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    PREPARATION FOR ENDOVENOUS LASER ABLATION
    2.
    发明申请
    PREPARATION FOR ENDOVENOUS LASER ABLATION 有权
    内镜激光治疗的准备

    公开(公告)号：US20070123846A1

    公开(公告)日：2007-05-31

    申请号：US11562944

    申请日：2006-11-22

    申请人： David Hennings

    发明人： David Hennings

    IPC分类号： A61B18/18

    CPC分类号： A61B18/24 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/00196 ,  A61B2018/2261 ,  A61B2090/036 ,  A61F7/10 ,  A61F2007/101

    摘要： Improved devices and methods for removing blood from a blood vessel in preparation for endovenous laser ablation are described. The improved methods include one or more of: placing the patient in the Trendelenburg position, applying external compression around the vein, massaging the vein, cooling the vein externally, encouraging spasming of the vein, and removing blood with a suction device.

    摘要翻译： 描述了改进的用于从血管中移除血液的装置和方法，以准备静止的激光烧蚀。 改进的方法包括以下一个或多个：将患者置于Trendelenburg位置，在静脉周围施加外部压迫，按摩静脉，从外部冷却静脉，鼓励静脉静脉和用抽吸装置去除血液。

    Endovenous closure of varicose veins with mid infrared laser
    3.
    发明申请
    Endovenous closure of varicose veins with mid infrared laser 有权
    用中红外激光静脉闭合静脉曲张

    公开(公告)号：US20050131400A1

    公开(公告)日：2005-06-16

    申请号：US10982504

    申请日：2004-11-04

    申请人： David Hennings ,  Mitchel Goldman ,  Robert Weiss ,  Eric Taylor ,  Don Johnson ,  Ignacio Cespedes

    发明人： David Hennings ,  Mitchel Goldman ,  Robert Weiss ,  Eric Taylor ,  Don Johnson ,  Ignacio Cespedes

    IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61B18/20

    CPC分类号： A61B18/24 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/00196 ,  A61B2018/2261 ,  A61B2090/036

    摘要： This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 2.2 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308, or that may be provided with a protective spacer. A motorized pull back device 104 may be used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.

    摘要翻译： 本发明是用于治疗静脉曲张200或较大隐静脉202的改进方法和装置。该方法包括以1.2至2.2μm的范围使用红外激光辐射，从容器200或202内部的方式使得 血管壁704的内皮细胞被破坏，血管壁704中的胶原纤维被加热到它们永久收缩的位置，血管200或202被封闭并最终吸收。 该装置包括通过可以具有磨砂或漫射纤维尖端308的光纤导管300传送的激光器102，或者可以设置有保护隔离物的激光器102。 可以使用电动拉回装置104，并且可以使用热传感器600来帮助控制维持适当处理温度所需的功率。

    Attenuating beam splitter
    4.
    发明授权
    Attenuating beam splitter 失效
    衰减分束器

    公开(公告)号：US4711526A

    公开(公告)日：1987-12-08

    申请号：US882485

    申请日：1986-07-07

    申请人： David Hennings ,  Nubar Manoukian

    发明人： David Hennings ,  Nubar Manoukian

    IPC分类号： A61B18/20 ,  A61F9/008 ,  B23K26/06 ,  H01S3/00 ,  G02B27/12 ,  G02B27/14

    CPC分类号： H01S3/005 ,  A61F9/008 ,  A61F9/00821 ,  A61F9/00823 ,  B23K26/06 ,  B23K26/0604 ,  B23K26/064 ,  B23K26/0643 ,  B23K26/0652 ,  A61B2018/204

    摘要： An apparatus is disclosed for attenuating the beam of a laser. The apparatus is particularly suited for situations where a low powered aiming beam is necessary to be coaxially aligned with a full power working beam. The apparatus includes a refractive element having a pair of spaced-apart, parallel faces. A mounting arrangement is provided for selectively moving the refractive element into and out of the path of the full power laser beam. The refractive element is mounted such that when it is moved into the path of the laser beam, the beam will be split into primary and secondary beams. The primary beam will exit the refractive element along a path displaced from the incoming beam. The power of this exiting primary beam can be captured through a beam dump. The secondary beam is a product of at least two internal reflections within the refractive element. The secondary beam is highly attenuated and travels along the same path as the incoming beam. The secondary beam may be used for aiming since the full power beam will travel along the same path as the attenuated beam after the refractive element is moved out of its path.

