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公开(公告)号：US11998594B2
公开(公告)日：2024-06-04
申请号：US17039312
申请日：2020-09-30
IPC分类号： A61K39/00 , A61K39/295 , A61K39/39 , A61P35/00 , C07K14/005 , C12N7/00
CPC分类号： A61K39/001106 , A61K39/0011 , C07K14/005 , C12N7/00 , A61K2039/5258 , A61K2039/54 , A61K2039/542 , C12N2770/26023 , C12N2770/26043 , C12N2770/26071
摘要： An anti-cancer virus composition including an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen is described. The anti-cancer virus composition can be used for methods of treating or decreasing the risk of developing a HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the anti-cancer virus composition.
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2.发明申请公开(公告)号：US20130236491A1
公开(公告)日：2013-09-12
申请号：US13877306
申请日：2011-02-15
申请人： Iosif Grigorievich Atabekov , Olga Viacheslavovna Karpova , Mikhail Petrovich Kirpichnikov , Nikolay Alexandrovich Nikitin , Sergey Nikolaevich Chirkov , Ekaterina Alexeevna Trifonova , Anna Alexandrovna Sheveleva , Marina Vladimirovna Archipenko
发明人： Iosif Grigorievich Atabekov , Olga Viacheslavovna Karpova , Mikhail Petrovich Kirpichnikov , Nikolay Alexandrovich Nikitin , Sergey Nikolaevich Chirkov , Ekaterina Alexeevna Trifonova , Anna Alexandrovna Sheveleva , Marina Vladimirovna Archipenko
CPC分类号： C07K14/08 , A61K39/12 , A61K39/145 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , B82Y5/00 , C07K14/005 , C07K17/00 , C07K2319/20 , C07K2319/21 , C12N2760/16134 , C12N2770/26022 , C12N2770/26023 , C12N2770/26042 , C12N2770/26062 , C12N2770/34034 , C12N2770/36234 , C12N2770/40022 , C12N2770/40042 , C12N2770/40062
摘要： A novel type of particle platform for application in biotechnology is provided by the present invention. Said platforms comprise RNA-free particles generated by thermal denaturation and structural remodeling of helical plant viruses. Tobamovir-uses and, in particular, tobacco mosaic virus (TMV) coat protein (CP) subunits, denatured, at high temperatures are specifically self-assembled by two-stage assembly into the spherical particles (SPs) of similar shape and varying size including nanoparticles (SNPs) with a diameter up to 100-150 nm and spherical microparticles (SMPs) with a diameter up to 800 nm and more. The size of said SPs depends on the virus concentration used and, therefore can be controlled. Said SPs are biologically safe, highly stable and highly immunogenic. Said SNPs and SMPs are structurally distinct from viruses presently known. They are unique, having no protein nano-particle analogs in the nature. Said particles can be produced by the native virus and also by different forms of viral CP lacking RNA. The SPs can be generated by thermal denaturation and structural remodeling of different helical plant viruses belonging to genera Tobamovirus, Hordeivirus and family Flexiviridae. The invention relates to the creation of functionally active compostions on the base of said SP-platforms for use in medicine, veterinary, virology, immunology and diagnostics.In accordance with this aspect of the present invention, several immunogenic compositions were obtained comprising SP platform and linked to the SP surface foreign full-size proteins, including green fluorescent protein, coat protein of PVX or epitopes of several different viruses (e.g. human influenza A virus and rubella virus epitopes). The procedure of in vitro assembly of said type of composition took about one hour. Apparently, the nanocomplexes of SNP/SMP with foreign antigens/epitopes could be regarded as candidate nanovaccines. In accordance with another aspect of the present invention, we found that the TMV-generated SPs can be used as immunological booster or adjuvant stimulating the immune response of animals by parenteral immunization.
