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1.发明授权Nucleic acids encoding receptor for IL-17 homologous polypeptides and therapeutic uses thereof 有权编码IL-17同源多肽的受体的核酸及其治疗用途公开(公告)号：US08338132B2
公开(公告)日：2012-12-25
申请号：US12412796
申请日：2009-03-27
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： C12N15/09
CPC分类号： C07K14/54 , A61K38/00 , C07K14/7155 , C07K2319/30 , C12N2510/00 , G01N33/6869 , G01N2500/04 , G01N2800/24
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20100041138A1
公开(公告)日：2010-02-18
申请号：US11976813
申请日：2007-10-29
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
CPC分类号： C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20090269844A1
公开(公告)日：2009-10-29
申请号：US10458573
申请日：2003-06-10
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
CPC分类号： C07K14/54 , A61K38/00 , C07K14/7155 , C07K2319/30 , C12N2510/00 , G01N33/6869 , G01N2500/04 , G01N2800/24
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20060204493A1
公开(公告)日：2006-09-14
申请号：US11218286
申请日：2005-09-01
申请人： Arthur Huang , Barbara Moffat , Daniel Yansura
发明人： Arthur Huang , Barbara Moffat , Daniel Yansura
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/44 , C12N5/06
CPC分类号： C07K16/283 , C07K16/00 , C07K2317/24 , C07K2317/31 , C07K2317/53
摘要： The invention provides heteromultimeric antibodies, and methods of making these antibodies at high yields and purity. The invention also provides methods and compositions for using these antibodies.
摘要翻译： 本发明提供异源多聚体抗体，以及以高产率和纯度制备这些抗体的方法。 本发明还提供了使用这些抗体的方法和组合物。
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公开(公告)号：US20060134755A1
公开(公告)日：2006-06-22
申请号：US11311554
申请日：2005-12-20
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
CPC分类号： C07K14/54
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060088917A1
公开(公告)日：2006-04-27
申请号：US11311561
申请日：2005-12-20
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
CPC分类号： C07K14/54
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07829684B2
公开(公告)日：2010-11-09
申请号：US12541828
申请日：2009-08-14
申请人： James A. Ernst , Daniel Yansura , Hok Seon Kim
发明人： James A. Ernst , Daniel Yansura , Hok Seon Kim
CPC分类号： C07K14/70535 , C07K14/245 , C07K14/70596 , C07K16/2887 , C07K16/2896 , C07K2317/34 , C07K2317/55 , C07K2317/92 , C12N15/70 , C12P21/02
摘要： Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
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公开(公告)号：US07655783B2
公开(公告)日：2010-02-02
申请号：US11438487
申请日：2006-05-22
申请人： Dorothea Reilly , Daniel Yansura
发明人： Dorothea Reilly , Daniel Yansura
CPC分类号： C07K16/2896 , C07K16/22 , C07K16/4291 , C07K2317/24 , C07K2317/53 , C07K2319/00 , C07K2319/30
摘要： The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
摘要翻译： 本发明提供用于改善宿主细胞表达系统中重组抗体表达和产生的方法和组合物。 特别地，提供了具有修饰的铰链半胱氨酸残基的抗原的原核表达和产生。 本发明还提供了用于本发明的实践方法的组合物，试剂盒和制品。
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公开(公告)号：US20070128111A1
公开(公告)日：2007-06-07
申请号：US11438487
申请日：2006-05-22
申请人： Dorothea Reilly , Daniel Yansura
发明人： Dorothea Reilly , Daniel Yansura
CPC分类号： C07K16/2896 , C07K16/22 , C07K16/4291 , C07K2317/24 , C07K2317/53 , C07K2319/00 , C07K2319/30
摘要： The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
摘要翻译： 本发明提供用于改善宿主细胞表达系统中重组抗体表达和产生的方法和组合物。 特别地，提供了具有修饰的铰链半胱氨酸残基的抗原的原核表达和产生。 本发明还提供了用于本发明的实践方法的组合物，试剂盒和制品。
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公开(公告)号：US20060088916A1
公开(公告)日：2006-04-27
申请号：US11311555
申请日：2005-12-20
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
CPC分类号： C07K14/54
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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