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    Compositions magnetic particles covered with gem-bisphosphonate derivatives
    1.
    发明授权
    Compositions magnetic particles covered with gem-bisphosphonate derivatives 有权
    组合物用双 - 二膦酸衍生物覆盖的磁性颗粒

    公开(公告)号：US07780953B2

    公开(公告)日：2010-08-24

    申请号：US10739400

    申请日：2003-12-19

    申请人： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

    发明人： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

    IPC分类号： A61B5/055 ,  A61B5/05 ,  A01N57/18

    CPC分类号： B82Y5/00 ,  A61K49/1842

    摘要： The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2  (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates, also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

    摘要翻译： 本发明涉及一种组合物，其包含基于铁化合物的酸性磁性颗粒（p），酸性磁性颗粒（p）由一种或多种式偕二膦酸盐化合物络合：式I：XL-CH（PO 3 H 2）2 ）其中：L表示连接X基团与偕 - 双膦酸基团-CH（PO3H2）2的有机基团; X表示能够与生物载体反应的化学基团; 所有或一些X组的颗粒任选地与生物载体偶联。 本发明还涉及制备组合物及其用途的方法，特别是用于磁共振成像（MRI）的对比产物。

    Complex folate-NOTA-Ga68
    2.
    发明授权
    Complex folate-NOTA-Ga68 有权
    复合叶酸NOTA-Ga68

    公开(公告)号：US08986650B2

    公开(公告)日：2015-03-24

    申请号：US13205352

    申请日：2011-08-08

    申请人： Marc Port ,  Claire Corot ,  Thierry Gautheret

    发明人： Marc Port ,  Claire Corot ,  Thierry Gautheret

    IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  C07D209/48 ,  C07D239/95 ,  C07D295/15 ,  C07D487/04

    CPC分类号： A61K51/0459 ,  C07D209/48 ,  C07D239/95 ,  C07D295/15 ,  C07D487/04

    摘要： The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor, 2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof 3) LINKER is a chemical group linking FOLATE and NOTA 4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68.

    摘要翻译： 本发明涉及式FOLATE-（LINKER）i-NOTA-Ga68的Ga68复合物，其中：1）FOLATE是能够靶向叶酸受体的叶酸化合物或其衍生物，2）NOTA是能够络合Ga68的螯合物 具有NOTA支架或其衍生物3）LINKER是连接FOLATE和NOTA的化学基团4）i是选自0和1之间的整数，其中NOTA与Ga68络合。

    COMPLEX FOLATE-NOTA-Ga68
    3.
    发明申请
    COMPLEX FOLATE-NOTA-Ga68 有权
    复合FOLATE-NOTA-Ga68

    公开(公告)号：US20120064003A1

    公开(公告)日：2012-03-15

    申请号：US13205352

    申请日：2011-08-08

    申请人： Marc PORT ,  Claire COROT ,  Thierry GAUTHERET

    发明人： Marc PORT ,  Claire COROT ,  Thierry GAUTHERET

    IPC分类号： A61K51/08 ,  A61P35/00 ,  C07D255/00 ,  C07F5/00

    CPC分类号： A61K51/0459 ,  C07D209/48 ,  C07D239/95 ,  C07D295/15 ,  C07D487/04

    摘要： The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor, 2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof 3) LINKER is a chemical group linking FOLATE and NOTA 4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68

    摘要翻译： 本发明涉及式FOLATE-（LINKER）i-NOTA-Ga68的Ga68复合物，其中：1）FOLATE是能够靶向叶酸受体的叶酸化合物或其衍生物，2）NOTA是能够络合Ga68的螯合物 具有NOTA支架或其衍生物3）LINKER是连接FOLATE和NOTA的化学基团4）i是选自0和1之间的整数，其中NOTA络合Ga68

    Process for preparing a pharmaceutical formulation of contrast agents
    4.
    发明申请
    Process for preparing a pharmaceutical formulation of contrast agents 审中-公开
    制备造影剂药物制剂的方法