    摘要翻译： 公开了用于衰减激光束的装置。 该装置特别适用于低功率瞄准光束与全功率工作光束同轴对准的情况。 该装置包括具有一对间隔开的平行面的折射元件。 提供了用于选择性地将折射元件移入和移出全功率激光束的路径的安装布置。 折射元件被安装成使得当其移动到激光束的路径中时，光束将被分裂成主光束和次光束。 主光束将沿着从入射光束移位的路径离开折射元件。 这个退出的主光束的能量可以通过光束转储来捕获。 次级光束是折射元件内的至少两个内部反射的乘积。 次级光束被高度衰减并沿与入射光束相同的路径传播。 次光束可以用于瞄准，因为在折射元件移出其路径之后，全功率光束将沿着与衰减光束相同的路径行进。

    CAPREOMYCIN DERIVATIVES AND THEIR USE AS ANTIBACTERIALS
    8.
    发明申请
    CAPREOMYCIN DERIVATIVES AND THEIR USE AS ANTIBACTERIALS 审中-公开
    CAPIROMYCIN衍生物及其作为抗生素的使用

    公开(公告)号：US20090203585A1

    公开(公告)日：2009-08-13

    申请号：US12299258

    申请日：2007-03-13

    申请人： Joseph P. Lyssikatos ,  Steven Mark Wenglowsky ,  D. David Hennings ,  Daniel John Watson

    发明人： Joseph P. Lyssikatos ,  Steven Mark Wenglowsky ,  D. David Hennings ,  Daniel John Watson

    IPC分类号： A61K38/12 ,  C07K7/06 ,  C07K1/06 ,  C12P21/04 ,  A61P31/04

    CPC分类号： C07K7/56 ,  A61K38/00 ,  Y02A50/401

    摘要： The present invention relates to phenylurea derivatives of capreomycin I, IIB, IIA, or IB, and metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial infections by administering such compounds. The present invention also relates to methods of preparing such compounds.

    摘要翻译： 本发明涉及卷曲霉素I，IIB，IIA或IB的苯基脲衍生物及其代谢产物及其药学上可接受的盐和溶剂化物。 本发明的化合物可用作治疗细菌感染和治疗由细菌感染引起的疾病的抗菌剂。 本发明还涉及含有这些化合物的药物组合物和通过施用这些化合物治疗细菌感染的方法。 本发明还涉及制备这些化合物的方法。

    ENDOVENOUS LASER TREATMENT GENERATING REDUCED BLOOD COAGULATION
    9.
    发明申请
    ENDOVENOUS LASER TREATMENT GENERATING REDUCED BLOOD COAGULATION 审中-公开
    内部激光治疗产生减少血液凝血

    公开(公告)号：US20080021527A1

    公开(公告)日：2008-01-24

    申请号：US11612324

    申请日：2006-12-18

    申请人： David Hennings ,  David Fullmer ,  Craig Lindsay

    发明人： David Hennings ,  David Fullmer ,  Craig Lindsay

    IPC分类号： A61N5/067

    CPC分类号： A61B18/24 ,  A61B2018/0097

    摘要： This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 2.2 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivering laser energy via a fiber optic catheter 300. A motorized pull back device 104 may be used. The laser is preferably operated under laser energy delivery conditions that substantially prevent the formation of coagulum on the energy emitting tip of the fiber.

    摘要翻译： 本发明是用于治疗静脉曲张200或较大隐静脉202的改进方法和装置。 该方法包括以从血管200或202内部的方式使用1.2至2.2μm区域的红外激光辐射，使得血管壁704的内皮细胞被损坏，血管壁704中的胶原纤维被加热到 它们永久收缩的点，容器200或202被封闭并最终吸收。 该装置包括经由光纤导管300输送激光能量的激光器102。 可以使用电动拉回装置104。 激光器优选在基本上防止在纤维的能量发射尖端上形成凝结物的激光能量传递条件下操作。

    TREATMENT OF CELLULITE AND ADIPOSE TISSUE WITH MID-INFRARED RADIATION
    10.
    发明申请
    TREATMENT OF CELLULITE AND ADIPOSE TISSUE WITH MID-INFRARED RADIATION 有权
    用中红外辐射处理细胞和纤维组织

    公开(公告)号：US20070293849A1

    公开(公告)日：2007-12-20

    申请号：US11847153

    申请日：2007-08-29

    申请人： David Hennings ,  David Fullmer

    发明人： David Hennings ,  David Fullmer

    IPC分类号： A61B18/22

    CPC分类号： A61B18/203 ,  A61B18/22 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/2005 ,  A61N2005/0659

    摘要： A method and apparatus that will alter the fibrous strands in the fatty layers of the skin to reduce the appearance of cellulite and adipose tissue. Electromagnetic energy is used to selectively shrink or alternatively photoacoustically ablate the collagen in the constricting bands of connective tissue that causes the dimpled appearance of cellulite and adipose tissue while avoiding damage to the surrounding fatty cells.

    摘要翻译： 将改变皮肤脂肪层中的纤维束以减少脂肪团和脂肪组织的外观的方法和装置。 电磁能用于选择收缩或者替代地光声消融结缔组织的收缩带中的胶原，导致脂肪团和脂肪组织的凹凸出现，同时避免对周围脂肪细胞的损伤。