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    METHOD OF TREATING SCHIZOPHRENIA AND/OR GLUCOREGULATORY ABNORMALITIES
    7.
    发明申请
    METHOD OF TREATING SCHIZOPHRENIA AND/OR GLUCOREGULATORY ABNORMALITIES 审中-公开

    公开(公告)号：US20070129403A1

    公开(公告)日：2007-06-07

    申请号：US11536808

    申请日：2006-09-29

    申请人： Craig Smith ,  David Rampe ,  Beth Borowsky ,  Sathapana Kongsamut

    发明人： Craig Smith ,  David Rampe ,  Beth Borowsky ,  Sathapana Kongsamut

    IPC分类号： A61K31/4439

    CPC分类号： A61K31/4439

    摘要： The present invention provides methods of treating schizophrenia and/or glucoregulatory abnormalities in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a compound of formula I wherein in is 0, 1 or 2; n is 0, 1 or 2; p is 0 or 1; each R is independently hydrogen, halogen, trifluoromethyl, C1-C6alkyl, C1-C6alkoxy, benzyloxy, hydroxy, nitro or amino; each R1 is independently hydrogen, C1-C6alkyl, C1-C6alkenyl, C1-C6alkanoyl, halogen, cyano, —C(O)C1-C6alkyl, —C1-C6alkyleneCN, —C1-C6alkyleneNR′R″ wherein R′ and R″ are each independently hydrogen or C1-C6alkyl, —C1-C6alkyleneOC(O)C1-C6alkyl, or —CH(OH)R4 wherein R4 is hydrogen or C1-C6alkyl; R2 is hydrogen, C1-C6alkyl optionally substituted with halogen, hydroxy or benlzyloxy, C1-C6alkenyl, C1-C6alkynyl, —CO2C1-C6alkyl, or —R5—NR′R″ wherein R5 is C1-C6alkylene, C1-C6alkenylene or C1-C6alkynylene and R′ and R″ are each independently hydrogen, C1-C6alkyl or alternatively the group —NR′R″ as a whole is 1-pyrrolidinyl; and R3 is hydrogen, nitro, amino, halogen, C1-C6alkoxy, hydroxy or C1-C6alkyl or a pharmaceutically acceptable salt thereof.

    Method of treating demyelinating diseases or conditions
    8.
    发明授权
    Method of treating demyelinating diseases or conditions 有权
    治疗脱髓鞘疾病或病症的方法

    公开(公告)号：US07534803B2

    公开(公告)日：2009-05-19

    申请号：US11236145

    申请日：2005-09-27

    申请人： Craig P. Smith ,  Michel P. Rathbone ,  Margaret Petty ,  David Rampe

    发明人： Craig P. Smith ,  Michel P. Rathbone ,  Margaret Petty ,  David Rampe

    IPC分类号： A61K31/44

    CPC分类号： A61K31/4439 ,  Y10S514/903

    摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

    摘要翻译： 式I的N-（吡啶基）-1H-吲哚-1-胺提供钾和钠通道的阻断性质的独特组合。 这些化合物可用于治疗脱髓鞘疾病和病症如多发性硬化，脊髓损伤，创伤性脑损伤和中风。 这些化合物也可用于中风康复，膀胱刺激和功能障碍的治疗，以及治疗神经性疼痛和趋化因子诱导的疼痛。