Abstract:
Nucleic acid constructs comprising hypoxia response elements in operable linkage with a coding sequence of a gene of interest, and methods for expressing a nucleic acid sequence using the constructs, are disclosed. In particular, such nucleic acid constructs comprise genes encoding prodrug activation systems or cytokines.
Abstract:
Nucleic acid constructs comprising hypoxia response elements in operable linkage with a coding sequence of a gene of interest are disclosed. In particular, such nucleic acid constructs comprise genes encoding pro-drug activation systems or cytokines.
Abstract:
A lanyard suspension system for a prosthetic limb that includes: (a) a lanyard cord adapted to extend from a distal end of a patient's residual limb; and (b) a lanyard lock assembly adapted to be seated at a distal end of a patient's prosthetic limb socket assembly. The lanyard lock assembly includes: (1) a lanyard lock base having a lanyard cord channel extending therethrough from an inlet hole in a proximal surface of the lanyard lock base to an outlet hole in one of a side surface and a distal surface of the lanyard lock base, where the lanyard cord channel is adapted to receive the lanyard cord extending therethrough; and (2) a locking mechanism designed to allow the lanyard cord to substantially freely thread through the lanyard cord channel from the inlet hole to the outlet hole while substantially inhibiting the lanyard cord to thread in the opposite direction when in an active setting and designed to allow the lanyard cord to freely thread through the lanyard cord channel in both directions when in an inactive setting. In this first aspect, the locking mechanism utilizes at least one biased jaw for engaging with the lanyard cord in the cord channel when the lanyard cord is pulled in the opposite direction in the active setting.
Abstract:
A lifting sling and a method for making the same are disclosed. The lifting sling comprises an elongated, flexible member having a working surface, a lifting end portion for attaching to a lifting mechanism and a choker end portion. A plurality of longitudinally spaced apart gripping members are attached to the working surface of the flexible member for frictionally engaging the outer surface of a load being lifted. To make the lifting sling, the flexible member is laid on the face of a mold having cavities for forming the gripping members. Liquid casting material is introduced into the mold cavities and allowed to penetrate the surface of the flexible member for permanent bonding thereto.