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    MICROBIAL PRODUCTION OF L-ASCORBIC ACID
    2.
    发明申请
    MICROBIAL PRODUCTION OF L-ASCORBIC ACID 有权
    L-抗坏血酸的微生物生产

    公开(公告)号：US20100203598A1

    公开(公告)日：2010-08-12

    申请号：US12701748

    申请日：2010-02-08

    申请人： ALAN BERRY ,  CONNIE LEE ,  ANNE FRANCOISE MAYER ,  MASAKO SHINJOH

    发明人： ALAN BERRY ,  CONNIE LEE ,  ANNE FRANCOISE MAYER ,  MASAKO SHINJOH

    IPC分类号： C12P17/04

    CPC分类号： C12P17/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12P7/60

    摘要： The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps.

    摘要翻译： 本发明公开了衍生自编码具有L-山梨糖酮脱氢酶活性的多肽的多核苷酸的分离的多核苷酸分子，其包含SEQ ID NO：1的至少20个连续核苷酸的部分核苷酸序列。 本发明还涉及以高产率生产L-抗坏血酸的方法，特别是使用能够将给定碳源转化成维生素C的微生物的静息细胞的方法。由此获得的维生素C可以进一步由 纯化和/或分离步骤。

    Novel Gene STS 22
    3.
    发明申请
    Novel Gene STS 22 审中-公开
    新基因STS 22

    公开(公告)号：US20090215135A1

    公开(公告)日：2009-08-27

    申请号：US11883542

    申请日：2006-02-10

    申请人： Marie-Gabrielle Beuzelin-Ollivier ,  Bastian Chevreux ,  Manuela Dalluege ,  Markus G. Goese ,  Connie Lee ,  Anja Meury ,  Nigel J. Mouncey ,  Masako Shinjoh

    发明人： Marie-Gabrielle Beuzelin-Ollivier ,  Bastian Chevreux ,  Manuela Dalluege ,  Markus G. Goese ,  Connie Lee ,  Anja Meury ,  Nigel J. Mouncey ,  Masako Shinjoh

    IPC分类号： C12P17/04 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  C07K14/705 ,  C12N15/87

    CPC分类号： C12N15/52

    摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

    摘要翻译： 本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。 本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。 本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或 所述微生物中发酵产物的生产效率。 还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。 本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

    BRUXISM SENSOR
    4.
    发明申请
    BRUXISM SENSOR 审中-公开
    BRUXISM传感器

    公开(公告)号：US20160228285A1

    公开(公告)日：2016-08-11

    申请号：US14618706

    申请日：2015-02-10

    申请人： EDDY H. DELRIO ,  CONNIE LEE DELRIO

    发明人： EDDY H. DELRIO ,  CONNIE LEE DELRIO

    IPC分类号： A61F5/56

    CPC分类号： A61F5/566 ,  A61B5/4557 ,  A61B5/6803 ,  A61B5/682 ,  A61B5/746 ,  A61B2562/0247 ,  A61F2005/563 ,  A61M16/049 ,  A61M2230/63

    摘要： A bruxism sensor includes a diaphragm switch which provides an electrical output including a diaphragm separating a pressure side having a pressure side inlet and a suction side having a suction side inlet. An audible alarm having an electrical input is coupled to the electrical output. A first hose has one end is fluidically coupled to the pressure side inlet and a biting configured opposite end (biting end) for positioning between teeth of a user. Wherein upon a contraction of a mandible of the user, the biting end is squeezed which generates air pressure that is applied to the pressure side to generate a pressure level sufficient for activating the diaphragm switch, and while the diaphragm switch is activated, the audible alarm automatically sounds an alarm for alerting the user of contraction of their mandible.

    摘要翻译： 磨牙传感器包括提供电输出的隔膜开关，该电气输出包括分隔压力侧的隔膜，压力侧具有压力侧入口和具有吸入侧入口的吸入侧。 具有电输入的声音报警器耦合到电输出。 第一软管的一端流体地联接到压力侧入口和咬合构造的相对端（咬端），用于在使用者的牙齿之间定位。 其中，在使用者的下颌骨收缩时，咬合端被挤压，其产生施加到压力侧的空气压力以产生足以启动隔膜开关的压力水平，并且当隔膜开关被启动时，声音报警器 自动发出警报，提醒用户收缩下颌骨。

    Microbial production of L-ascorbic acid
    5.
    发明授权
    Microbial production of L-ascorbic acid 有权
    微生物生产L-抗坏血酸

    公开(公告)号：US08338144B2

    公开(公告)日：2012-12-25

    申请号：US12701748

    申请日：2010-02-08

    申请人： Alan Berry ,  Connie Lee ,  Anne Françoise Mayer ,  Masako Shinjoh

    发明人： Alan Berry ,  Connie Lee ,  Anne Françoise Mayer ,  Masako Shinjoh

    IPC分类号： C12P17/04

    CPC分类号： C12P17/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12P7/60

    摘要： The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps.

