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公开(公告)号：US20140004041A1
公开(公告)日：2014-01-02
申请号：US14002021
申请日：2012-03-02
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K51/088
摘要： The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
摘要翻译： 本发明涉及包含适于体内SPECT或PET成像的放射性标记的c-Met结合肽的锝显像剂。 c-Met结合肽通过螯合剂缀合物标记。 还公开了药物组合物，制剂的制备方法和组合物，以及使用该组合物的体内成像方法，特别是用于诊断癌症的方法。
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公开(公告)号：US08304388B2
公开(公告)日：2012-11-06
申请号：US12302290
申请日：2007-05-25
申请人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
发明人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
CPC分类号： A61K51/088 , A61K49/0002
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.
摘要翻译： 本发明提供了适用于纤维化的非侵入性可视化的新型成像剂。 本发明还提供了用于制备显影剂的前体，以及包含显影剂和用于制备药物组合物的试剂盒的药物组合物。 在另一方面，提供了用于体内成像和用于诊断包括纤维化的病症的药物的制备的成像剂的用途。
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公开(公告)号：US20080279769A1
公开(公告)日：2008-11-13
申请号：US11575977
申请日：2005-09-23
申请人： Magne Solbakken , Alan Cuthbertson , Anthony Eamon Storey , Alexander Jackson , Sally-Ann Ricketts , Peter Brian Iveson
发明人： Magne Solbakken , Alan Cuthbertson , Anthony Eamon Storey , Alexander Jackson , Sally-Ann Ricketts , Peter Brian Iveson
IPC分类号： A61K51/04 , C07C233/47 , C07D209/20 , A61K31/404 , A61K31/16
CPC分类号： A61K49/10 , A61K49/085 , A61K51/0497
摘要： The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.
摘要翻译： 本发明公开了包含用成像部分标记的异羟肟酸酯类型的特定类型的基质金属蛋白酶抑制剂（MMPi）的成像剂是用于哺乳动物身体的体内成像和诊断的有用的诊断显像剂。
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公开(公告)号：US20110286922A1
公开(公告)日：2011-11-24
申请号：US13124703
申请日：2009-10-20
IPC分类号： A61K51/04 , C07C223/02 , C07C47/55 , C07C235/84 , C07C47/575 , C07C311/39 , C07D217/26 , C07D215/48 , C07D215/42 , C07D215/36 , C07F5/02 , C07D209/12 , C07D209/42 , A61P35/00 , A61K49/00
CPC分类号： A61K51/04 , A61K51/0446 , A61K51/0455 , A61K51/0478 , A61K51/0482
摘要： The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer.
摘要翻译： 本发明涉及靶向酶醛脱氢酶（ALDH）并适用于体内成像肿瘤和治疗癌症的体内成像和放射治疗方法和试剂。
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公开(公告)号：US20110280803A1
公开(公告)日：2011-11-17
申请号：US13145136
申请日：2010-01-29
申请人： Michelle Avory , Jane Brown , Peter Brian Iveson
发明人： Michelle Avory , Jane Brown , Peter Brian Iveson
IPC分类号： A61K51/04 , C07C231/02 , B65D85/00 , C07C259/06 , A61P43/00 , C07D213/77 , C07D213/64
CPC分类号： A61K51/0406 , A61K51/0402 , A61K51/0455 , C07C241/04 , C07D213/77 , C07F7/2208 , C07C243/32
摘要： The present invention provides a method for the synthesis of radioiodinated compounds which is advantageous over prior art methods. Using a hydrazine or an aminoxy in place of a primary amine for indirect radioiodination facilitates a much quicker reaction thus reducing reaction time and increasing the yield. In addition, where there are primary amines in the molecule to be radioiodinated, such as the N-terminus of a peptide or lysine residues, reaction at the hydrazine or aminoxy is greatly favoured.
摘要翻译： 本发明提供了一种合成放射性碘化合物的方法，其优于现有技术方法。 使用肼或氨氧基代替伯胺进行间接放射性碘化有利于快速反应，从而减少反应时间并提高产率。 此外，如果在分子中存在要放射性碘化的伯胺，例如肽或赖氨酸残基的N末端，则肼或氨氧基的反应是非常有利的。
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公开(公告)号：US09259496B2
公开(公告)日：2016-02-16
申请号：US14002021
申请日：2012-03-02
CPC分类号： A61K51/08 , A61K51/088
摘要： The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
摘要翻译： 本发明涉及包含适于体内SPECT或PET成像的放射性标记的c-Met结合肽的锝显像剂。 c-Met结合肽通过螯合剂缀合物标记。 还公开了药物组合物，制剂的制备方法和组合物，以及使用该组合物的体内成像方法，特别是用于诊断癌症的方法。
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公开(公告)号：US20130149241A1
公开(公告)日：2013-06-13
申请号：US13816589
申请日：2011-08-11
CPC分类号： A61K49/00 , A61K38/16 , A61K38/1833 , A61K51/088 , C07K7/64
摘要： The present invention relates to imaging agent compositions comprising radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. The c-Met binding peptides are labelled with the radioisotope 18F. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the management of cancer.
摘要翻译： 本发明涉及包含适用于体内正电子发射断层摄影（PET）成像的放射性标记的c-Met结合肽的成像剂组合物。 c-Met结合肽用放射性同位素18F标记。 还公开了药物组合物，制剂的制备方法和组合物，以及使用该组合物的体内成像方法，特别是用于治疗癌症的方法。
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公开(公告)号：US20120165650A1
公开(公告)日：2012-06-28
申请号：US12975425
申请日：2010-12-22
申请人： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Eriksson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
发明人： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Eriksson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
CPC分类号： A61K51/088 , C07K14/71
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译： 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。
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公开(公告)号：US09533059B2
公开(公告)日：2017-01-03
申请号：US13816589
申请日：2011-08-11
CPC分类号： A61K49/00 , A61K38/16 , A61K38/1833 , A61K51/088 , C07K7/64
摘要： The present invention relates to imaging agent compositions comprising radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. The c-Met binding peptides are labelled with the radioisotope 18F. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the management of cancer.
摘要翻译： 本发明涉及包含适用于体内正电子发射断层摄影（PET）成像的放射性标记的c-Met结合肽的成像剂组合物。 c-Met结合肽用放射性同位素18F标记。 还公开了药物组合物，制剂的制备方法和组合物，以及使用该组合物的体内成像方法，特别是用于治疗癌症的方法。
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公开(公告)号：US20090191123A1
公开(公告)日：2009-07-30
申请号：US12302290
申请日：2007-05-25
申请人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
发明人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
CPC分类号： A61K51/088 , A61K49/0002
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.
摘要翻译： 本发明提供了适用于纤维化的非侵入性可视化的新型成像剂。 本发明还提供了用于制备显影剂的前体，以及包含显影剂和用于制备药物组合物的试剂盒的药物组合物。 在另一方面，提供了用于体内成像和用于诊断包括纤维化的病症的药物的制备的成像剂的用途。
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