence that codes a protein which possesses the biological activity of nitrogen monoxide synthase (NOS) and eukaryotic regulation elements, wherein said eukaryotic regulation elements result in the expression of said DNA sequence in eukaryotic cells, as well as the use of the expression vector for treatment or prevention of vascular disorders.

摘要翻译： 描述了DNA表达载体，其特征在于其包含编码具有一氧化氮合酶（NOS）和真核调节元件的生物活性的蛋白质的DNA序列，其中所述真核调节元件导致所述DNA序列的表达 在真核细胞中，以及使用表达载体治疗或预防血管疾病。

公开(公告)号：US5338085A

公开(公告)日：1994-08-16

申请号：US64641

申请日：1993-05-21

申请人： Martin Guckel ,  Jurgen Schrader ,  Bernd Wilms

发明人： Martin Guckel ,  Jurgen Schrader ,  Bernd Wilms

IPC分类号： B60J7/12

CPC分类号： B60J7/1247 ,  B60J7/185

摘要： The invention relates to a folding top for motor vehicles, having a top frame which comprises lateral top supports and a rear hoop. The top has a storage position of the top in an associated top box, into which it can be lowered by folding back the upright top supports about a main axis. The top frame has an articulation, spaced relative to the main axis, of the lateral legs of the rear hoop on the frame members which are jointly moved via the top supports, whereby the rear hoop is displaced backwards relative to the main axis during the lowering process, and having a rearward widening of the top box behind the top box aperture into which the rear hoop projects when the top is lowered. In order that incorrect operation during manual lowering of the top should be reliably prevented, the top supports of the top are retained, when the rear hoop is upright, via locking devices which prevent their folding-back movement and whose locking action can be cancelled by an advance rearward pivoting movement of the rear hoop, the pivot angle of the advance being such that, when the top supports are subsequently folded back, contact-free dipping of the rear hoop through the top box aperture is guaranteed.

摘要翻译： 本发明涉及一种用于机动车辆的折叠顶部，其具有包括侧顶部支撑件和后箍的顶部框架。 顶部具有顶部在相关联的顶部箱中的存储位置，通过将竖起的顶部支撑件绕主轴折回而可以将其放置在其中。 顶部框架具有相对于主轴线间隔的后箍的侧支腿在框架构件上，该框架构件通过顶部支撑件共同移动，由此后退环节在下降期间相对于主轴线向后移位 过程，并且在顶部顶部被降低时后顶部顶部突出的顶部框孔后面具有向后的加宽。 为了可靠地防止在手动降低顶部期间的不正确的操作，当后箍垂直时，顶部的顶部支撑件通过锁定装置保持，防止其折回运动并且其锁定动作可以被取消 后箍的前进向后枢转运动，前进的枢转角度使得当顶部支撑件随后被折回时，保证后箍通过顶盒孔的无接触浸渍。