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3.发明申请公开(公告)号：US20170021003A1
公开(公告)日：2017-01-26
申请号：US15300931
申请日：2015-04-02
IPC分类号： A61K39/00 , C12N7/00 , C07K14/005
CPC分类号： A61K39/0011 , A61K2039/5258 , A61K2039/54 , A61K2039/542 , C07K14/005 , C12N7/00 , C12N2770/26023 , C12N2770/26043 , C12N2770/26071
摘要： A vaccine composition including a plant virus particle linked to an HER2 antigen is described. The vaccine composition can be used for methods of treating or preventing an HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the vaccine composition.
摘要翻译： 描述了包含与HER2抗原连接的植物病毒颗粒的疫苗组合物。 疫苗组合物可用于通过向有需要的受试者施用有效量的疫苗组合物来治疗或预防受试者中HER2表达的癌症的方法。
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4.发明申请PAPAYA MOSAIC VIRUS COMPOSITIONS AND USES THEREOF FOR STIMULATION OF THE INNATE IMMUNE RESPONSE 审中-公开PAPAYA MOSAIC VIRUS组合物及其用于刺激免疫应答的用途公开(公告)号：US20140154288A1
公开(公告)日：2014-06-05
申请号：US14117363
申请日：2012-05-01
申请人： Denis Leclerc , Alain Lamarre
发明人： Denis Leclerc , Alain Lamarre
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K39/39 , C12N2760/10011 , C12N2760/16111 , C12N2770/26023 , C12N2770/26034 , C12N2770/26042 , Y02A50/403 , Y02A50/407 , Y02A50/478
摘要： The use of compositions comprising a papaya mosaic virus (PapMV) moiety for stimulation of the innate immune response is provided. The PapMV moiety may be papaya mosaic virus or PapMV virus-like particles (VLPs). The PapMV compositions stimulate a sufficiently strong innate immune response to provide protection against subsequent pathogen challenge or to treat an established infection. The use of PapMV compositions to protect a subject from potential infection by a pathogen, such as a viral pathogen, a bacterial pathogen or a fungal pathogen, and the use of PapMV compositions to treat an established infection, are also provided. The PapMV compositions be administered, for example, via intranasal or pulmonary routes to elicit effects within the mucosa and/or in the respiratory system.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）部分的组合物用于刺激先天免疫应答的用途。 PapMV部分可以是番木瓜花叶病毒或PapMV病毒样颗粒（VLP）。 PapMV组合物刺激足够强的先天免疫应答以提供针对随后的病原体攻击的保护或治疗已建立的感染。 还提供了使用PapMV组合物来保护受试者免受病原体（例如病毒病原体，细菌病原体或真菌病原体）的潜在感染，以及使用PapMV组合物治疗已建立的感染。 PapMV组合物例如通过鼻内或肺部途径施用以在粘膜和/或呼吸系统内引发作用。
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公开(公告)号：US20110206727A1
公开(公告)日：2011-08-25
申请号：US13056962
申请日：2009-05-15
申请人： Denis Leclerc
发明人： Denis Leclerc
IPC分类号： A61K39/295 , A61P37/04 , A61P31/16
CPC分类号： A61K39/0275 , A61K2039/523 , A61K2039/5258 , A61K2039/545 , A61K2039/55516 , A61K2039/70 , C12N2760/16111 , C12N2760/16211 , C12N2770/26023 , Y02A50/482 , Y02A50/484
摘要： A multivalent vaccine composition that comprises a papaya mosaic virus (PapMV) component and one or more antigens is provided. The composition can further optionally comprise a Salmonella spp. porin component. The PapMV component can be PapMV or PapMV virus-like particles (VLPs). The porin component can be a Salmonella spp. OmpC, OmpF or a combination thereof, and can be combined with the PapMV component or conjugated to the PapMV component. The PapMV component in the multivalent vaccine composition functions as an adjuvant and/or an immunostimulant with respect to the one or more antigens. Use of the multivalent vaccine compositions to provide protection against a plurality of strains of a pathogen, or against more than one pathogen, are also provided.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）组分和一种或多种抗原的多价疫苗组合物。 组合物还可以任选地包含沙门氏菌属。 孔蛋白成分。 PapMV组分可以是PapMV或PapMV病毒样颗粒（VLP）。 孔蛋白组分可以是沙门氏菌属。 OmpC，OmpF或其组合，并且可以与PapMV组分组合或与PapMV组分缀合。 多价疫苗组合物中的PapMV组分用作一种或多种抗原的佐剂和/或免疫刺激剂。 还提供了使用多价疫苗组合物来提供针对多种病原体菌株或针对多于一种病原体的保护。
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6.发明申请RECOMBINANT PAPAYA MOSAIC VIRUS COAT PROTEINS AND USES THEREOF IN INFLUENZA VACCINES 审中-公开重组PAPAYA MOSAIC VIRUS COAT蛋白及其在流感疫苗中的应用公开(公告)号：US20150056231A1
公开(公告)日：2015-02-26
申请号：US14388810
申请日：2013-02-19
申请人： FOLIA BIOTECH INC.
