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    METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES
    1.
    发明申请
    METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES 有权
    用PSORALEN衍生物治疗细胞增殖障碍的方法和系统

    公开(公告)号：US20100266621A1

    公开(公告)日：2010-10-21

    申请号：US12763404

    申请日：2010-04-20

    申请人： Eric Toone ,  David Gooden ,  Tuan Vo-Dinh ,  Frederic A. Bourke, JR.

    发明人： Eric Toone ,  David Gooden ,  Tuan Vo-Dinh ,  Frederic A. Bourke, JR.

    IPC分类号： A61K39/00 ,  C07D405/14 ,  A61K31/4433 ,  A61K31/453 ,  C07D211/22 ,  C07D215/38 ,  A61K31/4709 ,  A61P35/00

    CPC分类号： C07D493/04 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4709 ,  A61K41/0066 ,  A61K45/06 ,  A61N5/062 ,  A61N5/10

    摘要： Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.

    摘要翻译： 式（I）的补骨脂素化合物：其中（N +芳基）是选自式（i） - （iii）的含氮芳族杂环的成员：其中Z是下式的基团：其中R是C1-C30 烃基，其可以是直链，支链或环状的并且含有1至15个碳 - 碳双键，其可以彼此共轭或非共轭或可以包括芳环，并且可以含有一个或多个取代基; R 1是氢，芳基，杂芳基，烷基，环烷基，杂环基，烯基，炔基，烯 - 芳基，烯 - 杂芳基，烯烃 - 杂环基，烯 - 环烷基，稠合环烷基芳基，稠合环烷基杂芳基，稠合杂环基芳基，稠合杂环杂芳基，亚烷基稠合环烷基芳基 亚烷基稠合的环烷基杂芳基，亚烷基稠合的杂环基芳基，亚烷基稠合的杂环杂芳基; n为1〜8的整数，X为药学上可接受的抗衡离子; 及其在治疗受试者的细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效应的方法。

    Methods and systems for treating cell proliferation disorders with psoralen derivatives
    6.
    发明授权
    Methods and systems for treating cell proliferation disorders with psoralen derivatives 有权
    用补骨脂素衍生物治疗细胞增殖障碍的方法和系统

    公开(公告)号：US08383836B2

    公开(公告)日：2013-02-26

    申请号：US12763404

    申请日：2010-04-20

    申请人： Eric Toone ,  David Gooden ,  Tuan Vo-Dinh ,  Frederic A. Bourke, Jr.

    发明人： Eric Toone ,  David Gooden ,  Tuan Vo-Dinh ,  Frederic A. Bourke, Jr.

    IPC分类号： C07D493/00 ,  C07D215/38 ,  C07D211/32

    CPC分类号： C07D493/04 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4709 ,  A61K41/0066 ,  A61K45/06 ,  A61N5/062 ,  A61N5/10

    摘要： Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.

    摘要翻译： 式（I）的补骨脂素化合物：其中（N +芳基）是选自式（i） - （iii）的含氮芳族杂环的成员：其中Z是下式的基团：其中R是C1-C30 烃基，其可以是直链，支链或环状的并且含有1至15个碳 - 碳双键，其可以彼此共轭或非共轭或可以包括芳环，并且可以含有一个或多个取代基; R 1是氢，芳基，杂芳基，烷基，环烷基，杂环基，烯基，炔基，烯 - 芳基，烯 - 杂芳基，烯烃 - 杂环基，烯 - 环烷基，稠合环烷基芳基，稠合环烷基杂芳基，稠合杂环基芳基，稠合杂环杂芳基，亚烷基稠合环烷基芳基 亚烷基稠合的环烷基杂芳基，亚烷基稠合的杂环基芳基，亚烷基稠合的杂环杂芳基; n为1〜8的整数，X为药学上可接受的抗衡离子; 及其在治疗受试者的细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效应的方法。