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    Modular Functional Peptides for the Intracellular Delivery of Nanoparticles
    6.
    发明申请
    Modular Functional Peptides for the Intracellular Delivery of Nanoparticles 有权
    用于纳米颗粒细胞内递送的模块化功能肽

    公开(公告)号：US20110097797A1

    公开(公告)日：2011-04-28

    申请号：US12908601

    申请日：2010-10-20

    Applicant: James B. Delehanty ,  Igor L. Medintz ,  Hedi M. Mattoussi ,  Glyn Dawson ,  Philip E. Dawson ,  Juan Bautista Blanco-Canosa ,  Kelly Boeneman

    Inventor： James B. Delehanty ,  Igor L. Medintz ,  Hedi M. Mattoussi ,  Glyn Dawson ,  Philip E. Dawson ,  Juan Bautista Blanco-Canosa ,  Kelly Boeneman

    IPC: C12N5/071 ,  C07K2/00 ,  C07H21/00 ,  B82Y5/00

    CPC classification number: C07H21/04 ,  A61K47/6921 ,  A61K49/0093 ,  B82Y5/00 ,  C07H19/00

    Abstract: Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and the uptake and vesicle escape domains, and wherein the peptide, when attached to an extracellular nanoparticle, is effective to induce uptake of the nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.

    Abstract translation: 描述了用于将纳米颗粒递送到细胞溶质的肽，所述肽包含：（a）纳米颗粒缔合结构域; （b）富含脯氨酸的间隔区; （c）摄取域; 和（d）包含不可水解脂质部分的囊泡逃逸结构域，其中所述间隔区位于纳米颗粒缔合结构域和吸收和囊泡逃逸结构域之间，并且其中当连接到细胞外纳米颗粒时，该肽有效诱导 通过细胞摄取纳米颗粒并将纳米颗粒递送到细胞的胞质溶胶。 还描述了将纳米颗粒递送到细胞的细胞溶质的方法，该方法包括向细胞提供与这种肽连接的纳米颗粒。 示例性纳米颗粒包括量子点。

    Apparatus for protecting a vehicle from scratches and animal hair caused by and shed respectively from a pet
    8.
    发明申请
    Apparatus for protecting a vehicle from scratches and animal hair caused by and shed respectively from a pet 审中-公开
    用于保护车辆免受由宠物引起和流出的划痕和动物毛发的装置

    公开(公告)号：US20070006810A1

    公开(公告)日：2007-01-11

    申请号：US11474753

    申请日：2006-06-26

    Applicant: Danielle Dawson ,  Richard Dawson

    Inventor： Danielle Dawson ,  Richard Dawson

    IPC: A01K39/00

    CPC classification number: A01K1/035 ,  A01K1/0272

    Abstract: An apparatus for protecting a vehicle from a pet scratching and shedding hair includes a first member having each of a first predetermined shape, a first predetermined size, a first predetermined thickness and which is substantially impermeable to such pet's nails. The first member extends over such vehicle's window ledge and downwardly a predetermined distance from such vehicle window ledge which is at least sufficient to prevent such pet's nails contacting such vehicle's paint. There is a second member having each of a second predetermined shape, a second predetermined size and a second predetermined thickness for preventing at least one of such pet's hair and wet and muddy paws from contacting a seat of such vehicle. A securing device is engageable with a first predetermined edge of the first member and a first predetermined edge of the second member for securing such first member to such second member.

    Abstract translation: 一种用于保护车辆免受宠物刮毛和脱毛的设备包括具有第一预定形状，第一预定尺寸，第一预定厚度以及这种宠物指甲基本上不可渗透的每一个的第一构件。 第一个构件在这种车辆的窗台上延伸并向下延伸至该车辆窗台的预定距离，该至少足以防止该宠物的指甲接触该车辆的油漆。 存在具有第二预定形状，第二预定尺寸和第二预定厚度中的每一个的第二构件，用于防止这种宠物的头发和湿和泥泞的爪子中的至少一个与这种车辆的座位接触。 固定装置可与第一构件的第一预定边缘和第二构件的第一预定边缘接合，用于将该第一构件固定到该第二构件。

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