    摘要翻译： 本发明公开了衍生自编码具有L-山梨糖酮脱氢酶活性的多肽的多核苷酸的分离的多核苷酸分子，其包含SEQ ID NO：1的至少20个连续核苷酸的部分核苷酸序列。 本发明还涉及以高产率生产L-抗坏血酸的方法，特别是使用能够将给定碳源转化成维生素C的微生物的静息细胞的方法。由此获得的维生素C可以进一步由 纯化和/或分离步骤。

    Polypeptides and encoding polynucleotides for microbial production of L-ascorbic acid and associated methods
    8.
    发明授权
    Polypeptides and encoding polynucleotides for microbial production of L-ascorbic acid and associated methods 有权
    用于微生物生产L-抗坏血酸的多肽和编码多核苷酸及相关方法

    公开(公告)号：US07700723B2

    公开(公告)日：2010-04-20

    申请号：US10567763

    申请日：2004-08-16

    申请人： Alan Berry ,  Connie Lee ,  Anne Françoise Mayer ,  Masako Shinjoh

    发明人： Alan Berry ,  Connie Lee ,  Anne Françoise Mayer ,  Masako Shinjoh

    IPC分类号： C07K1/00

    CPC分类号： C12P17/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12P7/60

    摘要： The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps.

    摘要翻译： 本发明公开了衍生自编码具有L-山梨糖酮脱氢酶活性的多肽的多核苷酸的分离的多核苷酸分子，其包含SEQ ID NO：1的至少20个连续核苷酸的部分核苷酸序列。 本发明还涉及以高产率生产L-抗坏血酸的方法，特别是使用能够将给定碳源转化成维生素C的微生物的静息细胞的方法。由此获得的维生素C可以进一步由 纯化和/或分离步骤。

    Bruxism sensor
    10.
    发明授权
    Bruxism sensor 有权
    磨牙传感器

    公开(公告)号：US09398974B1

    公开(公告)日：2016-07-26

    申请号：US14618706

    申请日：2015-02-10

    申请人： Eddy H. DelRio ,  Connie Lee DelRio

    发明人： Eddy H. DelRio ,  Connie Lee DelRio

    IPC分类号： A61F5/56

    CPC分类号： A61F5/566 ,  A61B5/4557 ,  A61B5/6803 ,  A61B5/682 ,  A61B5/746 ,  A61B2562/0247 ,  A61F2005/563 ,  A61M16/049 ,  A61M2230/63

    摘要： A bruxism sensor includes a diaphragm switch which provides an electrical output including a diaphragm separating a pressure side having a pressure side inlet and a suction side having a suction side inlet. An audible alarm having an electrical input is coupled to the electrical output. A first hose has one end is fluidically coupled to the pressure side inlet and a biting configured opposite end (biting end) for positioning between teeth of a user. Wherein upon a contraction of a mandible of the user, the biting end is squeezed which generates air pressure that is applied to the pressure side to generate a pressure level sufficient for activating the diaphragm switch, and while the diaphragm switch is activated, the audible alarm automatically sounds an alarm for alerting the user of contraction of their mandible.

    摘要翻译： 磨牙传感器包括提供电输出的隔膜开关，该电气输出包括分隔压力侧的隔膜，压力侧具有压力侧入口和具有吸入侧入口的吸入侧。 具有电输入的声音报警器耦合到电输出。 第一软管的一端流体地联接到压力侧入口和咬合构造的相对端（咬端），用于在使用者的牙齿之间定位。 其中，在使用者的下颌骨收缩时，咬合端被挤压，其产生施加到压力侧的空气压力以产生足以启动隔膜开关的压力水平，并且当隔膜开关被启动时，声音报警器 自动发出警报，提醒用户收缩下颌骨。