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公开(公告)号：US07705017B2
公开(公告)日：2010-04-27
申请号：US11120502
申请日：2005-05-03
IPC分类号： A61K31/47 , C07D213/02
CPC分类号： C07D217/02 , A61K31/47 , C07D217/06 , C07D217/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.
摘要翻译： 本发明涉及能抑制组蛋白脱乙酰酶（HDAC）的一类小分子异羟肟酸化合物。 本发明还涉及本发明的异羟肟酸HDAC抑制剂化合物的制备方法，它们是N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物，以及它们掺入药物组合物和给药方法中。 本发明还涉及可以用于本领域已知的筛选方法中的异羟肟酸HDAC抑制剂化合物文库的N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物。
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公开(公告)号：US20110156400A1
公开(公告)日：2011-06-30
申请号：US12651276
申请日：2009-12-31
申请人： David A. Lowe
发明人： David A. Lowe
摘要： A kinetic energy rotation system is disclosed which comprises a plurality of wind powered generators. A motor rotates the wind powered generators in a horizontal plane and stores kinetic energy due to the rotating mass of the wind powered generators and its support platform. As electricity is generated by the wind powered generators, a portion of the generated electricity is fed back into the motor to maintain the rotation of the wind powered generators. Excess electricity may be redirected to the city's electrical grid, or other local electrical needs.
摘要翻译： 公开了一种动能旋转系统，其包括多个风力发电机。 电机使风力发电机在水平面上旋转，并且由于风力发电机及其支撑平台的旋转质量而存储动能。 当风力发电机产生电力时，所产生的电力的一部分被反馈到电动机中以保持风力发电机的旋转。 过多的电力可能被重定向到城市的电网或其他本地电力需求。
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公开(公告)号：US06800465B2
公开(公告)日：2004-10-05
申请号：US10114810
申请日：2002-04-03
申请人： Michael Politino , Sean M. Tonzi , Guna Romancik , John J. Usher , David A. Lowe
发明人： Michael Politino , Sean M. Tonzi , Guna Romancik , John J. Usher , David A. Lowe
IPC分类号： C12P1304
CPC分类号： C12N9/86 , C12Y305/02002
摘要： The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.
摘要翻译： 本发明涉及一种来自Ochrobactrum人参的新型D-乙内酰脲，其将对 - 乙内酰脲对选择性水解成其相应的D-N-氨基甲酰基 - 氨基酸; 编码酶的核酸; 包括核酸的表达载体; 和能够表达该酶的宿主细胞。
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公开(公告)号：US6070172A
公开(公告)日：2000-05-30
申请号：US813811
申请日：1997-03-06
申请人： David A. Lowe
发明人： David A. Lowe
CPC分类号： G06F17/30135 , G06F3/0608 , G06F3/0643 , G06F3/0644 , G06F3/0676 , Y10S707/99956
摘要： A file system configuration is scored by summing the squares of the sizes of each contiguous section of free space. A set of defragmentation plans, each describing a sequence of file movements, is generated and scored. The defragmentation plan with the highest score is chosen and executed. In moving a file, a temporary file of the same size is created and the file is copied to the temporary file. After the copying, the temporary file is designated as the file, and the file system space originally occupied by the file is unallocated.
摘要翻译： 通过对可用空间的每个连续部分的大小的平方求和来对文件系统配置进行加和。 生成一组碎片整理计划，每个都会描述一系列文件移动，并进行打分。 选择并执行具有最高分数的碎片整理计划。 在移动文件时，会创建一个相同大小的临时文件，并将该文件复制到临时文件中。 复制后，临时文件被指定为该文件，文件系统空间最初由文件占用未分配。
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公开(公告)号：US5512454A
公开(公告)日：1996-04-30
申请号：US191304
申请日：1994-02-03
申请人： John J. Usher , Guna Romancik , Michael Politino , David A. Lowe
发明人： John J. Usher , Guna Romancik , Michael Politino , David A. Lowe
CPC分类号： C12P35/00 , Y10S435/839 , Y10S435/911 , Y10S435/917
摘要： O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.
摘要翻译： O-酰化头孢菌素是通过使3-羟甲基头孢菌素与含有至少三个碳原子的酰基供体反应而得到的，以及一种酶，其为罗德孢菌属罗罗糖酯酯酶，小麦胚芽脂肪酶，黑曲霉脂肪酶，橙皮乙酰酯酶或枯草芽孢杆菌酯酶 。 优选的酶是来自Rodosporidium toruloides ATCC 10657的酯酶。该酶可以在全细胞中或以可溶或不溶形式使用。
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公开(公告)号：US20170072015A1
公开(公告)日：2017-03-16
申请号：US15123238
申请日：2015-03-03
IPC分类号： A61K38/18
CPC分类号： A61K38/185
摘要： Disclosed herein are methods of treating or preventing cell death-related sensory cell loss in a subject in need thereof, the method comprising administering an effective amount of one or more neuroprotective peptides to the subject. Also disclosed are methods of treating or preventing drug-induced ototoxicity in a subject in need thereof, the method comprising administering an effective amount of one or more neuroprotective peptides to the subject.
摘要翻译： 本文公开了在有需要的受试者中治疗或预防细胞死亡相关的感觉细胞损失的方法，所述方法包括给受试者施用有效量的一种或多种神经保护肽。 还公开了在有需要的受试者中治疗或预防药物诱导的耳毒性的方法，所述方法包括向受试者施用有效量的一种或多种神经保护肽。
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公开(公告)号：US4520101A
公开(公告)日：1985-05-28
申请号：US472444
申请日：1983-03-07
IPC分类号： C07D501/28 , C12P35/06 , C12R1/75 , C12N9/18
CPC分类号： C12P35/06
摘要： Production of undesired desacetylcephalosporin C during fermentation of cephalosporin C-producing microorganisms is substantially reduced by addition of certain phosphorous compounds to the culture medium.
摘要翻译： 通过向培养基中加入某些磷化合物，在产生头孢菌素C-产生微生物的发酵期间产生不期望的去乙酰头孢菌素C.
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