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公开(公告)号:US20130089562A1
公开(公告)日:2013-04-11
申请号:US13441753
申请日:2012-04-06
IPC分类号: A61K39/395 , C12N5/071 , A61P1/16
CPC分类号: C07K16/28 , A61K38/177 , A61K38/179 , A61K38/18 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/475 , C07K14/52 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2319/30 , C07K2319/32 , Y02A50/463
摘要: Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.
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2.
公开(公告)号:US09200071B2
公开(公告)日:2015-12-01
申请号:US13498560
申请日:2010-09-29
申请人: Christian W. Siebel
发明人: Christian W. Siebel
IPC分类号: C07K16/28 , A61K39/395 , A61K39/00
CPC分类号: C07K16/28 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/2866 , C07K2317/34 , C07K2317/73 , C07K2317/76
摘要: The present invention relates to methods of treating cancer in general, and leukemia in particular, using Notch1 and Notch3 antagonists singly or in combination. Compositions and methods for the treatment and diagnosis of Notch-associated cancers are also provided.
摘要翻译: 本发明涉及一般治疗癌症的方法,特别涉及使用Notch1和Notch3拮抗剂单独或组合使用的白血病。 还提供了用于治疗和诊断Notch相关癌症的组合物和方法。
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公开(公告)号:US08846871B2
公开(公告)日:2014-09-30
申请号:US12156590
申请日:2008-06-03
申请人: Christian W. Siebel , Yan Wu
发明人: Christian W. Siebel , Yan Wu
IPC分类号: C07K16/00 , C07K16/28 , C07K14/705 , C07K14/71 , A61K39/00
CPC分类号: C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50
摘要: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗Notch1NRR抗体,以及包含使用这些抗体的组合物。
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公开(公告)号:US20120328608A1
公开(公告)日:2012-12-27
申请号:US13498560
申请日:2010-09-29
申请人: Christian W. Siebel
发明人: Christian W. Siebel
IPC分类号: A61K39/395 , A61P35/02 , G01N33/574 , C07K16/28
CPC分类号: C07K16/28 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/2866 , C07K2317/34 , C07K2317/73 , C07K2317/76
摘要: The present invention relates to methods of treating cancer in general, and leukemia in particular, using Notch1 and Notch3 antagonists singly or in combination. Compositions and methods for the treatment and diagnosis of Notch-associated cancers are also provided.
摘要翻译: 本发明涉及一般治疗癌症的方法,特别涉及使用Notch1和Notch3拮抗剂单独或组合使用的白血病。 还提供了用于治疗和诊断Notch相关癌症的组合物和方法。
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公开(公告)号:US09663573B2
公开(公告)日:2017-05-30
申请号:US14349005
申请日:2012-04-06
IPC分类号: A61K39/395 , A61P1/16 , C07K16/28 , C07K14/705 , C07K14/715 , C07K14/71 , A61K39/00
CPC分类号: C07K16/28 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要: Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.
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公开(公告)号:US20090081238A1
公开(公告)日:2009-03-26
申请号:US12156590
申请日:2008-06-03
申请人: Christian W. Siebel , Yan Wu
发明人: Christian W. Siebel , Yan Wu
IPC分类号: A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , A61P25/00 , A61P31/00 , C12N5/06 , C12P21/04
CPC分类号: C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50
摘要: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗Notch1NRR抗体,以及包含使用这些抗体的组合物。
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7.
公开(公告)号:US20150064186A1
公开(公告)日:2015-03-05
申请号:US14349005
申请日:2012-04-06
IPC分类号: C07K16/28
CPC分类号: C07K16/28 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要: Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.
摘要翻译: 提供了用于治疗肝脏病症的方法和组合物,所述方法和组合物包含Notch2拮抗剂,例如抗Notch2抗体。 肝病包括但不限于慢性肝病。
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公开(公告)号:US20100080808A1
公开(公告)日:2010-04-01
申请号:US12570267
申请日:2009-09-30
申请人: Christian W. Siebel , Yan Wu
发明人: Christian W. Siebel , Yan Wu
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
摘要翻译: 本发明提供抗Notch抗体,特别是结合Notch2 NRR的抗体及其使用方法。
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公开(公告)号:US08404239B2
公开(公告)日:2013-03-26
申请号:US12570267
申请日:2009-09-30
申请人: Christian W. Siebel , Yan Wu
发明人: Christian W. Siebel , Yan Wu
IPC分类号: A61K39/395 , C07K16/28 , C07K14/705
CPC分类号: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
摘要翻译: 本发明提供抗Notch抗体,特别是结合Notch2 NRR的抗体及其使用方法。
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