公开(公告)号：US20100095965A1

公开(公告)日：2010-04-22

申请号：US12589015

申请日：2009-10-16

Applicant: S. David Piper

Inventor： S. David Piper

IPC: A61M16/20

CPC classification number: A61M16/20 ,  A61M16/0816 ,  A61M16/208

Abstract: The present invention relates generally to devices and methods for finite control and regulation of patient intrathoracic pressures, and more specifically, to devices and methods that are finitely adjustable within a range set by an operator for regulating a patient intrathoracic pressures during repeated cycling events (i.e. respiration). The enhanced means includes a dual area valve on an exhalation and/or inhalation port of a device such that the valve is biased against the pressure necessary to evacuate and/or inflate the lungs of that patient by at least a partial volume thereof. The enhanced means for regulating intrathoracic pressure are applicable in a number of medically important therapies, including but not limited to, conditioning of pulmonary systems for acclimation to altered environmental conditions, reconditioning of pulmonary system after operating in a diminished state, and application in cardiopulmonary resuscitation procedures.

Abstract translation: 本发明一般涉及用于有限控制和调节患者胸内压力的装置和方法，更具体地涉及在由操作者设定的范围内有限可调节的装置和方法，用于在重复循环事件期间调节患者胸内压力（即 呼吸）。 增强的装置包括在装置的呼气和/或吸入端口上的双重区域阀，使得阀被抵抗使该患者的肺排出和/或膨胀其至少部分体积所需的压力。 用于调节胸内压力的增强手段适用于许多医学上重要的疗法，包括但不限于调节适应改变的环境条件的肺系统，在减少的状态下操作后肺系统的修复，以及在心肺复苏中的应用 程序。

公开(公告)号：US08133695B2

公开(公告)日：2012-03-13

申请号：US12394605

申请日：2009-02-27

Applicant: David Piper ,  Kurt Vogel ,  Mohammed Saleh Shekhani ,  Stephen Hess ,  Steve Duff ,  Thomas Livelli ,  Zhong Zhong

Inventor： David Piper ,  Kurt Vogel ,  Mohammed Saleh Shekhani ,  Stephen Hess ,  Steve Duff ,  Thomas Livelli ,  Zhong Zhong

IPC: G01N33/53 ,  G01N33/532 ,  G01N33/533

CPC classification number: G01N33/582 ,  C07D491/107 ,  G01N33/6872 ,  Y10T436/13

Abstract: Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.

Abstract translation: 公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。 特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。 本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

公开(公告)号：US06981660B2

公开(公告)日：2006-01-03

申请号：US10462007

申请日：2003-06-13

Applicant: Samuel David Piper

Inventor： Samuel David Piper

IPC: B05R7/04 ,  B05R7/12 ,  B05R7/06 ,  A62C5/02

CPC classification number: B05B7/0433 ,  A61M11/001 ,  A61M11/06 ,  A61M15/0028 ,  A61M15/0045 ,  A61M2205/0233 ,  A61M2205/07 ,  A61M2205/12 ,  A61M2205/21 ,  A61M2205/8225

Abstract: A pneumatic inhaler that is able to deliver a controlled burst or dose of aerosol from a reservoir of liquid or powder medication. A supersonic jet of gas is emitted from a nozzle and shock waves are developed in the jet. In one embodiment the supersonic jet is directed into a shock chamber. Liquid or micronized powder material is introduced into the supersonic jet to form an aerosol. In one embodiment, smaller aerosol particles are separated from larger aerosol particles with a separator. In another embodiment, the produced aerosol is contained in an aerosol storage chamber prior to inhalation by the users.

Abstract translation: 一种气动吸入器，能够从液体或粉末药物储存器输送受控的爆发或剂量的气溶胶。 从喷嘴喷出超音速喷气，在射流中产生冲击波。 在一个实施例中，超音速射流被引导到冲击室中。 将液体或微粉化的粉末材料引入超音速射流中以形成气溶胶。 在一个实施方案中，较小的气溶胶颗粒与较大的气溶胶颗粒与分离器分离。 在另一个实施方案中，所产生的气溶胶在用户吸入之前被包含在气溶胶储存室中。

公开(公告)号：US06338443B1

公开(公告)日：2002-01-15

申请号：US09592119

申请日：2000-06-12

Applicant: Samuel David Piper

Inventor： Samuel David Piper

IPC: A61M1106

CPC classification number: A61M11/06 ,  A61M11/002

Abstract: A pneumatic nebulizer that produces a high volume of aerosols for inhalent delivery of medications and other constituencies. High pressure gas formed into a gas jet is passed through a thin choked region of fluid that is entrailed and impinged upon an aerosol amplifier which creates a spray whose aerosol components are directed up through vents to an aerosol outlet for delivery. Larger-sized liquid particles are caused to pool up in a region surrounding the aerosol amplifer and then drip down back into the liquid medication reservoir.

