公开(公告)号：US08649647B2

公开(公告)日：2014-02-11

申请号：US13338624

申请日：2011-12-28

Applicant: Gary McBroom ,  David McDaniel ,  Chang Kim

Inventor： Gary McBroom ,  David McDaniel ,  Chang Kim

IPC: G02B6/10

CPC classification number: G01T1/1644

Abstract: A method of manufacturing a light guide assembly includes the steps of providing a light guide array made of a light-transmissive material and having a top portion and an integral bottom portion supporting the top portion, wherein grooves are formed on a top surface of the top, providing an optical isolation frame of interconnected slats made of an opaque material wherein the slats are arranged and profiled to correspondingly match the grooves in the light guide array, bonding the light guide array and the optical isolation frame to each other, and removing the bottom portion of the light guide array.

Abstract translation: 一种制造导光组件的方法包括以下步骤：提供由透光材料制成的导光阵列，并具有支撑顶部的顶部和整体底部，其中在顶部的顶表面上形成有凹槽 ，提供由不透明材料制成的互连板条的光学隔离框架，其中板条被布置和成型以相应地匹配光导阵列中的凹槽，将光导阵列和光隔离框架彼此粘合，并且移除底部 光导阵列的一部分。

公开(公告)号：US20130214168A1

公开(公告)日：2013-08-22

申请号：US13400243

申请日：2012-02-20

Applicant: David McDaniel ,  Changlyong Kim ,  Mark David Fries

Inventor： David McDaniel ,  Changlyong Kim ,  Mark David Fries

IPC: G01T1/164

CPC classification number: G01T1/2985

Abstract: A method of correcting a timing signal that represents an arrival time of a photon at a positron emission tomography (PET) detector includes receiving a timing signal that represents an arrival time of a photon at a PET detector, receiving an energy signal indicative of an energy of the photon, calculating a timing correction using the energy signal, modifying the timing signal using the timing correction, and generating an image of an object using the modified timing signal. A system and non-transitory computer readable medium are also described herein.

Abstract translation: 校正表示正电子发射断层摄影（PET）检测器上的光子到达时间的定时信号的方法包括：接收表示PET检测器处的​​光子到达时间的定时信号，接收指示能量的能量信号 使用所述能量信号计算定时校正，使用所述定时校正修改所述定时信号，以及使用所述修改的定时信号生成对象的图像。 本文还描述了系统和非暂时性计算机可读介质。

公开(公告)号：US20130170792A1

公开(公告)日：2013-07-04

申请号：US13338704

申请日：2011-12-28

Applicant: Chang Kim ,  David McDaniel ,  Gary McBroom

Inventor： Chang Kim ,  David McDaniel ,  Gary McBroom

IPC: G02B6/26 ,  B29C65/08 ,  B29C45/14

CPC classification number: G01T1/2018 ,  Y10T156/1089

Abstract: A method of fabricating a light guide assembly includes the steps of providing an array of generally frustum-shaped light guides made of a light-transmissive material, providing an optical isolation frame of interconnected slats made of an opaque material, wherein the slats are arranged and profiled to correspondingly match the gaps between the light guides and the outer gap around the periphery of the light guide array, and bonding the light guide array and the optical isolation frame to each other.

Abstract translation: 一种制造光导组件的方法包括以下步骤：提供由光透射材料制成的大致截头锥形光导阵列，提供由不透明材料制成的互连板条的光学隔离框架，其中板条被布置，并且 成形为相应地匹配导光体周围的光导与外部间隙之间的间隙，并将光导阵列和光隔离框架彼此接合。

公开(公告)号：US20110210255A1

公开(公告)日：2011-09-01

申请号：US12714529

申请日：2010-02-28

Applicant: Chang Lyong Kim ,  David McDaniel ,  Floribertus P.M. Heukensfeldt Jansen

Inventor： Chang Lyong Kim ,  David McDaniel ,  Floribertus P.M. Heukensfeldt Jansen

