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1.发明授权Vaccines and immunopotentiating compositions and methods for making and using them 有权疫苗和免疫增强组合物和制备和使用它们的方法公开(公告)号：US08101189B2
公开(公告)日：2012-01-24
申请号：US11556678
申请日：2006-11-03
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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公开(公告)号：US07641896B2
公开(公告)日：2010-01-05
申请号：US10609417
申请日：2003-07-01
IPC分类号： A61K35/00
CPC分类号： A61K39/39 , A61K39/385 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/26023 , Y02A50/484
摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen-carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
摘要翻译： 本发明涉及具有免疫增强或佐剂性质的免疫原载体。 更具体地，免疫原载体是来自虫病毒病毒的病毒样颗粒（VLP），最特别是木瓜花叶病毒。 通过重组技术产生的VLP与其自身蛋白质之一融合蛋白免疫原。 上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可以用作疫苗。
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公开(公告)号：US20050048082A1
公开(公告)日：2005-03-03
申请号：US10609417
申请日：2003-07-01
CPC分类号： A61K39/39 , A61K39/385 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/26023 , Y02A50/484
摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen—carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
摘要翻译： 本发明涉及具有免疫增强或佐剂性质的免疫原载体。 更具体地，免疫原载体是来自虫病毒病毒的病毒样颗粒（VLP），最特别是木瓜花叶病毒。 通过重组技术产生的VLP与其自身蛋白质之一融合蛋白免疫原。 上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可以用作疫苗。
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4.发明申请VACCINES AND IMMUNOPOTENTIATING COMPOSITIONS AND METHODS FOR MAKING AND USING THEM 审中-公开疫苗和免疫组合物及其制备和使用方法公开(公告)号：US20140134202A1
公开(公告)日：2014-05-15
申请号：US13324887
申请日：2011-12-13
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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5.发明授权Vaccines and immunopotentiating compositions and methods for making and using them 有权疫苗和免疫增强组合物和制备和使用它们的方法公开(公告)号：US09339535B2
公开(公告)日：2016-05-17
申请号：US13324887
申请日：2011-12-13
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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公开(公告)号：US20070166322A1
公开(公告)日：2007-07-19
申请号：US11556678
申请日：2006-11-03
申请人： Denis Leclerc , Nathalie Majeau , Philippe Tessier , Constantino III Lopez-Macias , Alain Lamarre , Rejean Lapointe
发明人： Denis Leclerc , Nathalie Majeau , Philippe Tessier , Constantino III Lopez-Macias , Alain Lamarre , Rejean Lapointe
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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