    公开(公告)号：US20090208421A1

    公开(公告)日：2009-08-20

    申请号：US12155997

    申请日：2008-06-12

    申请人： Dominique Meyer ,  Claire Corot

    发明人： Dominique Meyer ,  Claire Corot

    IPC分类号： A61K49/10

    CPC分类号： A61K49/108 ,  A61K9/0019 ,  A61K31/28 ,  A61K45/06 ,  A61K47/18 ,  A61K49/106 ,  G01N33/15

    摘要： The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.25%, the macrocyclic chelate advantageously being chosen from DOTA, NOTA, DOTAGA, DO3A, BT-DO3A, HP-DO3A and PCTA, and is preferably DOTA, the said process comprising the following successive steps: a) determination of a theoretical target concentration of free macrocyclic chelate Ctcl in the final liquid pharmaceutical formulation; b) preparation of a liquid pharmaceutical composition containing, firstly, the complex of macrocyclic chelate with a lanthanide, and, secondly, free macrocyclic chelate and/or free lanthanide; c) measurement in the pharmaceutical formulation obtained in step b) of the concentration of free macrocyclic chelate Ccl and/or of free lanthanide Cll; d) adjustment of Ccl and/or of Cll so as to obtain Ccl=Ctcl and Cll=0.

    摘要翻译： 本发明涉及制备含有大环螯合物与镧系元素络合物和摩尔/摩尔量的游离大环螯合物的液体药物制剂的方法，其含量为0.002％至0.4％，有利地为0.02％至0.3％，非常有利地介于 0.025％和0.25％，大环螯合物有利地选自DOTA，NOTA，DOTAGA，DO3A，BT-DO3A，HP-DO3A和PCTA，并且优选为DOTA，所述方法包括以下连续步骤：a） 最终液体药物制剂中游离大环螯合物Ctcl的理论目标浓度; b）制备液体药物组合物，其首先包含大环螯合物与镧系元素的复合物，其次，游离的大环螯合物和/或游离的镧系元素; c）在步骤b）中获得的药物制剂中游离大环螯合物Ccl和/或游离镧​​系元素C11的浓度的测量; d）调整Ccl和/或Cll，以获得Ccl = Ctcl和Cll = 0。

    Novel compositions magnetic particles covered with gem-bisphosphonate derivatives
    6.
    发明申请
    Novel compositions magnetic particles covered with gem-bisphosphonate derivatives 审中-公开
    新颖的组合物磁性颗粒被宝石二膦酸盐衍生物覆盖

    公开(公告)号：US20100297025A1

    公开(公告)日：2010-11-25

    申请号：US12801980

    申请日：2010-07-06

    申请人： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

    发明人： Marc Port ,  Claire Corot ,  Isabelle Raynal ,  Olivier Rousseaux

    IPC分类号： A61K49/10

    CPC分类号： B82Y5/00 ,  A61K49/1842

    摘要： The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO3H2)2   (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

    摘要翻译： 本发明涉及一种组合物，其包含基于铁化合物的酸性磁性颗粒（p），酸性磁性颗粒（p）由一种或多种式偕二膦酸盐化合物络合：式I：XL-CH（PO 3 H 2）2 ）其中：L表示连接X基团与偕 - 双膦酸基团-CH（PO3H2）2的有机基团; X表示能够与生物载体反应的化学基团; 所有或一些X组的颗粒任选地与生物载体偶联。 本发明还涉及制备组合物及其用途的方法，特别是作为磁共振成像（MRI）的对比产品。

    Water Diffusion imaging and Uspio
    10.
    发明申请
    Water Diffusion imaging and Uspio 审中-公开
    水扩散成像和Uspio

    公开(公告)号：US20090299172A1

    公开(公告)日：2009-12-03

    申请号：US12308089

    申请日：2007-06-06

    申请人： Claire Corot ,  Marc Port ,  Philippe Robert ,  Michel Schaefer ,  Denis Le Bihan ,  Johannes M. Fröhlich

    发明人： Claire Corot ,  Marc Port ,  Philippe Robert ,  Michel Schaefer ,  Denis Le Bihan ,  Johannes M. Fröhlich

    IPC分类号： A61B5/055

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/56341

    摘要： The invention relates to a method of water diffusion imaging in magnetic resonance imaging in an area of diagnostic interest, characterized in that it comprises, in combination, the administration of a contrast product capable of generating a signal specifically in its specific location area, said location area being included in said area of interest, the application of a water diffusion imaging sequence to the whole area of interest, and the reading of the images in the area of interest, the specific signal due to the contrast product significantly and specifically modifying the signal in the specific location area relative to the signal of the whole area of interest.

    摘要翻译： 本发明涉及一种在诊断感兴趣区域的磁共振成像中的水扩散成像方法，其特征在于，其组合包括能够特异地在其特定位置区域中产生信号的造影剂的施用，所述位置 包括在所述感兴趣区域中的区域，将水扩散成像序列应用于感兴趣的整个区域，以及在感兴趣区域中读取图像，由于对比度产物引起的特定信号显着地并且具体地修改信号 在相对于感兴趣的整个区域的信号的特定位置区域。