Abstract translation: 一种气动雾化器，产生大量的气溶胶，用于吸入药物和其他选区。 形成为气体射流的高压气体通过流体的薄扼流区域，其被夹带并撞击在气溶胶放大器上，该气溶胶放大器产生喷雾，其气雾成分通过通风口引导到气溶胶出口用于输送。 使较大尺寸的液体颗粒在气溶胶扩增器周围的区域中汇集，然后滴落回液体药物储存器。

公开(公告)号：US5760787A

公开(公告)日：1998-06-02

申请号：US516071

申请日：1995-08-17

Applicant: Anthony David Piper

Inventor： Anthony David Piper

IPC: G06T11/20 ,  G06T9/00 ,  G06F15/00

CPC classification number: G06T9/001

Abstract: A method and apparatus for storing data defining a graphical outline of an object, the graphical outline comprising a series of curve segments. First, those curve segments which comprise straight line segments are determined. The method next stores a first number of associated control points for each of said curve segments which do not comprise straight line segments. The method then operates to store a reduced number of associated control points for each of the curve segments which comprise straight line segments.

Abstract translation: 一种用于存储定义对象的图形轮廓的数据的方法和装置，所述图形轮廓包括一系列曲线段。 首先，确定包括直线段的那些曲线段。 该方法接下来存储不包括直线段的每个所述曲线段的第一数量的相关控制点。 该方法然后操作以存储包括直线段的每个曲线段的减少数量的相关控制点。

公开(公告)号：US08596263B2

公开(公告)日：2013-12-03

申请号：US12927332

申请日：2010-11-12

Applicant: Samuel David Piper

Inventor： Samuel David Piper

IPC: B05B1/26 ,  A61M11/00

CPC classification number: A61M11/06 ,  A61M11/002 ,  A61M15/0021 ,  A61M15/008 ,  A61M15/0091 ,  A61M15/0093 ,  A61M15/0098 ,  A61M16/0833 ,  A61M16/1065 ,  A61M16/20 ,  A61M16/206 ,  A61M16/208 ,  B05B7/0433

Abstract: The present invention is directed generally to a nebulizer for the formation of micro-droplets from liquid medicaments for respiratory patient treatment, and more specifically, to a baffled nebulizer wherein a static baffle used to form an atomized medicament is proximal to a shied which responds to patient respiration force to oscillate from an aerosol flow occluding position to an aerosol flow open position. During inhalation, the shield moves into a first registration format to allow passage of the atomized medicament (nebula) to the patient. During exhalation/non-use, a biasing pressure maintains said shield in a second registration format such that the nebula is retarded from passing to the patient and is coalesced into macro-droplets which return to a supply reservoir for re-atomization. The present nebulizer design is particularly adaptable for controlling atomization in response to patient respiratory forces exceeding a defined threshold; allowing for opportunity to control inhalation airflow and enhanced therapy regimes.

Abstract translation: 本发明一般涉及一种用于从用于呼吸患者治疗的液体药物形成微滴的喷雾器，更具体地说，涉及一种用于形成雾化药剂的静态挡板近似于一个响应于 患者呼吸力从气雾剂阻塞位置振荡到气溶胶流动打开位置。 在吸入期间，护罩移动到第一注册格式以允许雾化的药物（星云）通过患者。 在呼气/不使用期间，偏压压力使所述护罩以第二配准格式保持，使得星云延迟不能传递到患者身上，并且被聚结成返回到用于再雾化的供应储器的大液滴。 目前的喷雾器设计特别适用于响应于患者呼吸力超过规定的阈值来控制雾化; 允许机会控制吸入气流和增强的治疗方案。

公开(公告)号：US20090253148A1

公开(公告)日：2009-10-08

申请号：US12394605

申请日：2009-02-27

Applicant: David Piper ,  Stephen Hess ,  Mohammed Saleh Shekhani ,  Thomas Livelli ,  Zhong Zhong ,  Steve Duff ,  Kurt Vogel

Inventor： David Piper ,  Stephen Hess ,  Mohammed Saleh Shekhani ,  Thomas Livelli ,  Zhong Zhong ,  Steve Duff ,  Kurt Vogel

IPC: G01N33/53 ,  G01N33/566 ,  C12N5/06 ,  C12N5/08 ,  C07D491/10

CPC classification number: G01N33/582 ,  C07D491/107 ,  G01N33/6872 ,  Y10T436/13

Abstract: Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.