IPC: G01T1/20

CPC classification number: G01T1/2985 ,  A61B6/037

Abstract: A method for producing a PET image of a tissue using a PET scanner, the scanner comprising a plurality of scintillation crystals (70X/75X) and a plurality of detectors (71X/76X). The method comprises forming a first crystal group (160X) including a first subset of the plurality of crystals; forming a second crystal group (164X) including a second subset of the plurality of crystals, wherein crystals comprising the first crystal group (160X) are different from crystals comprising the second crystal group (164X); converting a first beam (120) striking one or more crystals of the first crystal group (70X/160X) to a first electrical signal (94); converting a second beam striking one or more crystals of the second crystal group (75X/164X) to a second electrical signal (98), wherein the second beam is scattered from the first beam; determining one or both of a first and a second timing relationship, wherein the first timing relationship (Δt2) is a time interval between a value of the first electrical signal (94) and a time reference (t1), and the second timing relationship (Δt3) is a time interval between a value of the second electrical signal (98) and the time reference (t1); correcting the second electrical signal (98) to produce a corrected second electrical signal using a correction factor derived from at least one of the first and the second timing relationships to compensate for energy in the second signal scattered from the first signal; and creating an image of the tissue (12) using the corrected second electrical signal.

Abstract translation: 一种使用PET扫描仪生产组织的PET图像的方法，所述扫描器包括多个闪烁晶体（70X / 75X）和多个检测器（71X / 76X）。 该方法包括形成包括多个晶体的第一子集的第一晶体组（160X） 形成包含多个晶体的第二子集的第二晶体组（164X），其中包含第一晶体组（160X）的晶体与包含第二晶体组（164X）的晶体不同; 将第一晶体组（70X / 160X）的一个或多个晶体的第一光束（120）转换成第一电信号（94）; 将第二晶体组（75X / 164X）的一个或多个晶体的第二光束转换成第二电信号（98），其中所述第二光束从所述第一光束散射; 确定第一和第二定时关系中的一个或两个，其中所述第一定时关系（＆Dgr; t2）是所述第一电信号（94）的值与时间基准（t1）之间的时间间隔和所述第二定时 关系（＆Dgr; t3）是第二电信号（98）的值与时间基准（t1）之间的时间间隔; 使用从第一和第二定时关系中的至少一个导出的校正因子校正第二电信号（98）以产生校正的第二电信号，以补偿从第一信号散射的第二信号中的能量; 以及使用校正的第二电信号创建组织（12）的图像。

公开(公告)号：US20100256550A1

公开(公告)日：2010-10-07

申请号：US12753207

申请日：2010-04-02

Applicant: David McDaniel

Inventor： David McDaniel

IPC: A61M37/00

CPC classification number: A61N5/0617 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61N5/062 ,  A61N2005/0652

Abstract: A system for producing preferential damage to hair exiting mammalian skin. A agent having an average diameter for enabling the agent to penetrate the hair duct is selected. The agent is designed to attach to, or become physically incorporated into, the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent has an electromagnetic radiation absorption characteristic which enables the agent to absorb a first wavelength of electromagnetic radiation from a skin-penetrating electromagnetic radiation source, such as a laser. The agent is applied to the skin so that the agent penetrates the skin and attaches to or becomes physically incorporated into the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent is exposed to the first wavelength of electromagnetic radiation and absorbs the first wavelength of electromagnetic radiation.

Abstract translation: 用于对离开哺乳动物皮肤的毛发产生优先损伤的系统。 选择具有使试剂穿过发道的平均直径的试剂。 该药剂被设计成附着到头发，头发毛囊，毛发或头发管道上，或者将它们物理地并入到头发，毛发，头发灯泡或发道中。 该试剂具有电磁辐射吸收特性，其使得试剂能够从诸如激光的皮肤穿透电磁辐射源吸收第一波长的电磁辐射。 将药剂施用于皮肤，使得药剂渗透皮肤并附着或变成物理地并入毛发，毛囊，毛发或毛发管道中。 该试剂暴露于第一波长的电磁辐射并吸收第一波长的电磁辐射。

公开(公告)号：US20080249595A1

公开(公告)日：2008-10-09

申请号：US11696257

申请日：2007-04-04

Applicant: Benjamin David McDaniel

Inventor： Benjamin David McDaniel

IPC: A61N1/05

CPC classification number: A61B18/1492 ,  A61B2018/00148 ,  A61B2018/00702 ,  A61B2018/00791

Abstract: An EP catheter includes a tip electrode having a core primarily comprised of copper with an outer layer of a biocompatible metal disposed thereon exhibits appropriate electrical and thermal conduction characteristics while being cost-effective to produce. Alternatively, an inner layer of a biocompatible metal is disposed on the inside of the primarily copper core. Such a tip electrode may also be provided with irrigation lumens. Such a tip electrode could be manufactured from sheets of metal that upon extrusion would comprise the outer layer, core and optional inner layer respectively.

