公开(公告)号：US4962029A

公开(公告)日：1990-10-09

申请号：US437311

申请日：1989-11-16

Applicant: Corey Levenson ,  Chu-an Chang ,  Fred T. Oakes

Inventor： Corey Levenson ,  Chu-an Chang ,  Fred T. Oakes

IPC: C07H21/00

CPC classification number: C07H21/00 ,  Y10S435/964

Abstract: Oligonucleotides derivatized to incorporate horseradish peroxidase (HRP) are useful in diagnostic methods and provide significant advantage over radioactively labeled oligonucleotide probes. The HRP-derivatized oligonucleotides can be easily and efficiently prepared by reacting a sulfhydryl containing oligonucleotide with a conjugate of a mal-sac-HNSA ester and HRP under mild and easily controlled reaction conditions.

Abstract translation: 衍生成掺入辣根过氧化物酶（HRP）的寡核苷酸可用于诊断方法，并且比放射性标记的寡核苷酸探针提供显着的优点。 通过在温和且容易控制的反应条件下使含巯基的寡核苷酸与mal-sac-HNSA酯和HRP的缀合物反应，可以容易且有效地制备HRP衍生的寡核苷酸。

公开(公告)号：US20130005830A1

公开(公告)日：2013-01-03

申请号：US13582133

申请日：2011-03-01

Applicant: Ian Clements ,  Paul Castella ,  Corey Levenson

Inventor： Ian Clements ,  Paul Castella ,  Corey Levenson

IPC: A61K31/045 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K36/185 ,  A61K2300/00

Abstract: Provided herein are compositions of sandalwood oil and methods of making and using such compositions.

Abstract translation: 本文提供檀香油的组合物和制备和使用这些组合物的方法。

公开(公告)号：US06602910B2

公开(公告)日：2003-08-05

申请号：US09801197

申请日：2001-03-06

Applicant: Corey Levenson ,  Ze'ev Shaked

Inventor： Corey Levenson ,  Ze'ev Shaked

IPC: A61K31195

CPC classification number: A61K31/195 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/905 ,  Y10S977/907

Abstract: The present invention concerns a method for preventing and/or treating cancer in a patient comprising administering an effective amount of substantially purified D enantiomer of difluoromethylornithine (D-DFMO) or an analog of D-DFMO to the patient. D-DFMO or an analog thereof is administered at a dose of about 0.05 to about 20.0 gm/M2/day. D-DFMO or an analog thereof may be administered more than once for the treatment and/or prevention of cancer. Methods of administration as well as compositions and formulations of substantially purified D-DFMO and analogs of D-DFMO are described.

公开(公告)号：US20140154342A1

公开(公告)日：2014-06-05

申请号：US14235387

申请日：2012-07-27

Applicant: Ian Clements ,  Paul Castella ,  Corey Levenson

Inventor： Ian Clements ,  Paul Castella ,  Corey Levenson

IPC: A61K36/185

CPC classification number: A61K36/185 ,  A61K8/0212 ,  A61K8/922 ,  A61K9/0014 ,  A61K31/19 ,  A61K31/194 ,  A61K31/60 ,  A61K33/04 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  A61Q9/02 ,  A61Q19/00 ,  A61Q19/10 ,  A61K2300/00

Abstract: Provided herein are compositions of sandalwood heartwood oil and methods of making and using such compositions.

Abstract translation: 本文提供了檀香心材油的组合物以及制备和使用这些组合物的方法。

公开(公告)号：US4914210A

公开(公告)日：1990-04-03

申请号：US104200

申请日：1987-10-02

Applicant: Corey Levenson ,  Chu-An Chang ,  Fred T. Oakes

Inventor： Corey Levenson ,  Chu-An Chang ,  Fred T. Oakes

IPC: C07C43/11 ,  C07C43/178 ,  C07C323/12 ,  C07D209/48 ,  C07D317/22 ,  C07F9/24 ,  C07F9/26 ,  C07F9/48 ,  C07F9/553 ,  C07H21/00 ,  C07H21/04 ,  C08G65/335 ,  C12Q1/68 ,  G01N33/535

CPC classification number: C07D209/48 ,  C07C323/12 ,  C07C43/11 ,  C07C43/178 ,  C07D317/22 ,  C07F9/2408 ,  C07F9/2441 ,  C07F9/2458 ,  C07F9/2487 ,  C07F9/26 ,  C07F9/5537 ,  C07H21/00 ,  C08G65/3356 ,  C12Q1/6816 ,  G01N33/535

Abstract: Oligonucleotide functionalizing reagents are disclosed which are useful in introducing sulfhydryl, amino and additional hydroxyl groups into oligonucleotides. The reagents are substantially linear in structure, at one end provided with a phosphoramidite moiety, at an opposing end provided with a sulfhydryl, amino or hydroxyl moiety, the two ends linked through a hydrophilic spacer chain. Methods of using and synthesizing the novel reagents are disclosed as well.

Abstract translation: 公开了寡核苷酸官能化试剂，其用于将巯基，氨基和另外的羟基引入寡核苷酸。 试剂在结构上基本上是线性的，在一端具有亚磷酰胺部分，在相对端具有巯基，氨基或羟基部分，两个末端通过亲水间隔链连接。 还公开了使用和合成新试剂的方法。