公开(公告)号：US08101189B2

公开(公告)日：2012-01-24

申请号：US11556678

申请日：2006-11-03

申请人： Denis Leclerc ,  Nathalie Majeau ,  Constantino III Roberto Lopez-Macias ,  Alain Lamarre

发明人： Denis Leclerc ,  Nathalie Majeau ,  Constantino III Roberto Lopez-Macias ,  Alain Lamarre

IPC分类号： A61K35/00 ,  C12N15/00

CPC分类号： A61K39/12 ,  A61K39/02 ,  A61K2039/5258 ,  A61K2039/55555 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/62 ,  C07K2319/00 ,  C07K2319/21 ,  C12N7/00 ,  C12N2760/10122 ,  C12N2770/24222 ,  C12N2770/26022 ,  C12N2770/26023

摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.

摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。