Abstract translation: EP导管包括尖端电极，其具有主要由铜组成的芯，其上布置有生物相容性金属的外层，其具有适当的电和热传导特性，同时具有生产成本效益。 或者，生物相容性金属的内层设置在主要铜芯的内侧。 这样的尖端电极也可以设置有冲洗腔。 这种尖端电极可以由金属片制成，其在挤出时将分别包括外层，芯和任选的内层。

公开(公告)号：US20060200213A1

公开(公告)日：2006-09-07

申请号：US11332517

申请日：2006-01-17

Applicant: David McDaniel

Inventor： David McDaniel

IPC: A61N5/06

CPC classification number: A61N5/0616 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61K41/0057 ,  A61K41/0071 ,  A61N5/0617 ,  A61N5/062 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/067

Abstract: Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.

公开(公告)号：US20060184214A1

公开(公告)日：2006-08-17

申请号：US11346622

申请日：2006-02-03

Applicant: David McDaniel

Inventor： David McDaniel

IPC: A61N5/06

CPC classification number: A61N5/0616 ,  A61N5/0601 ,  A61N5/0613 ,  A61N2005/0605 ,  A61N2005/0609 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0654 ,  A61N2005/0662 ,  A61N2005/067

Abstract: Disclosed is a system and method for treatment of cells and, in particular, visual pathway disorders. More particularly, the disclosed invention is directed toward the photomodulation and/or photorejuvenation of retinal epithelial cells, to treat a variety of vision disorders. The process of treating retinal cells to reduce or reverse the effects of visual pathway disorders employs a narrowband source of multichromatic light applied to the retinal cells to deliver a very low energy fluence.

公开(公告)号：US20060129209A1

公开(公告)日：2006-06-15

申请号：US11212916

申请日：2005-08-29

Applicant: David McDaniel

Inventor： David McDaniel

IPC: A61N5/06

CPC classification number: A61K8/02 ,  A61B18/203 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61K41/0004 ,  A61K2800/81 ,  A61N5/0617 ,  A61N5/062 ,  A61N2005/0652 ,  A61Q7/00

Abstract: A system for producing hair growth stimulation using light energy, topical compositions, and combinations thereof. By using photomodulation resulting from cellular responses to exposure to specific wavelengths of light, optionally in conjunction with topical compositions and procedures for enhancing the penetration of such compositions, hair follicles are activated to produce hair growth.

公开(公告)号：US20050156112A1

公开(公告)日：2005-07-21

申请号：US11028270

申请日：2005-01-03

Applicant: John Williams ,  Dershan Luo ,  Mark Limkeman ,  Michael Cook ,  David McDaniel ,  Edwin Oswalt ,  Mark Feilen

Inventor： John Williams ,  Dershan Luo ,  Mark Limkeman ,  Michael Cook ,  David McDaniel ,  Edwin Oswalt ,  Mark Feilen

IPC: G01T1/161 ,  G01T1/164 ,  G01T1/172 ,  G01T1/29

CPC classification number: G01T1/2985

Abstract: A method of calibrating detectors in a detector ring of a PET scanner, each detector including a plurality of crystals, the PET scanner having a field of view, is disclosed. The method comprises collecting timing data indicative of coincidence events occurring between each pair of crystals within the field of view. The method further comprises determining a detector adjustment value for each detector, determining a crystal adjustment value for each crystal in each detector, and discretizing the crystal adjustment value for each crystal to produce a discretized crystal adjustment value for each crystal. Lastly, the method comprises calibrating each detector by applying the discretized crystal adjustment value for each crystal in each detector to the collected timing data indicative of coincidence events.

Abstract translation: 公开了一种校准PET扫描器的检测器环中的检测器的方法，每个检测器包括多个晶体，PET扫描器具有视野。 该方法包括收集指示在视场内的每对晶体之间发生的重合事件的定时数据。 该方法还包括确定每个检测器的检测器调整值，确定每个检测器中的每个晶体的晶体调整值，以及离散每个晶体的晶体调整值以产生每个晶体的离散晶体调节值。 最后，该方法包括通过将每个检测器中的每个晶体的离散晶体调整值应用于指示符合事件的收集的定时数据来校准每个检测器。