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8 条记录 (耗时 0.015 秒)

    On-line free space defragmentation of a contiguous-file file system
    1.
    发明授权
    On-line free space defragmentation of a contiguous-file file system 失效
    连续文件文件系统的在线可用空间碎片整理

    公开(公告)号：US6070172A

    公开(公告)日：2000-05-30

    申请号：US813811

    申请日：1997-03-06

    申请人： David A. Lowe

    发明人： David A. Lowe

    IPC分类号： G06F3/06 ,  G06F17/30

    CPC分类号： G06F17/30135 ,  G06F3/0608 ,  G06F3/0643 ,  G06F3/0644 ,  G06F3/0676 ,  Y10S707/99956

    摘要： A file system configuration is scored by summing the squares of the sizes of each contiguous section of free space. A set of defragmentation plans, each describing a sequence of file movements, is generated and scored. The defragmentation plan with the highest score is chosen and executed. In moving a file, a temporary file of the same size is created and the file is copied to the temporary file. After the copying, the temporary file is designated as the file, and the file system space originally occupied by the file is unallocated.

    摘要翻译： 通过对可用空间的每个连续部分的大小的平方求和来对文件系统配置进行加和。 生成一组碎片整理计划，每个都会描述一系列文件移动，并进行打分。 选择并执行具有最高分数的碎片整理计划。 在移动文件时，会创建一个相同大小的临时文件，并将该文件复制到临时文件中。 复制后，临时文件被指定为该文件，文件系统空间最初由文件占用未分配。

    Modular building system
    3.
    发明授权
    Modular building system 失效
    模块化建筑系统

    公开(公告)号：US3559357A

    公开(公告)日：1971-02-02

    申请号：US3559357D

    申请日：1969-07-09

    申请人： DAVID A LOWE

    发明人： LOWE DAVID A

    IPC分类号： E04B1/18 ,  E04B2/56 ,  E04B1/08 ,  E04B1/48

    CPC分类号： E04B1/18 ,  E04B2/56 ,  Y10T403/46

    摘要： A MODULAR BUILDING SYSTEM IS PROVIDED WHICH INCLUDES EXTRUDED STRUCTURAL FRAMING FORMED OF METAL OR PLASTIC, IN WHICH THE INDIVIDUAL TUBULAR MEMBERS HAVE RECTANGULAR MULTILATERAL CONFIGURATION, AND MAY BE QUICKLY AND CONVENIENTLY INTERCONNECTED WITH ONE ANOTHER AND WITH OTHER STRUCTURAL ELEMENTS IN A SNAP ENGAGEMENT OR BY STRUCTURAL PINS. THE RESULTING STRUCTURE IS A LOW COST MODULAR BUILDING SYSTEM, ACCOMMODATING INDIVIDUAL PARTS AS REMOVABLE, RELOCATABLE, REPLACEABLE, AND ADDITIVE, AS REQUIRED, FOR TECHNOLOGICAL MASS PRODUCTION, AND EASY TRANSPORTATION AND ASSEMBLY.

    METHODS AND COMPOSITIONS FOR THE PROTECTION OF SENSORY CELLS
    4.
    发明申请
    METHODS AND COMPOSITIONS FOR THE PROTECTION OF SENSORY CELLS 审中-公开
    用于保护感染细胞的方法和组合物

    公开(公告)号：US20170072015A1

    公开(公告)日：2017-03-16

    申请号：US15123238

    申请日：2015-03-03

    申请人： Lawrence M. Schwartz ,  Gerald Commissiong ,  David A. Lowe ,  Roman Urfer

    发明人： Lawrence M. Schwartz ,  Gerald Commissiong ,  David A. Lowe ,  Roman Urfer

    IPC分类号： A61K38/18

    CPC分类号： A61K38/185

    摘要： Disclosed herein are methods of treating or preventing cell death-related sensory cell loss in a subject in need thereof, the method comprising administering an effective amount of one or more neuroprotective peptides to the subject. Also disclosed are methods of treating or preventing drug-induced ototoxicity in a subject in need thereof, the method comprising administering an effective amount of one or more neuroprotective peptides to the subject.

    摘要翻译： 本文公开了在有需要的受试者中治疗或预防细胞死亡相关的感觉细胞损失的方法，所述方法包括给受试者施用有效量的一种或多种神经保护肽。 还公开了在有需要的受试者中治疗或预防药物诱导的耳毒性的方法，所述方法包括向受试者施用有效量的一种或多种神经保护肽。

    Compounds for treatment of neurodegenerative diseases
    5.
    发明授权
    Compounds for treatment of neurodegenerative diseases 失效
    用于治疗神经变性疾病的化合物

    公开(公告)号：US07705017B2

    公开(公告)日：2010-04-27

    申请号：US11120502

    申请日：2005-05-03

    申请人： Christopher J. Cummings ,  David A. Lowe ,  William C. Ripka

    发明人： Christopher J. Cummings ,  David A. Lowe ,  William C. Ripka

    IPC分类号： A61K31/47 ,  C07D213/02

    CPC分类号： C07D217/02 ,  A61K31/47 ,  C07D217/06 ,  C07D217/08 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04

    摘要： The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.

    摘要翻译： 本发明涉及能抑制组蛋白脱乙酰酶（HDAC）的一类小分子异羟肟酸化合物。 本发明还涉及本发明的异羟肟酸HDAC抑制剂化合物的制备方法，它们是N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物，以及它们掺入药物组合物和给药方法中。 本发明还涉及可以用于本领域已知的筛选方法中的异羟肟酸HDAC抑制剂化合物文库的N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物。

    Kinetic Energy Rotation System
    8.
    发明申请
    Kinetic Energy Rotation System 审中-公开
    动能转动系统

    公开(公告)号：US20110156400A1

    公开(公告)日：2011-06-30

    申请号：US12651276

    申请日：2009-12-31

    申请人： David A. Lowe

    发明人： David A. Lowe

    IPC分类号： F03D9/00 ,  F03B17/04

    CPC分类号： F03G7/10 ,  F03D1/02 ,  F03D9/12 ,  F03D9/25 ,  F03D13/10 ,  F03D13/20 ,  Y02E10/72

    摘要： A kinetic energy rotation system is disclosed which comprises a plurality of wind powered generators. A motor rotates the wind powered generators in a horizontal plane and stores kinetic energy due to the rotating mass of the wind powered generators and its support platform. As electricity is generated by the wind powered generators, a portion of the generated electricity is fed back into the motor to maintain the rotation of the wind powered generators. Excess electricity may be redirected to the city's electrical grid, or other local electrical needs.

    摘要翻译： 公开了一种动能旋转系统，其包括多个风力发电机。 电机使风力发电机在水平面上旋转，并且由于风力发电机及其支撑平台的旋转质量而存储动能。 当风力发电机产生电力时，所产生的电力的一部分被反馈到电动机中以保持风力发电机的旋转。 过多的电力可能被重定向到城市的电网或其他本地电力需求。