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公开(公告)号：US5604204A
公开(公告)日：1997-02-18
申请号：US395939
申请日：1995-02-27
IPC分类号： A61F2/28 , A61F2/30 , A61K35/28 , A61K35/32 , A61K38/18 , A61L27/22 , A61K38/00 , C12N15/00 , C07K14/00
CPC分类号： A61L27/227 , A61F2/28 , A61K35/28 , A61K38/1841 , A61F2002/2817 , A61F2002/30677 , A61L2430/02 , Y10S514/90
摘要： A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF-.beta. and a source of osteogenic cells in a pharmaceutically acceptable carrier.
摘要翻译： 提供了一种用于在骨骼组织缺乏的动物部位产生骨的方法，包括在成骨细胞源的存在下在骨部位局部给予动物，有效量的包含TGF-β的组合物 在药学上可接受的载体中，条件是该组合物不包括骨形态发生辅因子，所述组合物以有效诱导骨部位骨生长的量施用。 还提供了用于植入到骨骼组织缺乏的动物部位中的装置，其包括用有效量的包含TGF-β的组合物和在药学上可接受的载体中的成骨细胞来源处理的装置。
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2.发明授权Biologically active peptides structurally related to regions within growth hormones 失效生物活性肽结构上与生长激素内的区域有关
公开(公告)号：US4699897A
公开(公告)日：1987-10-13
申请号：US501024
申请日：1983-06-04
IPC分类号： C07K5/08 , A61K38/00 , A61K38/27 , A61K38/28 , A61P3/08 , A61P5/00 , C07K5/10 , C07K5/107 , C07K7/06 , C07K7/08 , C07K14/575 , C07K14/61 , A61K37/26
CPC分类号： C07K14/61 , C07K5/1016 , A61K38/00 , Y10S930/12
摘要： Disclosed are novel synthetic peptides having primary structural homology to a continuous sequence of amino acid residues of human growth hormone in a region spanning positions thirty-two to forty-six ("hGH.sub.32-46 ", or "deletion peptide"). In preferred forms, peptides of the invention comprehend: duplicate portions (i.e., sequence fragments) of hGH.sub.32-46 ; stereochemical analogs and fragment analogs of hGH.sub.32-46 including one or more amino acid residues in D-isomeric configuration; and, "interspecies" analogs and fragment analogs of hGH.sub.32-46 including one or more non-homologous amino acid residues duplicating variant residues present in corresponding positions in corresponding regions of heterologous species growth hormones. Peptides of the invention are administered to mammals contemporaneously with exogenous insulin to generate hypoglycemic effects greater than available through administration of insulin alone. A presently preferred heptapeptide has the sequence, NH.sub.2 -Glu-Glu-Ala-Tyr-Ile-Pro-Lys-COOH, and has insulin-potentiating activity greater than hGH.sub.32-46.
摘要翻译： 公开了在跨越位置32至46位（“hGH32-46”或“缺失肽”）的区域中与人生长激素的氨基酸残基的连续序列具有初级结构同源性的新型合成肽。 在优选形式中，本发明的肽包括hGH32-46的重复部分（即序列片段）; hGH32-46的立体化学类似物和片段类似物包括D-异构体构型中的一个或多个氨基酸残基; 以及hGH32-46的“种间”类似物和片段类似物，包括一个或多个重复存在于异源物种生长激素相应区域中相应位置的变体残基的非同源氨基酸残基。 将本发明的肽与外源性胰岛素同时施用于哺乳动物，以产生比通过单独施用胰岛素可获得的降血糖作用更大的降血糖作用。 目前优选的七肽具有序列NH2-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-COOH，并且具有大于hGH32-46的胰岛素增强活性。
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公开(公告)号：US4558033A
公开(公告)日：1985-12-10
申请号：US501023
申请日：1983-06-06
CPC分类号： C07K14/61 , A61K38/00 , Y10S930/12
摘要： Disclosed are novel methods and materials for developing hypoglycemic effects in mammals, including human. A pentadecapeptide ("deletion peptide") having the sequence, NH.sub.2 -Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-COOH, is administered to the mammal contemporaneously with exogenous insulin to generate hypoglycemic effects greater than available through administration of insulin alone. The pentadecapeptide sequence is duplicative of the sequence of amino acid residues in human growth hormone in the region spanning positions thirty-two through forty-six.
摘要翻译： 公开了用于在哺乳动物（包括人）中发展降血糖作用的新颖方法和材料。 将具有序列NH2-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-COOH的十五肽（“缺失肽”）施用于 哺乳动物与外源胰岛素同时产生比通过单独施用胰岛素可获得的降血糖作用更大的降血糖作用。 十五肽序列与跨越32位至46位的人类生长激素氨基酸残基序列重复。
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公开(公告)号：US4241051A
公开(公告)日：1980-12-23
申请号：US955608
申请日：1978-10-30
IPC分类号： A61K38/23 , A61K47/18 , A61K47/20 , A61K37/00 , C07C103/52
CPC分类号： A61K9/0014 , A61K38/23 , A61K47/18 , A61K47/20 , Y10S514/808
摘要： A method for the treatment of pathological processes in bone and connective tissue comprises the topical application of calcitonin to effect control of said processes by transepithelial action. Preferred compositions for use in the method are ear drops comprising an aprotic solvent or an aqueous medium containing a surface active agent.