Abstract translation: 公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。 特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。 本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

公开(公告)号：US06664229B2

公开(公告)日：2003-12-16

申请号：US09211823

申请日：1998-12-15

Applicant: James Joseph Hagan ,  Jonathan Alexander Terrett ,  Neil Upton ,  David Piper ,  Martin Ian Smith ,  Guy Anthony Kennett ,  Saraswati R. Patel

Inventor： James Joseph Hagan ,  Jonathan Alexander Terrett ,  Neil Upton ,  David Piper ,  Martin Ian Smith ,  Guy Anthony Kennett ,  Saraswati R. Patel

IPC: A61K3817

CPC classification number: C07K16/28 ,  A61K38/22

Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose or treat diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

Abstract translation: 提供HFGAN72受体配体的多肽和编码多肽的多核苷酸。 还提供了使用这些多肽诊断或治疗与HFGAN72受体配体的低表达或过度表达有关的疾病的方法。 另外，提供了识别HFGAN72受体配体与HFGAN72受体相互作用的激动剂或拮抗剂的方法。 还公开了通过将所鉴定的激动剂或拮抗剂给予需要的患者的治疗方法。

公开(公告)号：US06390090B1

公开(公告)日：2002-05-21

申请号：US09429243

申请日：1999-10-28

Applicant: Samuel David Piper

Inventor： Samuel David Piper

IPC: A61M1600

CPC classification number: A61M15/0086 ,  A61M11/06 ,  A61M15/0088

Abstract: An inhalation therapy device includes a collapsible aerosol storage bag (7) having an opening which connects to the end of a dual port member, one port (8) of which is in fluid communication with a nebulizer. During patient exhalation the aerosol storage bag becomes partially inflated with exhaled gas during the first part of exhalation. The laminar coherent aerosol jet exits the dual port member and remains coherent until reaching the end of the aerosol storage bag, at which time it diverges and expels all exhaled gas from the aerosol storage bag, thus filling the aerosol storage bag with aerosol. All escaping gas exits the aerosol storage bag via the remaining port (9) of the dual port member, where it escapes into the ambient environment through the ambient port. The remaining dual port of the dual port member, in addition to providing means for escaping gas from the aerosol storage bag, is also in fluid communication with the ambient port and the mouthpiece (1). Upon inhalation, the patient inhales the aerosol within the aerosol storage bag, the aerosol produced by the nebulizer during inhalation, and ambient air through the ambient port. The cycle is than repeated indefinitely.

Abstract translation: 吸入治疗装置包括可折叠气溶胶储存袋（7），其具有连接到双端口构件的端部的开口，其一个端口（8）与雾化器流体连通。 在患者呼气期间，在呼气的第一部分期间，气雾剂储存袋在呼出气体中部分膨胀。 层状相干气溶胶喷射器离开双端口构件并保持连贯，直到到达气溶胶储存袋的端部，此时它从气溶胶储存袋分散并排出所有呼出气体，从而用气溶胶填充气溶胶储存袋。 所有逸出的气体都通过双端口构件的剩余端口（9）离开气溶胶储存袋，通过环境端口逃逸到周围环境中。 除了提供用于从气溶胶存储袋中排出气体的装置之外，双端口构件的剩余双端口还与环境端口和接口（1）流体连通。 吸入后，患者吸入气雾剂储存袋内的气溶胶，吸入期间由喷雾器产生的气溶胶，以及通过环境口的环境空气。 这个循环是无限期重复的。

公开(公告)号：US20110120473A1

公开(公告)日：2011-05-26

申请号：US12927755

申请日：2010-11-22

Applicant: Samuel David Piper

Inventor： Samuel David Piper

IPC: A61M16/20

CPC classification number: A61M16/208

Abstract: The present invention relates generally to devices and methods for finite control and regulation of patient intrathoracic pressures, and more specifically, to devices and methods that finitely regulates a patient's intrathoracic pressures during repeated cycling events (i.e. respiration) by use of a cross-seal vent valve to form transient pressure windows. The cross-seal vent valve is biased against the pressure necessary to evacuate and/or inflate the lungs of that patient, while a controlled venting of that pressure by at least a partial volume thereof allows for controlled resetting of the baseline pressure to anatomical norms. This enhanced means for regulating intrathoracic pressure are applicable in a number of medically important therapies, including but not limited to, conditioning of pulmonary systems for acclimation to altered environmental conditions, reconditioning of pulmonary system after operating in a diminished state, and application in cardiopulmonary resuscitation procedures.

Abstract translation: 本发明一般涉及用于有限控制和调节患者胸内压力的装置和方法，更具体地，涉及通过使用十字密封通气口在反复循环事件（即，呼吸）期间有限地调节患者的胸内压力的装置和方法 阀门形成瞬时压力窗口。 交叉密封排气阀被压靠在抽空和/或充气该患者的肺所需的压力上，同时将该压力的受控排放至少部分体积允许基线压力被控制地重新设定为解剖规范。 这种用于调节胸腔内压力的增强方法适用于许多医学上重要的疗法，包括但不限于调节适应改变的环境条件的肺系统，在减少的状态下操作后对肺系统的修复，以及在心肺复苏中的应用 程序。