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    IMPROVED TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT
    3.
    发明申请
    IMPROVED TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT 审中-公开
    改进的交叉机构功能测量

    公开(公告)号：US20160249808A1

    公开(公告)日：2016-09-01

    申请号：US15030727

    申请日：2014-10-20

    申请人： Ralf HEINRICH ,  Johannes PILL ,  Sabine NEUDECKER ,  Daniel SCHOCK-KUSCH ,  Jurgen GUNTHER ,  Stefan KONIG ,  Jochen FRIEDMANN

    发明人： Ralf HEINRICH ,  Johannes PILL ,  Sabine NEUDECKER ,  Daniel SCHOCK-KUSCH ,  Jurgen GUNTHER ,  Stefan KONIG ,  Jochen FRIEDMANN

    IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/20

    CPC分类号： A61B5/0071 ,  A61B5/1455 ,  A61B5/201

    摘要： The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

    摘要翻译： 本发明涉及一种用于确定受试者的器官功能的方法，包括以下步骤：提供通过在至少一个第一时间点的第一位置背景荧光的体液中经皮测量而获得的第一浓度 - 时间曲线，以及 在至少第二，第三，第四，第五和第六时间点的指示剂化合物的荧光; 提供通过在至少八分之一，九分之一，十分之一，十一分之一和十二分之一的至少七个时间点内的第二位置背景荧光体液测量和指示剂化合物的荧光获得的第二浓度曲线 时间点; 将第一和第二浓度曲线拟合成代表至少四个扩散室的动力学模型; 从而确定受试者的器官功能。 本发明还涉及根据本发明的方法确定器官功能的装置，所述装置包括用于经皮测量第一位置上的指示器的荧光的第一传感器，用于经皮测量指示器的荧光的第二传感器 第二个位置 以及数据处理单元，用于将由所述传感器获得的值拟合到前述权利要求之一的动力学模型中。 本发明还涉及包括本发明的装置和指示剂化合物的试剂盒以及包括至少一种处理器的计算机或计算机网络，其中计算机或计算机网络适于执行根据本发明的方法 本发明。