发明人： Denis Leclerc , Nathalie Majeau
IPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , A61K39/145
CPC分类号： C07K14/005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55516 , A61K2039/55577 , A61K2039/6075 , A61K2039/6081 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2770/26023 , C12N2770/26034 , C12N2770/26043 , C12N2770/40034 , Y02A50/482
摘要： Recombinant papaya mosaic virus (PapMV) coat proteins comprising one or more antigenic peptides derived from an influenza virus antigen, such as from the M2e peptide, fused at a position within a predicted random coil within 13 amino acids of the N-terminus of the coat protein, uses thereof to prepare virus-like particles (VLPs), and uses of the VLPs in influenza vaccines.
摘要翻译： 包含一种或多种衍生自流感病毒抗原的抗原肽（例如来自M2e肽）的重组番木瓜花叶病毒（PapMV）外壳蛋白在外壳的N末端的13个氨基酸内的预测的无规卷曲内的位置融合 蛋白质，其用于制备病毒样颗粒（VLP）的用途以及VLPs在流感疫苗中的用途。
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7.发明授权Vaccines and immunopotentiating compositions and methods for making and using them 有权疫苗和免疫增强组合物和制备和使用它们的方法公开(公告)号：US08101189B2
公开(公告)日：2012-01-24
申请号：US11556678
申请日：2006-11-03
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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公开(公告)号：US07641896B2
公开(公告)日：2010-01-05
申请号：US10609417
申请日：2003-07-01
IPC分类号： A61K35/00
CPC分类号： A61K39/39 , A61K39/385 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/26023 , Y02A50/484
摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen-carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
摘要翻译： 本发明涉及具有免疫增强或佐剂性质的免疫原载体。 更具体地，免疫原载体是来自虫病毒病毒的病毒样颗粒（VLP），最特别是木瓜花叶病毒。 通过重组技术产生的VLP与其自身蛋白质之一融合蛋白免疫原。 上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可以用作疫苗。
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公开(公告)号：US20050048082A1
公开(公告)日：2005-03-03
申请号：US10609417
申请日：2003-07-01
CPC分类号： A61K39/39 , A61K39/385 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/26023 , Y02A50/484
摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen—carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
摘要翻译： 本发明涉及具有免疫增强或佐剂性质的免疫原载体。 更具体地，免疫原载体是来自虫病毒病毒的病毒样颗粒（VLP），最特别是木瓜花叶病毒。 通过重组技术产生的VLP与其自身蛋白质之一融合蛋白免疫原。 上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可以用作疫苗。
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公开(公告)号：US12070478B2
公开(公告)日：2024-08-27
申请号：US18115066
申请日：2023-02-28
发明人： Nicole F. Steinmetz , Karin L. Lee
CPC分类号： A61K35/76 , A61K31/704 , A61K39/12 , A61K39/39 , A61P35/00 , A61K45/06 , C12N2770/26011 , C12N2770/26023 , C12N2770/26033 , C12N2770/26042 , C12N2770/40023
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
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