摘要翻译： 用于治疗骨和结缔组织中的病理过程的方法包括局部应用降钙素以通过跨上皮作用来控制所述过程。 用于该方法的优选组合物是包含非质子溶剂或含有表面活性剂的水性介质的耳滴。
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公开(公告)号：US5409896A
公开(公告)日：1995-04-25
申请号：US132405
申请日：1993-11-12
IPC分类号： A61F2/28 , A61F2/30 , A61K35/28 , A61K35/32 , A61K38/18 , A61L27/22 , C12N15/00 , C07K13/00 , A61K37/02
CPC分类号： A61L27/227 , A61F2/28 , A61K35/28 , A61K38/1841 , A61F2002/2817 , A61F2002/30677 , A61L2430/02 , Y10S514/90
摘要： A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF-.beta. and a source of osteogenic cells in a pharmaceutically acceptable carrier.
摘要翻译： 提供了一种用于在骨骼组织缺乏的动物部位产生骨的方法，包括在成骨细胞源的存在下在骨部位局部给予动物，有效量的包含TGF-β的组合物 在药学上可接受的载体中，条件是该组合物不包括骨形态发生辅因子，所述组合物以有效诱导骨部位骨生长的量施用。 还提供了用于植入到骨骼组织缺乏的动物部位中的装置，其包括用有效量的包含TGF-β的组合物和在药学上可接受的载体中的成骨细胞来源处理的装置。
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公开(公告)号：US5422340A
公开(公告)日：1995-06-06
申请号：US255844
申请日：1994-06-08
申请人： Arthur J. Ammann , Steven L. Beck , Tue H. Nguyen , Boonsri Ongpipattanakul , Christopher G. Rudman
发明人： Arthur J. Ammann , Steven L. Beck , Tue H. Nguyen , Boonsri Ongpipattanakul , Christopher G. Rudman
CPC分类号： A61L27/227 , A61F2/28 , A61K35/28 , A61K38/1841 , A61F2002/2817 , A61F2002/30677 , A61L2430/02
摘要： A formulation suitable for inducing bone formation contains about 0.5 .mu.g to about 5 mg of transforming growth factor-.beta. and about 140 mg to about 50 g of tricalcium phosphate and excludes a bone morphogenetic cofactor. In another embodiment, the formulation contains about 0.5 .mu.g to 5 mg transforming growth factor-.beta., about 140 mg to 50 g of tricalcium phosphate particles, and an amount of amylopectin ranging from about 01:1 to 1:1 amylopectin:tricalcium phosphate.
摘要翻译： 适于诱导骨形成的制剂含有约0.5μg至约5mg的转化生长因子-β和约140mg至约50g磷酸三钙，并且不包括骨形态发生辅因子。 在另一个实施方案中，制剂含有约0.5μg至5mg转化生长因子-β，约140mg至50g磷酸三钙颗粒，以及支链淀粉的量为约0.01:1至1:1支链淀粉：磷酸三钙 。
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7.发明授权Method of restoring normal growth, weight gain or lean body mass in patients with glucocorticoid excess by administering IGF-I 失效恢复正常生长，重量增加或降低身体质量的方法通过管理IGF-I来治疗患有葡萄糖过多的患者
公开(公告)号：US5128320A
公开(公告)日：1992-07-07
申请号：US466899
申请日：1990-01-18
IPC分类号： A61K38/30
CPC分类号： A61K38/30
摘要： A method is disclosed for at least partially restoring normal growth, weight gain, and lean body mass of a mammal afflicted with glucocorticoid excess. This method comprises the administration to the mammal of an effective amount of IGF-I. Preferably, the mammal is a child and the IGF-I is native-sequence or brain IGF-I.
摘要翻译： 公开了一种至少部分恢复患有糖皮质激素过量的哺乳动物的正常生长，体重增加和瘦体重的方法。 该方法包括向哺乳动物施用有效量的IGF-1。 优选地，哺乳动物是小孩，IGF-I是天然序列或脑IGF-I。
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公开(公告)号：US5158934A
公开(公告)日：1992-10-27
申请号：US401906
申请日：1989-09-01
CPC分类号： A61L27/227 , A61F2/28 , A61K35/28 , A61K38/1841 , A61F2002/2817 , A61F2002/30677 , A61L2430/02 , Y10S514/90
摘要： A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF-.beta. and a source of osteogenic cells in a pharmaceutically acceptable carrier.
摘要翻译： 提供了一种用于在骨骼组织缺乏的动物部位产生骨的方法，包括在成骨细胞源的存在下在骨部位局部给予动物，有效量的包含TGF-β的组合物 在药学上可接受的载体中，条件是该组合物不包括骨形态发生辅因子，所述组合物以有效诱导骨部位骨生长的量施用。 还提供了用于植入到骨骼组织缺乏的动物部位中的装置，其包括用有效量的包含TGF-β的组合物和在药学上可接受的载体中的成骨细胞来源处理的装置。
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